The Human Thymus

Histophysiology and Pathology

Buch | Softcover

X, 278 Seiten

2012 | 1. Softcover reprint of the original 1st ed. 1986
Springer Berlin (Verlag)
978-3-642-82482-1 (ISBN)

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Twenty-five years have passed since J. MILLER'S basic work on the central role of the thymus for the generation of immunological reactivi ty. During this time, the abundance of fascinating literature on the immunological and functional aspects of this organ has been in contrast to the paucity of reports on its role in pathology. The causal or formal pathogenesis even of many of the well-documented pathological fea tures is so far unexplained or at least uncertain. In spite of some concep tual progress related to the work of CASTLEMAN, LEVINE, and ROSAI, we regrettably have to say that in pathology the thymus remains almost as inconspicuous as 25 years ago. Only the new techniques developed in recent years have made it possible to look as closely into the complicated structural organization of the thymus as it appears to be necessary to observe and document abnormalities. Major steps have been taken with the advent of mono clonal antibody immune histochemistry and with detailed ultrastructur al studies in embryology. At this point, pathologists and researchers with a special interest in the thymus were asked to give overviews of their respective fields of interest in light of recent findings in immunology and basic insights into the structural-functional interrelationship of the human thymus. The results of this initiative have been brought together in this volume.

The Development of the Human Thymus Microenvironment.- Changes in the Human Thymus During Aging.- Cellular Differentiation of Lymphoid Subpopulations and Their Microenvironments in the Human Thymus.- Thymic Atrophy and Immune Deficiency in Malnutrition.- Pathology of the Thymus in Immunodeficiency States.- The Thymus in Myasthenia Gravis.- Pathology of Thymic Epithelial Tumors.

Erscheint lt. Verlag	10.1.2012
Reihe/Serie	Current Topics in Pathology
Co-Autor	M. Bofill, M. Chilosi, N. Dourov, B.v. Gaudecker, G. Janossy, M. Marino, H.K. Müller-Hermelink, C. Nezelof, G. Palestro, G.G. Steinmann, L.K. Trejdosiewicz, H. Wekerle, H.N.A. Willcox
Zusatzinfo	X, 278 p. 85 illus.
Verlagsort	Berlin
Sprache	englisch
Maße	170 x 244 mm
Gewicht	507 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete
Themenwelt	Studium ► 2. Studienabschnitt (Klinik) ► Pathologie
Schlagworte	Embryo • pathogenesis • Pathology • Thymus
ISBN-10	3-642-82482-X / 364282482X
ISBN-13	978-3-642-82482-1 / 9783642824821
Zustand	Neuware