Clinical Pharmacology in Psychiatry

From Molecular Studies to Clinical Reality

Svein G. Dahl, Lars F. Gram (Herausgeber)

Buch | Softcover

XIV, 329 Seiten

2011 | Softcover reprint of the original 1st ed. 1989
Springer Berlin (Verlag)
978-3-642-74432-7 (ISBN)

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This volume collects the invited lectures and some selected contributions presented at the 5th International Meeting on Clinical Pharmacology in Psychiatry, which was held 26-30 June 1988 at the University of Troms0, Norway. The 24 h of daylight at the northernmost university in the world al lowed for long, pleasant and productive sessions. The title of the conference as well as a number of the topics covered represent a continuation of four previous conferences, the first held in Chicago in 1979 and organized by the late Earl U sdin and colleagues. The earlier conferences have been documented in Clinical Pharmacology in Psychiatry, edited by E. Usdin (Elsevier, New York, 1981), Clinical Pharmacology in Psychiatry. Neuroleptic and Antidepressant Research, edited by E. Usdin, S. G. Dahl, L. F. Gram and o. Lingjrerde (Macmillan Publishers Ltd., London, 1981), Clinical Pharmacology in Psychiatry. Bridging the Experimental-Therapeutic Gap, edited by LF. Gram, E. Usdin, S.G. Dahl, P. Kragh-Sorensen, P. L. Morselli and F. Sjoqvist (Macmillan Publishers Ltd., London, 1983), and Clinical Pharmacology in Psychiatry. Selectivity in Psychotropic Drug Action - Promises or Problems? edited by S. G. Dahl, L.F. Gram, S.M. Paul and W.Z. Potter (Psychopharmacology Series 3, Springer, Heidelberg, 1987).

Strategies in Psychotropic Drug Innovation.- Receptor Subtypes and Endogenous Ligands: Rational Tools in the Search for Psychotropic Drugs?.- Histamine H3 Receptors in the Brain: Potent and Selective Ligands..- Targets for Neurotransmitter Receptor Research Using PET Scan: The Neuroleptic Binding Site..- The Potential of Positron-Emission Tomography for Pharmacokinetic and Pharmacodynamic Studies of Neuroleptics..- Neurotransmitter Interactions as a Target of Drug Action..- E-10-Hydroxynortriptyline: Effects and Disposition of a Potential Novel Antidepressant..- Molecular Graphics of Antidepressant Drugs and Metabolites..- Negative Symptoms in Schizophrenia: A Target for New Drug Development..- Clinical Significance of Receptor-Selective Drugs.- Clinical Effects of Selective Serotonin Reuptake Inhibitors..- Effects of Serotonergic Agonists on Neuroendocrine Responses of Rhesus Monkeys and Patients with Depression and Anxiety Disorders..- Theoretical and Practical Implications of a Controlled Trial of an ?2-Adrenoceptor Antagonist in the Treatment of Depression..- Selective Dopamine Dt and D2 Receptor Antagonists..- Animal Pharmacology of Raclopride, a Selective Dopamine D2 Antagonist..- Benzodiazepine Receptor Subtypes and Their Possible Clinical Significance..- Pharmacogenetics in Psychopharmacology.- Genetic Polymorphisms of Drug-Metabolizing Enzymes: Molecular Mechanisms..- Genetic Polymorphism in Drug Oxidation..- The Use of Human Liver Banks in Pharmacogenetic Research..- Inhibitors of the Microsomal Oxidation of Psychotropic Drugs: Selectivity and Clinical Significance..- Pharmacogenetics of Antidepressants..- Pharmacokinetic and Clinical Significance of Genetic Variability in Psychotropic Drug Metabolism..- Inhibition of Desipramine 2-Hydroxylation by Quinidineand Quinine in Rapid and Slow Debrisoquine Hydroxylators..- Debrisoquine Oxidation Phenotype in Psychiatric Patients..- Role of Pharmacogenetics in Drug Development..- Clinical Significance of Pharmacokinetic Variability.- Clinical Implications of the Pharmacokinetics of Tricyclic Antidepressants..- Detection of Populations at Risk Using Drug Monitoring Data..- Hydroxy Metabolites of Tricyclic Antidepressants: Evaluation of Relative Cardiotoxicity..- Therapeutic Drug Monitoring of Tricyclic Antidepressants: A Means of Avoiding Toxicity..- Neuroleptic Drug Levels in Erythrocytes and in Plasma: Implications for Therapeutic Drug Monitoring..- Active Metabolites of Neuroleptics in Plasma and CSF: Implications for Therapeutic Drug Monitoring..- Hydroxyhaloperidol and Clinical Outcome in Schizophrenia..- Plasma Level Monitoring for Maintenance Neuroleptic Therapy..- Perphenazine Serum Levels in Patients on Standard Doses..- Dose-Finding Problems with Psychotropic Drugs.- From Animal Experiments to Clinical Dosing: Some Aspects of Preclinical Development of Antidepressants..- Evaluation of Clinical and Biological Parameters in Healthy Volunteers: More than Pharmacokinetics and Side Effects?.- Dose Finding and Serum Concentrations of Neuroleptics in the Treatment of Schizophrenic Patients..- Post-Marketing Surveillance of Psychotropic Drugs..- List of Participants.

Erscheint lt. Verlag	10.12.2011
Reihe/Serie	Psychopharmacology Series
Zusatzinfo	XIV, 329 p.
Verlagsort	Berlin
Sprache	englisch
Maße	155 x 235 mm
Gewicht	521 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Psychiatrie / Psychotherapie
	Medizin / Pharmazie ► Pharmazie ► PTA / PKA
Schlagworte	clinical research • Drug • Kinetics • Metabolism • Pharmacogenetics • Pharmacokinetics • pharmacology • Psychiatric Disorder • Psychiatry • Psychogenetik • Psychokinetik • Psychopharmacology • Psychotropic drugs • Psychotropische Substanzen • receptor selectivity • Research • Rezeptor-Selektivität
ISBN-10	3-642-74432-X / 364274432X
ISBN-13	978-3-642-74432-7 / 9783642744327
Zustand	Neuware