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Extracorporeal Photopheresis

Cellular Photoimmunotherapy

Hildegard T. Greinix, Robert Knobler (Herausgeber)

Buch | Hardcover

XII, 215 Seiten

2012
De Gruyter (Verlag)
978-3-11-027594-0 (ISBN)

Lese- und Medienproben

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Extracorporeal photopheresis (ECP) is the first FDA approved cellular photoimmunotherapy for cancer, namely cutaneous T-cell lymphoma, and has demonstrated efficacy in various diseases that have a suspected involvement of pathogenic T-cells including prevention and treatment of acute and chronic graft-versus-host disease, organ transplant rejection, selected autoimmune diseases and Sezary syndrome. In ECP, patient’s blood mononuclear cells are collected, exposed to ultraviolet light in the presence of extracorporeally administered liquid 8-methoxypsoralen and reinfused. Besides its considerable efficacy ECP has an exceptional safety profile, does not cause general immunosuppression and thus, does not increase risk of infectious complications and relapse of malignant disease. Exciting preclinical data and clinical observations provide insight into the mechanisms of action of ECP and support its immunomodulatory role. This book will provide an overview on the historical development of ECP, technical aspects for its use in various patient populations including children and adults, novel research findings both in preclinical models and in various patient cohorts and will stimulate further research in organ, tissue and cell transplantation and autoimmune disorders.

Univ. Prof. Dr. Hildegard T. Greinix, Prof. Dr. Robert Knobler, both Medical University of Vienna Departments of Internal Medicine I and Dermatology Vienna, Austria.

Erscheint lt. Verlag	14.9.2012
Zusatzinfo	50 col. ill., 16 b/w tbl.
Verlagsort	Berlin/Boston
Sprache	englisch
Maße	170 x 240 mm
Gewicht	570 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Dermatologie
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
	Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
Schlagworte	Adjuvant Therapy • Apoptosis • autoimmune disease • Autoimmune diseases • Blood • Boehme • Cancer • Cell • Clinical Medicine, other • complications • Dermatitis • Dermatology • Diseases • extrakorporale Therapie • Fetishism • Graft vs Host Disease • Immunosuppression • immunotherapy • Implant • Internist • Leukozyt • Lichttherapie • Liver • Lymphocytes • Lymphoma • Lymphoma, T-Cell, Cutaneous • Medical • Medizin • Oncology • Onkologie • Photochemotherapy • Photopherese • Photopheresis • prevention • Skin • Steroids • T ce • T Cell • therapy • Transplantation • Vaccination
ISBN-10	3-11-027594-5 / 3110275945
ISBN-13	978-3-11-027594-0 / 9783110275940
Zustand	Neuware