Major Sex-Determining Genes

S. Ohno (Autor)

Buch | Softcover

XIV, 142 Seiten

2011 | 1. Softcover reprint of the original 1st ed. 1979
Springer Berlin (Verlag)
978-3-642-81263-7 (ISBN)

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Upon wresting the control of the earth from the Titans, Zeus assigned the task of creating living creatures to two Titan brothers who had sided with him in the epic battle just concluded. Because Epimetheus, who had been endowed only with hindsight, had the first hand in this creation, all the good attributes were exhaus ted by the time the lion, the elephant and other animals were created. When the time came for the creation of man, there were precious few materials left to work with. Not surprisingly, man was made weak and naked. Prometheus took pity on this miscreation and gave man the use of fire. For this foresight, Zeus meted out horrible punishment, binding Prometheus to a rocky pillar in the Caucasas Moun tains and letting a vulture consume his liver daily. It seems to me that the ancient Greeks in their unfathomable wisdom under stood the essence of the evolutionary process very well. Had Escherichia coli of 200 million years or so ago been endowed with the foresight to anticipate the eventual emergence of and subsequent dominance by mammals of this Earth, they would no doubt have equipped themselves, in anticipation of the coming cer tainty, with the lac operon to deal with lactose in the suckling mammalian infant's gut. Had they been able to do so, the actual emergance of mammals would have exerted no selective pressure upon existing E. COLI.

I Sexual Dimorphism as a Dispensable Appendage of the Sex-Determining Mechanism.- 1 Why Sexual Dimorphism?.- 2 Man as a Sexually Dimorphic Species.- 3 Male Chauvinism and a Misunderstanding of Sexual Dimorphism.- II H-Y Antigen and Chromosomal Determination of Primary (Gonadal) Sex.- 4 The Number of Genes in the Mammalian Genome and the Need for Master Regulatory Genes.- 5 The Mammalian Sex Chromosomes.- 6 Initial Gonadal Differentiation and the History of H-Y Antigen.- 7 Testis-Organizing Function of H-Y Antigen.- 8 The Developmental Strategy of Competitive Displacements and the Role of ?2-Microglobulin-H-2 or HLA Dimers in Organogenesis.- 9 Testis-Organizing H-Y Antigen and the Cell Lineage-Specific Antigen of Testicular Sertoli and Ovarian Follicular Cells: H-2 Restricted and Nonrestricted Killing by Female T-Cells of Testicular Sertoli Cells.- 10 Why Are a Number of Unlinked Genes Involved in H-Y Antigen Expression?.- III Nuclear-Cytosol Androgen-Receptor Protein and Hormonal Secondary (Extragonadal) Sex Determination.- 11 The Inherently Feminine Embryonic Plan and Testosterone Induction of Male Secondary Sex.- 12 Abolition of All Androgen Target Organ Responses by the X-Linked Tfm (Testicular Feminization) Mutation.- 13 The Tfm Mutation Affects the Nuclear-Cytosol Androgen-Receptor Protein.- References.

Erscheint lt. Verlag	15.12.2011
Reihe/Serie	Monographs on Endocrinology
Zusatzinfo	XIV, 142 p. 10 illus.
Verlagsort	Berlin
Sprache	englisch
Maße	170 x 244 mm
Gewicht	288 g
Themenwelt	Medizinische Fachgebiete ► Innere Medizin ► Endokrinologie
	Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik
	Naturwissenschaften ► Biologie
Schlagworte	animals • genes • Sex
ISBN-10	3-642-81263-5 / 3642812635
ISBN-13	978-3-642-81263-7 / 9783642812637
Zustand	Neuware