Ligand Efficiency Indices for Drug Discovery
Towards an Atlas-Guided Paradigm
Seiten
2013
Academic Press Inc (Verlag)
978-0-12-404635-1 (ISBN)
Academic Press Inc (Verlag)
978-0-12-404635-1 (ISBN)
Emphasizes the use of 'new variables' and objective numerical methods to drive drug discovery in an encompassing way. This book provides a practical discussion of the concepts, ideas, applications and examples of efficiency-driven drug discovery.
The purpose of Ligand Efficiency Indices for Drug Discovery: Towards an Atlas-Guided Paradigm is to introduce in a concise and self-contained form the concepts, ideas, applications and examples of efficiency-driven drug discovery to the biomedical community at large. The book emphasizes the use of 'new variables' and more objective numerical methods to drive drug discovery in an encompassing way. These 'new variables' are based on Ligand Efficiency Indices (LEIs) formulated in a way that permits mapping Chemico-Biological Space (CBS) in an Atlas-like representation. It provides a practical and timely discussion of the concepts, ideas, applications and examples of efficiency-driven drug discovery. This book emphasizes the use of a graphical representation and objective numerical methods to drive drug discovery more effectively. It presents the definition of LEIs and the corresponding efficiency planes within an atlas-like environment to provide a robust graphical and numerical framework for medicinal chemists and drug-discoverers.
The purpose of Ligand Efficiency Indices for Drug Discovery: Towards an Atlas-Guided Paradigm is to introduce in a concise and self-contained form the concepts, ideas, applications and examples of efficiency-driven drug discovery to the biomedical community at large. The book emphasizes the use of 'new variables' and more objective numerical methods to drive drug discovery in an encompassing way. These 'new variables' are based on Ligand Efficiency Indices (LEIs) formulated in a way that permits mapping Chemico-Biological Space (CBS) in an Atlas-like representation. It provides a practical and timely discussion of the concepts, ideas, applications and examples of efficiency-driven drug discovery. This book emphasizes the use of a graphical representation and objective numerical methods to drive drug discovery more effectively. It presents the definition of LEIs and the corresponding efficiency planes within an atlas-like environment to provide a robust graphical and numerical framework for medicinal chemists and drug-discoverers.
IntroductionPART 1: The Elements: Data, Variables, Concept and the ServerPART 2: Conceptual Applications of the AtlasCBS: A New ParadigmPART 3: Exploring CBS: Practical Examples Using the AtlasCBS ServerReferencesEpilogueAppendix I. Appendix II.
| Verlagsort | San Diego |
|---|---|
| Sprache | englisch |
| Maße | 152 x 229 mm |
| Gewicht | 390 g |
| Themenwelt | Studium ► 2. Studienabschnitt (Klinik) ► Pharmakologie / Toxikologie |
| Naturwissenschaften ► Chemie ► Organische Chemie | |
| Technik ► Umwelttechnik / Biotechnologie | |
| ISBN-10 | 0-12-404635-5 / 0124046355 |
| ISBN-13 | 978-0-12-404635-1 / 9780124046351 |
| Zustand | Neuware |
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