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Systemic Radiotherapy with Monoclonal Antibodies

Options and Problems

Heiner Bihl, M. Wannemacher (Herausgeber)

Buch | Hardcover
IX, 198 Seiten
1996
Springer Berlin (Verlag)
978-3-540-60209-5 (ISBN)

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TOC: Contents: High dose radioimmunotherapy in malignant lymphoma.- Treatment of patients with recurrent malignant gliomas with intratumoral radioimmunoconjugates.- Two approaches for enhancing radioimmunotherapy: emitters and hyperthermia.- Use of epidermal growth factor receptor-425 monoclonal antibodies radiolabeled with iodine-125 in the adjuvant tratment of patients with high grade gliomas of the brain, treatment of diffuse leptomeningeal malignanca by intrathecal injection of 131I-radioimmunoconjugates.- Higher efficiency of 131I-labeled anti-carcinoembryonic antigen-monoclonal antibodies (Fab')2 as compared to intact antibodies in radioimmunotherapy of established human colon carcinoma grafted in nude mice.- Problems and advances in the dosimetry of radionuclide targeted therapy.- Experimental radioimmunotherapy: biological effectiveness and comparison with external beam radiation.- Monoclonal antibodies in tumor therapy.- Use of radioimmunotherapy in combination with bioreductive agents.- Optimal therapeutic strategies for radioimmunotherapy.- Minimal residual disease.- Can preirradiation enhance tumor uptake of radiolabled pharmaceuticals?

Summary of contents:
1. High dose radioimmunotherapy in malignant lymphoma
2. Treatment of patients with recurrent malignant gliomas with intratumoural radioimmunoconjugates
3. Two approaches for enhancing radioimmunotherapy: emitters and hyperthermia
4. Use of epidermal growth factor receptor
5. 425 monoclonal antibodies radiolabelled with iodine-125 in the adjuvant treatment of patients with high grade gliomas of the brain, treatment of diffuse leptomeningal malignanca by intrathecal injection of 1311-radioimmunoconjugates
6. Higher efficiency of 1311-labeled anti-carcinoembryonic antigen-monoclonal antibodies (Fab')2 as compared to intact antibodies in radioimmunotherapy of established human colon carcinoma grafted in nude-mice
7. Problems and advances in the dosimetry of radionuclide targeted therapy
8. Experimental radioimmunotherapy: biological effectiveness and comparison with external beam radiation
9. Monoclonal antibodies in tumour therapy
10. Use of radioimmunotherapy in combination with bioreductive agents
11. Optimal therapeutic strategies for radioimmunotherapy
12. Minimal residual disease
13. Can preirradation enhance uptake of radiolabelled pharmaceuticals?

Reihe/Serie Recent Results in Cancer Research
Zusatzinfo 56 figs., 20 tabs.
Sprache englisch
Gewicht 442 g
Einbandart gebunden
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete
Schlagworte Antikörper • Dosimetrie • HC/Medizin/Klinische Fächer • Radioimmunologie • Strahlentherapie • Strahlentherapie / Radiotherapie
ISBN-10 3-540-60209-7 / 3540602097
ISBN-13 978-3-540-60209-5 / 9783540602095
Zustand Neuware
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