Mims' Medical Microbiology
W B Saunders Co Ltd (Verlag)
978-0-7234-3601-0 (ISBN)
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Mims' Microbiology makes it easy for you to learn the microbiology and basic immunology concepts you need to know for your courses and USMLE. Using a clinically relevant, systems-based approach, this popular medical textbook accessibly explains the microbiology of the agents that cause diseases and the diseases that affect individual organ systems. With lavish illustrations and straightforward, accessible explanations, Mims' Microbiology makes this complex subject simple to understand and remember.
Learn about infections in the context of major body systems and understand why these are environments in which microbes can establish themselves, flourish, and give rise to pathologic changes. This systems-based approach to microbiology employs integrated and case-based teaching that places the "bug parade" into a clinical context.
Grasp and retain vital concepts easily thanks to a user-friendly color-coded format, succinct text, key concept boxes, and dynamic illustrations.
Effectively review for problem-based courses with the help of chapter introductions and "Lessons in Microbiology" text boxes that highlight the clinical relevance of the material, offer easy access to key concepts, and provide valuable review tools.
Approach microbiology by body system or by pathogen through an extensively cross-referenced "Pathogen Review" section.
Access the complete contents online at studentconsult.com, along with downloadable illustrations.150 multiple choice review questions... "Pathogen Parade"...and many other features to enhance learning and retention.
Enhance your learning and absorb complex information in an interactive, dynamic way with Pathogen Parade - a quickly searchable online glossary of viruses, bacteria, and fungi.
Deepen your understanding of epidemiology and the important role it plays in providing evidence-based identification of key risk factors for disease and targets for preventive medicine. A completely re-written chapter on this topic keeps abreast of the very latest findings.
Preface v
Acknowledgements vi
Contributors vi
Student Consultants vii
A contemporary approach to microbiology xi
Microbes and parasites xi
The context for contemporary medical
microbiology xi
Microbiology past, present and future xii
The approach adopted in this book xiv
SECTION 1 THE ADVERSARIES - MICROBES
1. Microbes as parasites 3
The varieties of microbes 3
Living inside or outside cells 4
Systems of classification 5
2. The bacteria 7
Structure 7
Nutrition 9
Growth and division 10
Gene expression 11
Survival under adverse conditions 16
Mobile genetic elements 16
Mutation and gene transfer 20
The genomics of medically important bacteria 23
3. The viruses 27
Infection of host cells 27
Replication 29
Outcome of viral infection 31
Major groups of viruses 33
4. The fungi 37
Major groups of disease-causing fungi 37
5. The protozoa 41
6. The helminths and arthropods 43
The helminths 43
The arthropods 46
7. Prions 49
'Rogue protein' pathogenesis 49
Development, transmission and diagnosis
of prion diseases 50
Prevention and treatment of prion diseases 51
8. The host-parasite relationship 53
The normal flora 53
Symbiotic associations 56
The characteristics of parasitism 58
The evolution of parasitism 59
SECTION 2 THE ADVERSARIES-HOST DEFENCES
9. The innate defences of the body 67
Defence against entry into the body 67
Defences once the microorganism
penetrates the body 68
10. Adaptive responses provide a 'quantum leap'
in effective defence 83
The role of antibodies 83
The role of T lymphocytes 86
Extracellular attack on large infectious agents 89
Local defences at mucosal surfaces 90
11. The cellular basis of adaptive immune
responses 95
B- and T-cell receptors 98
Clonal expansion of lymphocytes 98
The role of memory cells 99
Stimulation of lymphocytes 101
Cytokines 102
Regulatory mechanisms 105
Tolerance mechanisms 106
SECTION 3 THE CONFLICTS
12. Background to the infectious diseases 111
Host-parasite relationships 111
Causes of infectious diseases 115
The biologic response gradient 117
13. Entry, exit and transmission 119
Sites of entry 119
Exit and transmission 125
Types of transmission between humans 127
Transmission from animals 132
14. Immune defences in action 137
Complement 137
Acute phase proteins and pattern
recognition receptors 137
Fever 139
Natural killer cells 139
Phagocytosis 139
Cytokines 142
Antibody-mediated immunity 144
Cell-mediated immunity 146
Recovery from infection 149
15. Spread and replication 153
Features of surface and systemic infections 154
Mechanisms of spread through the body 155
Genetic determinants of spread and replication 158
Other factors affecting spread and replication 159
16. Parasite survival strategies and persistent
infections 163
Parasite survival strategies 164
Antigenic variation 169
Immunosuppression 170
Persistent infections 173
17. Pathologic consequences of infection 179
Pathology caused directly by microorganism 179
Diarrhea 183
Pathologic activation of natural
immune mechanisms 183
Pathologic consequences of the
immune response 187
Skin rashes 191
Viruses and cancer 192
SECTION 4 CLINICAL MANIFESTATION AND
DIAGNOSIS OF INFECTIONS BY BODY SYSTEM
Introduction to Section 4: The clinical
manifestations of infection 197
18. Upper respiratory tract infections 199
Rhinitis 199
Pharyngitis and tonsillitis 200
Parotitis 208
Otitis and sinusitis 209
Acute epiglottitis 210
Oral cavity infections 210
19. Lower respiratory tract infections 213
Laryngitis and tracheitis 213
Diphtheria 213
Whooping cough 214
Acute bronchitis 215
Acute exacerbations of chronic bronchitis 216
Bronchiolitis 216
Respiratory syncytial virus infection 216
Hantavirus pulmonary syndrome (HPS) 217
Pneumonia 217
Bacterial pneumonia 218
Viral pneumonia 221
Parainfluenza virus infection 221
Adenovirus infection 223
Human metapneumovirus 223
Human bocavirus 223
Influenza virus infection 223
Severe acute respiratory syndrome-associated
coronavirus infection 228
Measles 229
Cytomegalovirus infection 230
Tuberculosis 230
Cystic fibrosis 233
Lung abscess 233
Fungal infections 234
Parasitic infections 235
20. Urinary tract infections 237
Acquisition and aetiology 237
Pathogenesis 238
Clinical features and complications 240
Laboratory diagnosis 241
Treatment 242
Prevention 243
21. Sexually transmitted infections 245
STIs and sexual behaviour 245
Syphilis 245
Gonorrhoea 249
Chlamydial infection 251
Other causes of inguinal lymphadenopathy 253
Mycoplasmas and non-gonococcal urethritis 255
Other causes of vaginitis and urethritis 255
Genital herpes 256
Human papillomavirus infection 257
Human immunodeficiency virus 257
Opportunist STIs 267
Arthropod infestations 267
22. Gastrointestinal tract infections 269
Diarrheal diseases caused by bacterial or viral
infection 270
Food poisoning 283
Helicobacter pylori and gastric ulcer disease 284
Parasites and the gastrointestinal tract 284
Systemic infection initiated in the
gastrointestinal tract 291
23. Obstetric and perinatal infections 303
Infections occurring in pregnancy 303
Congenital infections 303
Infections occurring around the time of birth 308
24. Central nervous system infections 311
Invasion of the central nervous system 311
The body's response to invasion 311
Meningitis 313
Encephalitis 319
Neurologic diseases of possible viral aetiology 324
Spongiform encephalopathies caused
by scrapie-type agents 324
CNS disease caused by parasites 324
Brain abscesses 325
Tetanus and botulism 326
25. Infections of the eye 329
Conjunctivitis 329
Infection of the deeper layers of the eye 332
26. Infections of the skin, soft tissue, muscle and
associated systems 335
Bacterial infections of skin, soft tissue and
muscle 337
Mycobacterial diseases of the skin 343
Fungal infections of the skin 345
Parasitic infections of the skin 350
Mucocutaneous lesions caused by viruses 351
Smallpox 358
Measles 358
Rubella 360
Other infections producing skin lesions 361
Kawasaki syndrome 361
Viral infections of muscle 361
Parasitic infections of muscle 362
Joint and bone infections 363
Infections of the haemopoietic system 365
27. Vector-borne infections 367
Arbovirus infections 367
Infections caused by rickettsiae 369
Borrelia infections 373
Protozoal infections 375
Helminth infections 380
28. Multisystem zoonoses 383
Arenavirus infections 383
Haemorrhagic fever with renal syndrome
(HFRS) 385Marburg and Ebola haemorrhagic fevers 385
Crimean-Congo haemorrhagic fever,
a tick-borne virus 385
Q fever 386
Anthrax 386
Plague 387
Yersinia enterocolitica infection 389
Tularemia 389
Pasteurella multocida infection 389
Leptospirosis 389
Rat-bite fever 390
Brucellosis 390
Helminth infections 391
29. Fever of unknown origin 395
Definitions of fever of unknown origin 395
Causes of FUO 395
Investigation of classic FUO 396
Treatment of FUO 399
FUO in specific patient groups 399
Infective endocarditis 400
30. Infections in the compromised host 403
The compromised host 403
Infections of the host with deficient innate
immunity due to physical factors 405
Infections associated with secondary adaptive
immunodeficiency 408
Other important opportunist pathogens 409
SECTION 5 DIAGNOSIS AND CONTROL
31. Diagnosis of infection and assessment of host
defense mechanisms 419
Aims of the clinical microbiology laboratory 419
Specimen processing 419
Non-cultural techniques for the laboratory
diagnosis of infection 420
Cultivation (culture) of microorganisms 428
Identification of microorganisms
grown in culture 429
Antibody detection methods for the
diagnosis of infection 432
Assessment of host defence systems 432
Putting it all together: detection, diagnosis,
and epidemiology 436
32. Epidemiology and control of infectious
diseases 439
Outcome measurements 439
Types of epidemiological studies 439
Transmission of infectious disease 444
Vaccine efficacy 446
33. Attacking the enemy: antimicrobial agents
and chemotherapy 447
Selective toxicity 447
Discovery and design of antimicrobial agents 447
Classification of antibacterial agents 448
Resistance to antibacterial agents 449
Classes of antibacterial agents 452
Inhibitors of cell wall synthesis 452
Inhibitors of protein synthesis 458
Inhibitors of nucleic acid synthesis 465
Antimetabolites affecting nucleic acid synthesis 467
Other agents that affect DNA 469
Inhibitors of cytoplasmic membrane function 469
Urinary tract antiseptics 470
Antituberculosis agents 470
Antibacterial agents in practice 471
Antibiotic assays 473
Antiviral therapy 473
Antifungal agents 481
Antiparasitic agents 483
Control by chemotherapy versus vaccination 483
Control versus eradication 487
Use and misuse of antimicrobial agents 487
34. Protecting the host: vaccination 491
vaccination - A four hundred year history 491
Aims of vaccination 491
Vaccines can be of different types 493
35. Passive and non-specific immunotherapy 505
Passive immunization with antibody 505
Non-specific cellular immunostimulation 508
Correction of host immunodeficiency 509
Probiotics 510
36. Hospital infection, sterilization and
disinfection 511
Common hospital infections 511
Important causes of hospital infection 511
Sources and routes of spread of
hospital infection 513
Host factors and hospital infection 514
Consequences of hospital infection 515
Prevention of hospital infection 517
Investigating healthcare-associated infection 521
Sterilization and disinfection 526
Online only - Pathogen parade
Bibliography 531
Index 539
| Zusatzinfo | Approx. 449 illustrations (449 in full color) |
|---|---|
| Verlagsort | London |
| Sprache | englisch |
| Maße | 216 x 276 mm |
| Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Mikrobiologie / Infektologie / Reisemedizin |
| ISBN-10 | 0-7234-3601-0 / 0723436010 |
| ISBN-13 | 978-0-7234-3601-0 / 9780723436010 |
| Zustand | Neuware |
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