Regulation of Aldosterone Biosynthesis

Physiological and Clinical Aspects

Jürg Müller (Autor)

Buch | Softcover

XV, 364 Seiten

2011 | 2nd ed. 1988. Softcover reprint of the original 2nd ed. 1988
Springer Berlin (Verlag)
978-3-642-83122-5 (ISBN)

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Sixteen years is a long time, not only in human life but also in the rapid history of contemporary endocrinology. Since the publication of the first edition of this monograph, numerous new lines of research and discoveries have greatly contrib uted to our knowledge of the physiological and pathological regulation of aldos terone biosynthesis in man and animals. The first reports about a sensitive ra dioimmunoassay for plasma aldosterone and about a preparation of dispersed zona glomerulosa cells were published in 1970 (Mayes et al. 1970; Haning et al. 1970). These two developments alone turned out to have a tremendous impact on research in aldosterone physiology (for reviews see Coghlan et al. 1979b; J. F. Tait et al. 1980b). In 1971, atrial natriuretic peptides, somatostatin, and the precursor molecule of ACTH had not yet been discovered. Angiotensin antagonists and con verting-enzyme inhibitors were not yet available. The clinical syndrome of hypo reninemic hypo aldosteronism was unknown. The possible roles of prostaglandins and dopamine in the control of aldosterone pwduction had not been considered. Cyclic AMP was then the only substance with a clearly established second-mes senger function.

Jürg Müller, Dr. sc. tech. ETH, seit 2005 Geschäftsführer der MKR Partner, Solothurn. Frühere Tätigkeiten: 1972 1978 Abteilungsleiter Systemanalyse bei der BBC Schweiz, 1978 1990 Direktor der Cement- und Kalkfabrik Wildegg und des Kraftwerks Rüchlig in Aarau, 1991 2004 Generaldirektor der Papierfabrik Biberist.

1 Zona Glomerulosa of the Adrenal Cortex: Source of Aldosterone.- 2 Pathway of Aldosterone Biosynthesis.- 2.1 Classical Pathway and Alternative Pathways.- 2.2 Corticosterone as an Intermediate Product.- 2.3 18-Hydroxycorticosterone: Intermediate Product or By-product?.- 2.4 Alternative Pathway Through 18-Hydroxy-11-deoxycorticosterone?.- 2.5 Deoxycorticosterone Secretion.- 3 Aldosterone Biosynthesis by Cell-Free Systems.- 4 Substances Directly Influencing Aldosterone Biosynthesis in Shortterm Incubation or Perfusion Experiments.- 4.1 Angiotensins.- 4.2 Monovalent Cations.- 4.3 Divalent Cations.- 4.4 ACTH, ACTH-related Peptides, and Other Pituitary Hormones.- 4.5 Amines.- 4.6 Prostaglandins and Inhibitors of Prostaglandin Biosynthesis.- 4.7 Aldosterone-Inhibiting Peptides.- 4.8 Specific Inhibitors of Steroidogenic Enzymes.- 4.9 Inhibitors of RNA or Protein Synthesis.- 4.10 Steroid Hormones.- 4.11 Ouabain.- 4.12 Miscellaneous Biological Substances with Direct Stimulatory or Inhibitory Effects on Aldosterone Biosynthesis.- 4.13 Site of Action of Stimulators or Inhibitors in the Biosynthetic Pathway.- 4.14 Primary Effects and Intracellular Mediation.- 5 Alterations in Aldosterone Biosynthesis and Secretion in Long-Term Experiments and Diseases.- 5.1Alterations in Sodium Intake or in Sodium Balance.- 5.2 Alterations in Potassium Intake or in Potassium Balance.- 5.3 Exogenous Angiotensin or Renin.- 5.4 Pharmacological Blockade of the Renin-Angiotensin System.- 5.5 Role of the Kidneys.- 5.6 Role of the Pituitary Gland.- 5.7 Dopaminergic Regulation of Aldosterone Secretion.- 5.8 Role of the Central Nervous System.- 5.9 Normal Life.- 5.10 Estrogens and Progestogens.- 5.11 Aspects of Negative Feedback Regulation.- 6 Conclusions.- 6.1 Multiplicity of Aldosterone-Stimulating Substances.- 6.2 "Adrenoglomerulotropins".- 6.3 Physiological Inhibitors of Aldosterone Biosynthesis.- 6.4 The Shrinking Black Box.- 6.5 Long-Term Regulation of Late Steps in Aldosterone Biosynthesis.- 6.6 A Matter of Time.- 6.7 Enzymology of the Final Steps in Aldosterone Biosynthesis.- 6.8 Predominance of the Renin-Angiotensin System in the Physiological Control of Aldosterone Secretion?.- 6.9 Multifactorial Control of Aldosterone Biosynthesis.- References.

Erscheint lt. Verlag	8.12.2011
Reihe/Serie	Monographs on Endocrinology
Zusatzinfo	XV, 364 p.
Verlagsort	Berlin
Sprache	englisch
Maße	170 x 244 mm
Gewicht	660 g
Themenwelt	Medizinische Fachgebiete ► Innere Medizin ► Endokrinologie
Schlagworte	ACTH • Aldosterone • biosynthesis • endocrinology • Glucocorticoid • growth • growth hormone • Hormone • Hypophyse • Metabolism • Peptides • Prolactin • Protein • Regulation • Steroid • thyroid hormone
ISBN-10	3-642-83122-2 / 3642831222
ISBN-13	978-3-642-83122-5 / 9783642831225
Zustand	Neuware