Molecular Pathology in Drug Discovery and Development (eBook)

J. Suso Platero (Herausgeber)

eBook Download: PDF

2009 | 1. Auflage
376 Seiten
John Wiley & Sons (Verlag)
978-0-470-47594-2 (ISBN)

Infos

Covers powerful new tools for drug development

Molecular pathology offers tools and techniques that can greatly
enhance the drug discovery and development process, helping to make
the promises of personalized medicine a reality. Molecular
Pathology in Drug Discovery and Development provides an unmatched
guide to this cutting-edge discipline and its applications to
pharmaceutical science.

With contributions from leading lights in drug discovery, drug
development, and molecular pathology balanced by a consistent
editorial approach, this reference offers both an overview of
molecular pathology and a close look at the methods as they are
applied to the process of drug discovery and development. Presented
as steps in the drug development process, the coverage includes the
use of molecular pathology to:

* Identify and validate new drug candidates

* Enhance transcriptional profiling to better find and validate
biomarkers

* Assess toxicology

* Employ toxicogenomics to identify genes relevant to the safety
of compounds

* Identify correct doses for different drugs

* Identify patients for treatment

* Develop molecular therapies

* Further the new techniques of Immunohistochemistry and
Immunofluorescence

With many tests and treatments already working today, drug
research and development using molecular pathology has shown itself
an extremely fruitful area. Molecular Pathology in Drug Discovery
and Development gives practitioners an up-to-date resource on this
highly active discipline and its role in furthering pharmaceutical
research.

Autor

J. Suso Platero is Director of Oncology Biomarkers at Centocor. Formerly, he was associate director of molecular pathology at Bristol-Myers Squibb. Dr. Platero has more than ten years of experience in the discovery, development, and validation of assays for clinical purposes.

Inhalt

1. Introduction to Molecular Pathology and Drug Development (Franz Fogt, University of Pennsylvania and J. Suso Platero).

2. Molecular Pathology in early drug discovery (Matt Lorenzi, Rolf Ryseck, Brent Rupnow and Ricardo Attar).

3. Molecular Pathology and transcriptional profiling in early drug development (Cornelia Liedtke, Lajos Pusztai and W. Fraser Symmans).

4. Nonclinical Safety Assessment (Richard A. Westhouse).

5. Toxicogenomics in Drug Development (Wayne Buck and Eric A. G. Blomme).

6. Molecular Pathology as a way to find the right dose for the drug (F. Rojo, A. Rovira, S. Serrano and J. Albanell).

7. Molecular Pathology in Life Cycle Management in Drug Development (David Berman).

8. Molecular Pathology and Molecular Therapy (Hewei Li).

9. Contract Research Organizations and Molecular Pathology in drug development (Frank Lynch and Steve Bernstein).

10. Moving to a Quantification of Molecular Pathology: Colorimetric Immunohistochemistry (Raphael Marcelpoil).

11. AQUA Technology and Molecular Pathology (Mark Gustavson, Marisa Dolled-Filhart, Jason Christiansen, Robert Pinard1).

Rezensionen

"Molecular Pathology in Drug Discovery and Development is a well-written book that provides both an overview of how biomarkers may be developed and detailed explanations of how to measure and analyze said biomarkers." (The Yale Journal of Biology and Medicine, March 2010)

Produkt-Details

• Erscheint lt. Verlag: 7.8.2009
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Gesundheitsfachberufe
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
• Themenwelt: Studium ► 2. Studienabschnitt (Klinik) ► Pathologie
• Themenwelt: Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
• Themenwelt: Naturwissenschaften ► Chemie
• Schlagworte: Arzneimittelforschung • Biowissenschaften • Cell & Molecular Biology • Chemie • Chemistry • Drug Discovery & Development • Life Sciences • Medical Science • Medizin • Molekularpathologie • Pharmacology & Pharmaceutical Medicine • Pharmakologie u. Pharmazeutische Medizin • Wirkstoffforschung u. -entwicklung • Zell- u. Molekularbiologie
• ISBN-10: 0-470-47594-3 / 0470475943
• ISBN-13: 978-0-470-47594-2 / 9780470475942