Drug-Induced Hepatotoxicity
Springer Berlin (Verlag)
978-3-642-64657-7 (ISBN)
The advances in science and medicine we are now experiencing are unprec edented and exciting. Life expectancy is prolonged, and quality of life is much improved. We learn of fabulous new discoveries made at the bench or the bedside every week. Many diseases have been totally eliminated, others can be significantly improved by new therapeutic formulations. Much of the success can be attributed to a better understanding of disease processes and the specific targeting of new and more effective medications. As is the case in many areas of successful human endeavour, there can be a downside. In the case of drugs and chemicals it is their adverse effects which are of concern. Of course, every effort is made to devise medications that are safe, and the need to elucidate and understand mechanisms are crucial, yet adverse effects remain a problem. They can be unpredictable and diverse. Drugs have been shown to induce virtually the whole gamut of human liver pathology from acute fulminant hepatitis to chronic active hepatitis to cirrho sis and even malignancy. Hence the possibility of adverse drug effects must be considered in the differential diagnosis of many patients with liver disease. This is well recognized and is very important; indeed, removal of the offending agent can often lead to reversal of the adverse effect. This is an area of hepatology where we can really make a difference.
1: Orientation in Liver Toxicity by Drugs.- 2: Clinical Studies and Role of Necrosis in Hepatotoxicity (With 7 Figures).- 3: Subcellular Biochemical and Pathological Correlates in Experimental Models of Hepatotoxicity (With 5 Figures).- 4: Molecular Biology of Hepatic Drag Reactions (With 6 Figures).- 5: In Vitro Models of Liver Toxicity (With 4 Figures).- 6: Cytochromes P450 and Liver Injury (With 4 Figures).- 7: Mechanisms of Drug-Induced Cholestasis.- 8: Fatty Liver and Drugs (With 1 Figure).- 9: Choline Deficiency: An Important Model for the Study of Hepatotoxicity (With 2 Figures).- 10: Immune Mechanisms and Liver Toxicity (With 3 Figures).- 11: Hepatic Encephalopathy.- 12: Liver Drug Reactions and Pregnancy.- 13: Pediatric Hepatic Drug Reactions.- 14: Reye's Syndrome.- 15: Drug Hepatotoxicity in the Elderly (With 7 Figures).- 16: Effect of Liver Disease on Drug Metabolism and Pharmacokinetics (With 6 Figures).- 17: Liver Reactions to Tacrine (With 2 Figures).- 18: Mechanisms of Hypertransaminemia (With 7 Figures).- 19: Diagnostic Tools and Clinical Pathology.- 20: Antimicrobial Drugs (With 7 Figures).- 21: Hepatotoxicity of Cardiovascular Drugs (With 9 Figures).- 22: Analgesie Hepatopathy.- 23: Steroids and Other Hormones (With 7 Figures).- 24: Hepatotoxicity of Immunomodulating Agents.- 25: Alcohol-Induced Liver Injury.- 26: Antiepileptic Drugs (With 10 Figures).
| Erscheint lt. Verlag | 16.9.2011 |
|---|---|
| Reihe/Serie | Handbook of Experimental Pharmacology |
| Vorwort | M.J. Phillips |
| Zusatzinfo | XXXI, 681 p. |
| Verlagsort | Berlin |
| Sprache | englisch |
| Maße | 155 x 235 mm |
| Gewicht | 1070 g |
| Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie |
| Medizin / Pharmazie ► Pharmazie | |
| Schlagworte | Drug • hepatology • Hepatotoxizität • hepatoxicity • Leber • Liver • Metabolic disease • Reye's syndrome • Toxicity |
| ISBN-10 | 3-642-64657-3 / 3642646573 |
| ISBN-13 | 978-3-642-64657-7 / 9783642646577 |
| Zustand | Neuware |
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