Antiviral Drug Discovery for Emerging Diseases and Bioterrorism Threats (eBook)

Paul F. Torrence (Herausgeber)

eBook Download: PDF

2005 | 1. Auflage
400 Seiten
John Wiley & Sons (Verlag)
978-0-471-71670-9 (ISBN)

Infos

Antiviral Drug Discovery gives readers a cutting-edge view of how chemical concepts are being mobilized to develop novel approaches that will effectively confront emerging diseases and biowarfare. Among the many topics discussed are smallpox, the Ebola virus, influenza, SARS, arenaviruses and flaviviruses. Each chapter discusses hypothetical strategies for the discovery of relevant antiviral agents, recent findings related to biochemistry or drug discovery, and advances in the further development of established leads in the area. Timely and informative, this book clearly delineates the efforts being made to develop new and effective broad-spectrum antiviral agents.

Autor

PAUL F. TORRENCE, PhD, is Professor of Chemistry at Northern Arizona University. He is the editor of Biomedical Chemistry: Applying Chemical Principles to the Understanding and Treatment of Disease and serves on the editorial boards for the journals Antiviral Research and Current Medicinal Chemistry.

Inhalt

Preface.

Contributors.

1. Introduction: Pestilence, Plague, Bioterrorism (Paul F.
Torrence).

2. Viral Bioterrorism and Antiviral Countermeasures (Mike
Bray).

3. Overview of Antiviral Drug Discovery and Development
(Christopher K. Tseng).

4. Antiviral Drug Targets and Strategies for Emerging Viral
Diseases and Bioterrorism Threats (Erik De Clercq).

5. Perspectives for the Therapy Against Arenavirus Infections
(Elsa B. Damonte and Cybele C. García).

6. S-Adenosylhomocysteine Hydrolase Inhibitors as a Source of
Anti-Filovirus Agents (Stewart W. Schneller and Minmin Yang).

7. Antiviral Strategies for Ebola Virus (Jillian M. Licata and
Ronald N. Harty).

8. IMPDH Inhibitors: Discovery of Antiviral Agents Against
Emerging Diseases (Vasu Nair).

9. Lethal Mutagenesis: Exploiting Error-Prone Replication of
Riboviruses for Antiviral Therapy (Jason D. Graci and Craig E.
Cameron).

10. Structural Biology of Flaviviral Replication and
Opportunities for Drug Design (Krishna Murthy).

11. Confronting New and Old Antiviral Threats: Broad Spectrum
Potential of Prenylation Inhibitors (Menashe Elazar and Jeffrey S.
Glenn).

12. West Nile Virus: New Targets for Potential Antivirals
(Matthias Kalitzky, Holger Rohde, and Peter Borowski).

13. The Emergence of Pandemic Influenza A: Bioterrorist Versus
Mother Nature (John S. Oxford, Alison Boyers, Alex Mann, and R.
Lambkin).

14. Discovery and Development of New Antivirals for Smallpox
(Earl R. Kern).

15. Viral Countermeasures to the Host Interferon Response: Role
of the Vaccinia Virus E3L and K3L Genes (Jeffrey O. Langland,
Vanessa Lancaster, and Bertram L. Jacobs).

16. Broad-Spectrum Antiviral Prophylaxis: Inhibition of Viral
Infection by Polymer Grafting with Methoxypoly(ethylene glycol)
(Lori L. McCoy and Mark D. Scott).

17. Viral Evasion of the Interferon System: Novel Targets for
Drug Discovery (Paul F. Torrence and Linda Powell).

Index.

Rezensionen

"...will serve as an excellent foundation for persons interested in basic research in the field of antiviral drug development and new strategies for viral inhibition." (Clinical Infectious Diseases, February 2007)

Produkt-Details

• Erscheint lt. Verlag: 5.8.2005
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Allgemeines / Lexika
• Themenwelt: Medizin / Pharmazie ► Gesundheitsfachberufe
• Themenwelt: Studium ► 2. Studienabschnitt (Klinik) ► Pathologie
• Themenwelt: Naturwissenschaften ► Chemie ► Organische Chemie
• Schlagworte: Chemie • Chemistry • Medizinische Chemie • Methods - Synthesis & Techniques • Organische Chemie / Methoden, Synthesen, Verfahren
• ISBN-10: 0-471-71670-7 / 0471716707
• ISBN-13: 978-0-471-71670-9 / 9780471716709