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Antimalarial Drug II

Antimalarial Drug II

Current Antimalarial and New Drug Developments
Buch | Softcover
XVIII, 520 Seiten
2011 | 1. Softcover reprint of the original 1st ed. 1984
Springer Berlin (Verlag)
978-3-642-69256-7 (ISBN)
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The construction of this volume has been guided by two personal convictions. Experience in the field of experimental chemotherapy, both in the pharmaceutical industry and academia, has convinced us that recent quantum technological advances in biochemistry, molecular biology, and immunology will permit and, indeed, necessitate an increasingly greater use of rational drug development in the future than has been the custom up to now. In Part l, therefore, we asked our contributors to provide detailed reviews covering the biology of the malaria parasites and their relation with their hosts, the experimental procedures including culture techniques that are necessary to take a drug from primary screening to clinical trial, and an account of antimalarial drug resistance. Our second conviction is that many research workers are all too loath to learn from the lessons of the past. For this reason we asked the contributors to Part 2 of this volume to review very thoroughly the widely scattered but voluminous literature on those few chemical groups that have provided the antimalarial drugs in clinical use at the present time. Much can be learned from the history of their development and the problems that have arisen with them in man. Some indeed may still have much to offer if they can be deployed in better ways than they are at present. This question has been taken up by several authors.

Antimalarial Drugs in Current Use.- 1 4-Aminoquinolines.- 2 Quinine and Quinine Analogues.- 3 8-Aminoquinolines.- 4 Sulphonamides and Sulphones.- 5 Dihydrofolate Reductase Inhibitors.- Novel Methods of Drug Development.- 6 Drug Combinations.- 7 Repository Preparations.- 8 Cell Targeting of Primaquine.- Recent Developments in Antimalarials.- 9 Drugs with Quinine-like Action.- 10 8-Aminoquinolines.- 11 Lapinone, Menoctone, Hydroxyquinolinequinones and Similar Structures.- 12 4-Aminoquinolines and Mannich Bases.- 13 Triazines, Quinazolines and Related Dihydrofolate Reductase Inhibitors.- 14 Antibiotics.- 15 Miscellaneous Compounds.- Prevention of Drug Resistance.- 16 Use of Drug Combinations.

Erscheint lt. Verlag 7.12.2011
Reihe/Serie Handbook of Experimental Pharmacology
Co-Autor R. Baurain, P.E. Carson, R. Ferone, C.D. Fitch, W. Hofheinz, A.T. Hudson, R. Leimer, P. Mamalis, M. Masquelier, E.W. McChesney, B. Merkli, W. Peters, R.O. Pick, P. Pirson, R. Richle, K.H. Rieckmann, H.J. Scholer, T.R. Sweeney, A. Trouet, D. Warburton, L.M. Werbel, D.F. Worth
Zusatzinfo XVIII, 520 p.
Verlagsort Berlin
Sprache englisch
Maße 170 x 244 mm
Gewicht 926 g
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete Mikrobiologie / Infektologie / Reisemedizin
Medizin / Pharmazie Medizinische Fachgebiete Pharmakologie / Pharmakotherapie
Medizin / Pharmazie Pharmazie PTA / PKA
Schlagworte biochemistry • Biology • Chemistry • Chemotherapy • clinical trial • Drug • drug development • drug resistance • Drugs • immunology • Malaria • Molecular Biology • parasite • Research • resistance
ISBN-10 3-642-69256-7 / 3642692567
ISBN-13 978-3-642-69256-7 / 9783642692567
Zustand Neuware
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