Molecular Aspects of Potential New Therapies for Neuroendocrine Tumors

Special Topic Issue: Neuroendocrinology 2013, Vol. 97, No. 1

Buch | Softcover

114 Seiten

2013
Karger, S (Verlag)
978-3-318-02296-4 (ISBN)

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Neuroendocrine tumors (NETs) are characterized by both chemoresistance and long-term survival even in metastatic disease. NETs secrete biogenic amines and/or peptide hormones causing hormonal symptoms. They express a variety of peptide receptors, receptor tyrosine kinases relevant for tumor growth and angiogenesis, and intracellular targets of importance for tumor growth and apoptosis, e.g. mTOR. Receptors for epidermal growth factor, transforming growth factor and connective tissue growth factor including their ligands could be future therapeutic targets. It has only recently been claimed that neuroendocrine cancer stem cells were isolated and some activated signaling pathways disclosed. Studies of signaling pathways for therapeutic interventions have been hampered by variable tumor subtypes and a relative shortage of human tumor cell lines. High throughput techniques have facilitated the molecular characterization of NETs beyond classic histopathology, demonstrating differences between pancreatic and ileal tumors, functioning and nonfunctioning tumors as well as differences in tumorigenesis. Candidate targets for therapy are increasingly evolving.

Erscheint lt. Verlag	13.2.2013
Zusatzinfo	23 fig., 14 in color, 13 tab.
Verlagsort	Basel
Sprache	englisch
Gewicht	387 g
Themenwelt	Medizinische Fachgebiete ► Innere Medizin ► Gastroenterologie
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Neurologie
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
Schlagworte	endocrinology • gastroenterology • Neuroendocrinology • Neuroendokrinologie • Neurology • Neuroonkologie • Oncology
ISBN-10	3-318-02296-9 / 3318022969
ISBN-13	978-3-318-02296-4 / 9783318022964
Zustand	Neuware