Auto-immunity in the Endocrine System

R. Volpe (Autor)

Buch | Softcover

X, 188 Seiten

2011 | 1. Softcover reprint of the original 1st ed. 1981
Springer Berlin (Verlag)
978-3-642-81626-0 (ISBN)

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The present monograph will concern itself with those disorders of the endocrine system, either associated with destruction, interference with function or hyper function, which are considered to be due to auto-immune processes. Endocrinopathies Non-endocrine auto-immune disorders associated with the endocrinopathies Graves' (Basedow's, Parry's) disease Pernicious anaemia Hashimoto's thyroiditis Vitiligo Idiopathic Addison's disease Myaesthenia gravis Insulinopenic diabetes mellitus Sjogren's syndrome Auto-immune oophoritis and orchitis Rheumatoid arthritis Auto-immune hypoparathyroidism Idiopathic thrombocytopenic purpura Auto-immune hypophysitis Chronic active hepatitis Possibly some cases of infertility Primary biliary cirrhosis due to anti-sperm antibodies Reproduced with permission from Volpe (1977) The above table indicates those organ-specific endocrinopathies considered to be due to auto-immune factors, as well as those non-endocrine, organ-specific auto-immune disorders which may be associated with them (Volpe 1977). It is evident that such disorders, occurring without any obvious external cause, raise the very elementary question of how immune processes directed against self constituents could be initiated. Generally, of course, the immune system acts as a regulatory and defence mechanism, and disorders of auto-immunity represent breakdowns in this regulatory system. The following chapters will be concerned with the individual components ofthe endocrine system so affected by auto-immune processes; it will first be necessary to provide an initial chapter for the purpose of summarizing some general principles of immunology, in order to place the immune disorders of the endocrine system in context.

1 General Principles of Immunology (as Related to Auto-immune Disease).- 1.1 Immunity and the Immune Response.- 1.2 References.- 2 Auto-immunity in Thyroid Disease.- 2.1 Introduction.- 2.2 Studies of the Immunological Aspects of Thyroid Disease.- 2.3 Summary.- 2.4 References.- 3 Auto-immunity in Diabetes Mellitus.- 3.1 Introduction.- 3.2 Genetics.- 3.3 HLA Antigens in Type I Diabetes.- 3.4 Relationship to Other Organ-specific Auto-immune Diseases.- 3.5 Immunologic Disturbances.- 3.6 The Possible Role of Viruses in the Induction of Insulinopenic Diabetes.- 3.7 The Role of Immunity in the Pathogenesis of Complications of Diabetes Mellitus.- 3.8 Immunological Aspects of Islet and Pancreas Transplantation in Diabetes.- 3.9 Summary.- 3.10 References.- 4 Auto-immunity of the Anterior Pituitary.- 4.1 References.- 5 Auto-immune Diseases of the Adrenals, Gonads and Parathyroids: Auto-immune Polyendocrine Disease.- 5.1 Addison's Disease.- 5.2 Experimental Auto-immune Adrenalitis.- 5.3 Pathology of Idiopathic Addison's Disease.- 5.4 Humoral Immunity in Human Addison's Disease.- 5.5 Cell-mediated Immunity in Addison's Disease.- 5.6 Genetic Aspects of Auto-immune Addison's Disease.- 5.7 Other Organ-specific Auto-immune Diseases Associated with Idiopathic Addison's Disease.- 5.8 Polyendocrine Auto-immune Disease.- 5.9 Other Possible Auto-immune Endocrinopathies.- 5.10 Summary.- 5.11 References.- 6 Immunological Aspects of Male Infertility.- 6.1 References.- 7 Epilogue.- 7.1 Introduction.

Erscheint lt. Verlag	16.12.2011
Reihe/Serie	Monographs on Endocrinology
Zusatzinfo	X, 188 p. 1 illus.
Verlagsort	Berlin
Sprache	englisch
Maße	170 x 244 mm
Gewicht	361 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Dermatologie
	Medizinische Fachgebiete ► Innere Medizin ► Endokrinologie
	Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
Schlagworte	Autoaggressionskrankheit • Diabetes • Diabetes mellitus • Endokrinologie • immunity
ISBN-10	3-642-81626-6 / 3642816266
ISBN-13	978-3-642-81626-0 / 9783642816260
Zustand	Neuware