Peptide and Protein Design for Biopharmaceutical Applications (eBook)

Knud J. Jensen (Herausgeber)

eBook Download: PDF

2009 | 1. Auflage
306 Seiten
John Wiley & Sons (Verlag)
978-0-470-74971-5 (ISBN)

Infos

Peptides serve as effective drugs in the clinic today. However the
inherent drawbacks of peptide structures can limit their efficacy
as drugs. To overcome this researchers are developing new methods
to create 'tailor-made' peptides and proteins with
improved pharmacological properties.

Design of Peptides and Proteins provides an overview of
the experimental and computational methods for peptide and protein
design, with an emphasis on specific applications for therapeutics
and biomedical research. Topics covered include:

* Computer modeling of peptides and proteins

* Peptidomimetics

* Design and synthesis of cyclic peptides

* Carbohydrates in peptide and protein design

* De novo design of peptides and proteins

* Medical development applications

* An extended case study - the design of insulin
variants

Design of Peptides and Proteins presents the
state-of-the-art of this exciting approach for therapeutics, with
contributions from international experts. It is an essential
resource for academic and industrial scientists in the fields of
peptide and protein drug design, biomedicine, biochemistry,
biophysics, molecular modelling, synthetic organic chemistry and
medicinal/pharmaceutical chemistry.

Autor

Knud J. Jensen, University of Copenhagen, Faculty of Life Sciences, Denmark Professor Jensen's research interests cover synthetic bioorganic chemistry, peptide chemistry, carbohydrate chemistry, chemical protein synthesis, solid-phase synthesis and glycobiology.

Inhalt

List of Contributors.

Preface.

1. Introduction (Knud J. Jensen)..

2. Computational Approaches in Peptide and Protein Design: An
Overview (Garland Marshall and Gregory
Nikiforovich)..

2.1 Introduction.

2.2 Basics and Tools.

2.3 Computational Study of Cyclopentapeptide Inhibitors of
CXCR4.

Acknowledgements.

References.

3. Aspects of Peptidomimetics (VeroniqueMaes and Dirk
Tourwe)..

3.1 Introduction.

3.2 Modified Peptides.

3.3 Pseudopeptides.

3.4 Secondary Structure Mimics (Excluding Turn Mimics).

3.5 Examples of Peptidomimetics.

3.6 Conclusion.

References.

4. Design of Cyclic Peptides (Oliver Demmer, A.
O. Frank, and Horst Kessler)..

4.1 Introduction.

4.2 Peptide Cyclization.

4.3 Conformation and Dynamics of Cyclic Peptides.

4.4 Concepts in Rational Design of Cyclic Peptides.

4.5 Examples of Cyclic Peptides as Drug Candidates.

4.6 Conclusion.

References.

5. Carbohydrates in Design of Peptides and Proteins
(Knud J. Jensen and Jesper Brask)..

5.1 Introduction.

5.2 Configurational and conformational Properties of
Carbohydrates.

5.3 Carbohydrates in Peptidomimetics.

5.4 Glycopeptides.

5.5 Carbohydrates as Scaffolds in the Design of Non-Peptide
Peptidomimetics.

5.6 Sugar Amino Acids.

5.7 Cyclodextrin-Peptide Conjugate .

5.8 Carboproteins: Model Proteins on Carbohydrate Templates.

5.9 Conclusion Remarks.

6. De Novo design of proteins (Knud J.
Jensen)..

6.1 Introduction.

6.2 Secondary Structure Elements.

6.3 Assembling a Specified Tertiary Structure from Secondary
Structure Elements.

6.4 Proteins on Templates.

6.5 Foldamers.

6.6 Biopharmaceutical Applications of Protein De Novo
Design.

References.

7. Design of Insulin Variants for Improved Treatment of
Diabetes (Thomas Høeg-Jensen)..

7.1 Introduction.

7.2 Diabetes Management and the Need for Insulin
Engineering.

7.3 Insulin Structure.

7.4 Prolonged-acting Insulin Solids.

7.5 Prolonged-acting Insulin Solutions.

7.6 Fast-acting Insulins.

7.7 Glucose-sensitive Insulin Preparations.

7.8 Alternative Insulin Delivery.

7.9 Insulin Mimetics.

7.10 Pushing the Limitations of Insulin Engineering.

7.11 Conclusion.

References.

Index..

Rezensionen

"This book provides a comprehensive review of the many approaches
undertaken over the yearsto develop peptide-based and
peptide-mimetic-based drugs." (Journal of Medicinal
Chemistry, June 2010)

Produkt-Details

• Erscheint lt. Verlag: 1.9.2009
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Pflege
• Themenwelt: Medizin / Pharmazie ► Physiotherapie / Ergotherapie ► Orthopädie
• Themenwelt: Naturwissenschaften ► Biologie ► Biochemie
• Themenwelt: Naturwissenschaften ► Chemie
• Themenwelt: Technik ► Medizintechnik
• Schlagworte: Biochemie • Biochemie u. Chemische Biologie • Biochemistry (Chemical Biology) • Biopharmazie • Biowissenschaften • Chemie • Chemistry • Life Sciences • Pharmaceutical & Medicinal Chemistry • Pharmazeutische Chemie • Pharmazeutische u. Medizinische Chemie • Proteine u. Makromoleküle • Proteine u. Makromoleküle • Proteins & Macromolecules
• ISBN-10: 0-470-74971-7 / 0470749717
• ISBN-13: 978-0-470-74971-5 / 9780470749715