Molecular Defects in Cardiovascular Disease (eBook)

Naranjan S. Dhalla, Makoto Nagano, Bohuslav Ostadal (Herausgeber)

eBook Download: PDF

2011 | 2011
XVIII, 382 Seiten
Springer New York (Verlag)
978-1-4419-7130-2 (ISBN)

Infos

Molecular Defects in Cardiovascular Disease provides an in-depth discussion of the molecular mechanisms underlying the genesis of cardiovascular defects and the implications this has on current and emerging targeted therapeutics.  Divided into three sections, this book covers the scientific foundations of our present understanding as well as the array of clinical manifestations and their treatment.  The first section covers Molecular Mechanisms of Heart Disease, with discussion of the development of cardiovascular dysfunction.  The remaining two sections provide a more clinical focus.  The second, Cardiac Hypertrophy and Heart Failure deals with metabolic derangements, Ca²⁺ handling, and subcellular remodeling.  It illustrates the wide variety of molecular defects which may serve as targets associated with the transition from cardiac hypertrophy to advanced heart failure.  The third section, Hypertension and Diabetes, provides molecular rationale for the pathogenesis of hypertension and diabetic cardiomyopathy, as well as highlighting the importance of hormones toward this end. 

A necessary resource for clinicians and researchers, this book elucidates the experimental basis of the practice of cardiology.  It is the culmination of our advances in the understanding of cardiovascular molecular biology and a blueprint for the efficacious use of targeted therapies.

Inhalt

A.  Molecular Mechanisms in Heart Disease 1.   Calcium overloading-induced oxidative stress-mediated cellular and subcellular remodelingY. Cheema, A.U. Shahbaz, S.K. Bhattacharya, R.A. Ahokas, Y.Sun, I.C. Gerling and K.T. Weber 2.   Intracellular MMP-2:  Role in normal and diseased heartsN. Youssef and R. Schulz 3.   Control of the mesenchymal-derived cell phenotype by Ski and Meox2: A putative mechanism for post-developmental phenoconversion R.H. Cunnington, J.T. Wigle, J.M. Douville, D.H. Freed, D. Schaafsma, S. O’Connor, S. Gupta, S.G. Rattan, A. Halayko and I.M.C. Dixon 4.   Elevated Na+/H+ exchanger expression and its role in myocardial diseaseL. Fliegel 5.   Impact of perinatal chronic hypoxia on cardiac tolerance to acute ischemia B. Ostadal, I. Ostadalova, F. Kolar, I. Netuka, O. Szarszoi,  6.   Stem cell, microRNA and redox cyclingP. Mukhopadhay, N. Gurusamy and D.K. Das 7.   Cardiac cell therapy: Present and futureD.K. Singla B.  Cardiac Hypertophy and Heart Failure 8.   Macroscopic and microscopic aspects of cardiac dysfunction in congestive heart failure      H.E.D.J. ter Keurs 9.   Cardiac dysfunction and metabolism: Unravelling the molecular cross-talkV. Sharma and J.H. McNeill  10. Metabolic remodeling of the hypertrophied heartJ.M. Dai and M.F. Allard 11. Mechanisms for the regulation of phospholipase C gene expression in cardiac hypertrophyP.S. Tappia  12. Molecular changes in fatty acid oxidation in the failing heartJ.S. Jaswal, W. Keung, W. Wang, J.R. Ussher and G.D. Lopaschuk 13. Cardiolipin metabolism in experimental and human heart failureG.M. Hatch 14. Mechanisms underlying development of cardiomyocyte hypertrophy via Na-H exchange stimulationM. Karmazyn 15. The structural basis of cardiac dysfunction in human heart failureS. Hein, S. Kostin and J. Schaper 16. Hormonal mechanisms of cardiac remodeling in heart failureA.P. Babick, V. Elimban and N.S. Dhalla 17. Modulators of remodeling after myocardial infarctionB.I. Jugdutt 18. Phosphodiesterase-5 inhibitors in protection against doxorubicin-induced cardiomyopathyS. Koka and R.C. Kukreja C.  Hypertension and Diabetes 19. Molecular basis of pulmonary hypertension in left heart failureB. Raj, H.S. Pillai and C.C. Kartha 20. Modulation of Gi protein expression in hypertension: Molecular mechanismsM.B. Anand-Srivastava 21. Vascular dysfunction in heart diseaseR. Perrault and P. Zahradka 22. Cellular and molecular mechanisms associated with salicylate inhibition of intimal hyperplasia balloon catheter-induced vascular injuryS.N. Murthy, P.J. Kadowitz and D.B. McNamara 23. Involvement of growth factor receptor and non receptor protein tyrosine kinases in endothelin 1 and angiotensin II-induced signaling pathways in the cardiovascular system.G. Vardatsikos and A.K. Srivastava 24. Sarco/endoplasmic reticulum Ca2+ pump damage by oxidative stress: Implications for Ca2+ entryG. Akolkar and A.K. Grover 25. Obesity-hypertension: Leptin as the common link to cardiovascular and renal dysregulationS. Kshatriya, H. Kozman, D. Siddiqui, L. Bhatta, K. Liu, A. Salah, T. Ford, R. Michiel, R. Carhart and D. Villarreal 26. Cardiorenal protection in diabetes mellitusH. Vashistha, L.G. Meggs and A. Malhotra 27. Molecular mechanisms in the pathogenesis of diabetic cardiomyopathyS. Chakrabarti

Produkt-Details

• Erscheint lt. Verlag: 9.8.2011
• Zusatzinfo: XVIII, 382 p. 78 illus., 31 illus. in color.
• Verlagsort: New York
• Sprache: englisch
• Themenwelt: Medizinische Fachgebiete ► Innere Medizin ► Kardiologie / Angiologie
• Themenwelt: Studium ► 1. Studienabschnitt (Vorklinik) ► Biochemie / Molekularbiologie
• Schlagworte: Cardiac • Cardiovascular • genes • Genetics • heart
• ISBN-10: 1-4419-7130-0 / 1441971300
• ISBN-13: 978-1-4419-7130-2 / 9781441971302