Local Control of Microvascular Perfusion
Seiten
2012
Morgan & Claypool Publishers (Verlag)
978-1-61504-436-8 (ISBN)
Morgan & Claypool Publishers (Verlag)
978-1-61504-436-8 (ISBN)
Discusses each vasoregulatory phenomena while also considering evidence for their underlying cellular mechanisms. Further, an attempt is made to integrate the information into complex in vivo situations and consider their relevance to pathophysiological situations.
Local control of microvascular perfusion refers to the ability of individual tissues to maintain a relative constancy of hemodynamics in the face of changing perfusion pressure while meeting metabolic demands appropriately. The regulation of local blood flow, or autoregulation, and its underlying mechanisms have been a subject of considerable interest for over 100 years. Particular focus has been placed on the acute interaction of myogenic (pressure-induced) and metabolic (local production of vasodilator metabolites) parameters and how they interact with flow (shear stress)-dependent and conduction-based mechanisms to produce integrated local vascular network responses (for example, as seen during reactive and functional hyperemia). This monograph discusses each of these vasoregulatory phenomena while also considering evidence for their underlying cellular mechanisms. Further, an attempt is made to integrate the information into complex in vivo situations and consider their relevance to pathophysiological situations.
Local control of microvascular perfusion refers to the ability of individual tissues to maintain a relative constancy of hemodynamics in the face of changing perfusion pressure while meeting metabolic demands appropriately. The regulation of local blood flow, or autoregulation, and its underlying mechanisms have been a subject of considerable interest for over 100 years. Particular focus has been placed on the acute interaction of myogenic (pressure-induced) and metabolic (local production of vasodilator metabolites) parameters and how they interact with flow (shear stress)-dependent and conduction-based mechanisms to produce integrated local vascular network responses (for example, as seen during reactive and functional hyperemia). This monograph discusses each of these vasoregulatory phenomena while also considering evidence for their underlying cellular mechanisms. Further, an attempt is made to integrate the information into complex in vivo situations and consider their relevance to pathophysiological situations.
Abbreviations
Acknowledgments
Introduction
Historical Perspectives
Microcirculatory Elements Affecting Blood Flow Control
Autoregulation
Myogenic Vasoconstriction and Dilation
Metabolic Control of Blood Flow
Endothelial-Mediated Mechanisms of Local Blood Flow Regulation
Interactions Between Local Control Mechanisms
Interactions with Extrinsic Control Mechanisms
Vascular Heterogeneity
Alterations in Microvascular Blood Flow Control in Pathophysiology
Long-Term Regulation of Blood Flow
Summary
References
Author Biographies
| Erscheint lt. Verlag | 30.10.2012 |
|---|---|
| Reihe/Serie | Colloquium Series on Integrated Systems Physiology |
| Verlagsort | San Rafael |
| Sprache | englisch |
| Maße | 191 x 235 mm |
| Gewicht | 333 g |
| Themenwelt | Studium ► 1. Studienabschnitt (Vorklinik) ► Anatomie / Neuroanatomie |
| Studium ► 1. Studienabschnitt (Vorklinik) ► Physiologie | |
| Naturwissenschaften ► Biologie ► Humanbiologie | |
| ISBN-10 | 1-61504-436-1 / 1615044361 |
| ISBN-13 | 978-1-61504-436-8 / 9781615044368 |
| Zustand | Neuware |
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