Blick ins Buch

Microanatomy and Function of the Spleen

Birte Steiniger, Peter Barth (Autoren)

Buch | Softcover

VI, 96 Seiten

1999 | 1. Softcover reprint of the original 1st ed. 2000
Springer Berlin (Verlag)
978-3-540-66161-0 (ISBN)

Lese- und Medienproben

Inhaltsverzeichnis (PDF)

Artikel merken

This publication provides the first comprehensive review of human splenic microanatomy in correlation with up-to-date information on the immunological function of different splenic compartments. The authors provide an inter-species comparison of splenic microstructure in humans and rats to highlight the species-specific peculiarities of human spleens revealed by immunohistology. The finer structure of human B- and T-cell compartments and their surroundings is defined in detail based on the nomenclature established in rodent immunology. The authors review the typical microscopical features of an antibody response in the spleen of rodents. All information on vascular structures, lymphocytes, special macrophage and fibroblast populations is finally integrated into a hypothesis of lymphocyte recirculation through the human spleen.

5 Function of Splenic Compartments . . . . . . . . . . . . . . . 45 5. 1 Splenic White Pulp Compartments during Primary T Cell-Dependent Antibody Responses against Protein Antigens . . . . . . . . . . . . . . . . . . . . . . . . . 46 5. 1. 1 Priming of CD4+ Helper T Cells by Dendritic Cells in the PALS . . . . . . . . . . . . . . . . . . . . 46 Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 49 5. 1. 1. 1 5. 1. 2 Interaction of Primed CD4+ T Cells with Antigen-Specific B Cells in the PALS and Formation of Extrafollicular Foci . . . . . . . . . . . . . . . . . . . . . . . . . . . 49 5. 1. 2. 1 Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 50 5. 1. 3 Formation of Germinal Centres . . . . . . . . . . . . . . . . . . . 50 5. 1. 3. 1 Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 55 5. 1. 4 Localisation of Memory B Cells in the Marginal Zone . . . . . . . . . . . . . . . . . . . . . . . . . . . . 55 5. 1. 4. 1 Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 57 5. 2 Function of the Marginal Zone during Primary Antibody Responses against T Cell-Independent Type 2 Antigens . . . . . . . . 57 5. 2. 1 Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 59 Function of the Red Pulp . . . . . . . . . . . . . . . . . . . . . . . . . 59 5. 3 5. 3. 1 Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 61 5. 4 Role of the Spleen in CD8+ Cytotoxic T Cell Responses . . . . . . . . . . . . . . . 61 5. 4. 1 Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 62 The Spleen, Natural Killer Cells 5. 5 and Gamma/Delta T Cells . . . . . . . . . . . . . . .. . . . . . . . . 62 5. 5. 1 Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 63 6 Recirculation of Lymphocytes Through the Spleen . . 65 6. 1 Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 67 7 The Role of Cytokines and Chemokines in the Development of Splenic Compartments . . . . . . 69 7. 1 Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 72 8 Unsolved Problems of Human Splenic Structure and Function . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 73 VI 8. 1 Arterial Blood Supply to the Splenic Follicles and to the Perifollicular Zone. . . . . . . . . . . . . . . . . 73 . . . . 8. 1. 1 Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 74 8.

1 Introduction.- 2 Materials and Methods.- 2.1 Animal Spleens.- 2.2 Human Spleens.- 2.3 Antibodies.- 2.4 Single Staining Procedure for Immunohistology.- 2.5 Double Staining Procedure for Immunohistology.- 2.6 Demonstration of Acid Phosphatase in Cryostat Sections.- 2.7 Demonstration of Alkaline Phosphatase in Cryostat Sections.- 3 Microanatomical Compartments of the Rat Spleen.- 3.1 White Pulp.- 3.2 Red Pulp and Splenic Vessels.- 3.3 Summary.- 4 Microanatomical Compartments of the Human Spleen.- 4.1 White Pulp.- 4.2 Red Pulp and Splenic Vessels.- 4.3 Summary.- 5 Function of Splenic Compartments.- 5.1 Splenic White Pulp Compartments during Primary T Cell-Dependent Antibody Responses against Protein Antigens.- 5.2 Function of the Marginal Zone during Primary Antibody Responses against T Cell-Independent Type 2 Antigens.- 5.3 Function of the Red Pulp.- 5.4 Role of the Spleen in CD8+ Cytotoxic T Cell Responses.- 5.5 The Spleen, Natural Killer Cells and Gamma/Delta T Cells.- 6 Recirculation of Lymphocytes Through the Spleen.- 6.1 Summary.- 7 The Role of Cytokines and Chemokines in the Development of Splenic Compartments.- 7.1 Summary.- 8 Unsolved Problems of Human Splenic Structure and Function.- 8.1 Arterial Blood Supply to the Splenic Follicles and to the Perifollicular Zone.- 8.2 Blood Circulation in the Splenic Red Pulp: Subpopulations of Fibroblasts and their Role.- 8.3 Function of Sheathed Capillaries.- 8.4 Lymphocyte Migration in the Human Splenic White Pulp - A Hypothesis.- 9 Summary.- References.

Erscheint lt. Verlag	20.9.1999
Reihe/Serie	Advances in Anatomy, Embryology and Cell Biology
Zusatzinfo	VI, 96 p. 21 illus., 19 illus. in color.
Verlagsort	Berlin
Sprache	englisch
Maße	155 x 235 mm
Gewicht	202 g
Themenwelt	Studium ► 1. Studienabschnitt (Vorklinik) ► Anatomie / Neuroanatomie
	Studium ► 2. Studienabschnitt (Klinik) ► Pathologie
	Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
Schlagworte	Antigen • Chemokine • human spleen • immunohistology • microanatomy • Migration • rat spleen • splenic function
ISBN-10	3-540-66161-1 / 3540661611
ISBN-13	978-3-540-66161-0 / 9783540661610
Zustand	Neuware