Molecular Basis of Viral and Microbial Pathogenesis

April 9-11, 1987

Rudolf Rott, Werner Goebel (Herausgeber)

Buch | Softcover

IX, 185 Seiten

2011 | 1. Softcover reprint of the original 1st ed. 1988
Springer Berlin (Verlag)
978-3-642-73216-4 (ISBN)

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Elucidation of the mechanisms of pathogenesis underlying the diseases caused by viruses and bacteria has fascinated scientists for many years in two ways. Firstly, these pathogenic agents represent relatively sim ple biological systems for the study of basic biological processes such as replication, gene regulation, genetic variability and host-pathogen interactions. Secondly, process in this field is valuable in a practi cal sence, since it can help in the control of these diseases. The avail ability of new genetic and immunological techniques, especially recom binant DNA methods and monoclonal antibody technology, has provided powerful tools for unravelling the genetic, biochemical and immunologi cal basis of viral and microbial pathogenesis. Molecular cloning has allowed the isolation of single genes or groups of genes related to phenotypes which appear to be immunologically important for pathogene sis. The specific elimination of such genes from the complex genomes of the pathogens can now be achieved with similar genetic techniques. These genetic studies have provided additional information on the role played by specific phenotypic traits in pathogenesis, especially when combined with relevant animal model systems. Furthermore, the struc tural analysis of important virulence factors and surface antigens may allow the prediction of antigenic domains suitable for the development of new vaccines. The 38th Mosbacher Colloquium focuses on the molecular basis of viral and microbial pathogenesis. The virology part begins with the well studied plant viroids. The unusual structure of their genome, as well as knowledge about their replication and pathogenicity, are presented.

Correlation Between Viroid Structure and Pathogenicity.- Antigenicity of the Influenza Haemagglutinin Membrane Glycoprotein.- Viral Glycoproteins as Determinants of Pathogenicity.- Virus Genes Involved in Host Range and Pathogenicity.- Molecular Heterogeneity of Pathogenic Herpes Viruses.- Recombination of Foreign (Viral) DNA with the Host Genome Studies in Vivo and in a Cell-Free System.- Disorders of Cellular Neuro-Functions by Persistent Viral Infections.- Pathogenetic Aspects of Measles Virus-Persistent Infections in Man.- Analysis of the Dual Lineage Specificity of E26 Avian Leukemia Virus.- Mx Gene Control of Influenza Virus Susceptibility.- Shiga and Shiga-Like Toxins: A Family of Related Cytotoxins.- Molecular Mechanisms of Pathogenicity in Shigella flexneri.- Antigenic Variation of Proteins on the Surface of Pathogenic Neisseriae.- Molecular and Antigenic Architecture of the Antiphagocytic Group A Streptococcal M Protein.- Bacterial Cytolysins that Form Transmembrane Pores.- Bacterial Cytolysins - Extracellular Proteins and Virulence Factors.- Iron as a Signal in Bacterial Infections.- Clostridial Neurotoxins - The Search for a Common Mode of Action.- Stage-Specifically Expressed Antigens and Genes in Trypanosoma cruzi.

Erscheint lt. Verlag	10.12.2011
Reihe/Serie	Colloquium der Gesellschaft für Biologische Chemie in Mosbach Baden
Zusatzinfo	IX, 185 p. 25 illus.
Verlagsort	Berlin
Sprache	englisch
Maße	170 x 242 mm
Gewicht	345 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Mikrobiologie / Infektologie / Reisemedizin
Themenwelt	Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
Schlagworte	glycoprotein • leukemia virus • Molecular mechanisms • Protein • proteins • Regulation • Toxin • Trypanosoma cruzi • Virology • Virulence • Virus • Viruses • Vivo
ISBN-10	3-642-73216-X / 364273216X
ISBN-13	978-3-642-73216-4 / 9783642732164
Zustand	Neuware