Gap Junctions in the Brain
Physiological and Pathological Roles
Seiten
2012
Academic Press Inc (Verlag)
978-0-12-415901-3 (ISBN)
Academic Press Inc (Verlag)
978-0-12-415901-3 (ISBN)
Provides neuroscience researchers and students with a single source for information that covering the physiological, behavioral and pathophysiological roles of gap junctions in the brain. This book discusses human disease conditions associated with mutations in single gap junction connexion genes.
Gap junctions between glial cells or neurons are ubiquitously expressed in the mammalian brain and play a role in brain development including cell differentiation, cell migration and survival, and tissue homeostasis, as well as in human diseases including hearing loss, neuropathies, epilepsy, brain trauma, and cardiovascular disease. This volume provides neuroscience researchers and students with a single source for information covering the physiological, behavioral and pathophysiological roles of gap junctions in the brain. In addition, the book also discusses human disease conditions associated with mutations in single gap junction connexion genes, making it applicable to clinicians doing translational research. Finally, it includes reviews of pharmacological studies with gap junction blockers and openers, summarizing information obtained from phenotyping gap junctions mouse mutants.
Gap junctions between glial cells or neurons are ubiquitously expressed in the mammalian brain and play a role in brain development including cell differentiation, cell migration and survival, and tissue homeostasis, as well as in human diseases including hearing loss, neuropathies, epilepsy, brain trauma, and cardiovascular disease. This volume provides neuroscience researchers and students with a single source for information covering the physiological, behavioral and pathophysiological roles of gap junctions in the brain. In addition, the book also discusses human disease conditions associated with mutations in single gap junction connexion genes, making it applicable to clinicians doing translational research. Finally, it includes reviews of pharmacological studies with gap junction blockers and openers, summarizing information obtained from phenotyping gap junctions mouse mutants.
Ekrem Dere is full professor for the Pathophysiology of Cerebral Aging at the Pierre et Marie Curie University in Paris, France. His former team at the University in Düsseldorf, Germany, has provided the first behavioral evidence demonstrating that gap junctions in the brain play an important role in various behavioral processes.
Section I: Physiology of gap junctions in the brain
Section II: Gap junctions between astrocytes, neurons, and glia-neuron interactions
Section III: The role of gap junctions in brain development, neurogenesis and synaptic plasticity
Section IV: Gap junctions and neuronal synchronization
Section V: Gap junctions and neurological and neuropsychiatric diseases
Section VI: Gap junctions and behavior
| Verlagsort | San Diego |
|---|---|
| Sprache | englisch |
| Maße | 216 x 276 mm |
| Gewicht | 1100 g |
| Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Neurologie |
| Medizin / Pharmazie ► Medizinische Fachgebiete ► Psychiatrie / Psychotherapie | |
| ISBN-10 | 0-12-415901-X / 012415901X |
| ISBN-13 | 978-0-12-415901-3 / 9780124159013 |
| Zustand | Neuware |
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