Hyperthermia and the Therapy of Malignant Tumors

Buch | Softcover

X, 208 Seiten

2011 | 1. Softcover reprint of the original 1st ed. 1987
Springer Berlin (Verlag)
978-3-642-82957-4 (ISBN)

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Tumour therapy depends essentially on being able to destroy the clonogenic activity of tumour cells while keeping the damage to the normal tissue low. Clinical experience shows that tumour response varies greatly even if tumours with the same localisation, clinical, and histopathological staging are compared. Some tumours appear to be resistant to conventional radiotherapy (X-rays, y-rays or fast electrons) or chemotherapy. In these cases new therapy modalities are necessary. Combined therapy modalities seem to have advan tages for some resistant tumours; one possibility of such a treatment is to combine radiotherapy or chemotherapy with hyperthermia. This means that the local tumour, the tumour region or even the whole body of the patient has to be heated to temperatures between 40° to 45° C (in case of whole body hyperthermia to 42° C maximal) for a certain time (usually 30-60 min are adequate). Hyperthermia has a long tradition in medicine as a treatment modality for various diseases. Inscriptions of the old Egyptians and texts of the Greeks have pointed out its importance. Usually whole body hyperthermia has been used by the induction of fever. Local hyperthermia began around 1900 when Westermark treated unre sectable cervix carcinomas with hot water in a metallic coil. By the beginning of this century an increase of radiation effects was hy pothesised with hypothermia and later observed. However, only in the 1960s and 1970s were systematic investigations started which showed radiosensitisation and chemosensitisation by hyperthermia in cells and tissues including tumours.

Heat Delivery and Thermometry in Clinical Hyperthermia.- The Biological Basis for Tumour Therapy by Hyperthermia and Radiation.- Physiological Effects of Hyperthermia.- The Combination of Hyperthermia and Radiation: Clinical Investigations.- Hyperthermia and Drugs.

Erscheint lt. Verlag	8.12.2011
Reihe/Serie	Recent Results in Cancer Research
Mitarbeit	Assistent: R. Engelhardt, J.W. Hand, F. Kallinowski, M. Molls, E. Scherer, C. Streffer, D. van Beuningen, P. Vaupel
Zusatzinfo	X, 208 p.
Verlagsort	Berlin
Sprache	englisch
Maße	170 x 244 mm
Gewicht	387 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Radiologie / Bildgebende Verfahren
Schlagworte	carcinoma • Chemotherapy • hyperthermia • Radiation • Radiaton Oncology • radiotherapy • Staging • Tumor
ISBN-10	3-642-82957-0 / 3642829570
ISBN-13	978-3-642-82957-4 / 9783642829574
Zustand	Neuware