HIV Interactions with Host Cell Proteins

Paul Spearman, Eric O. Freed (Herausgeber)

Buch | Softcover

X, 204 Seiten

2012 | 2009
Springer Berlin (Verlag)
978-3-642-26182-4 (ISBN)

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The study of viruses necessarily involves dissecting the intimate details of cellular pathways. Viruses have often been employed as tools in studying cellular pathways, as was done by early retrovirologists such as Peyton Rous in attempting to understand the mechanism of cellular transformation and oncogenesis. On the other side of the coin, virologists seek to de?ne those cellular elements interacting intimatelywiththeir virus ofinterestinorder to better understand viral replication itself, and in some cases to develop antiviral strategies. It is in the intersection of virology and cell biology that many of us ?nd the most rewarding aspects of our research. When a new discovery yields insights into basic cellular mechanisms and presents new targets for int- vention to ?ght a serious pathogen, the impact can be high and the excitement intense. HIV has been no exception to the rule that viruses reveal many basic aspects of cellular biology. In recent years, in part because of the importance of HIV as a major cause of human suffering, numerous cellular processes have been elucidated through work on processes or proteins of this human retrovirus. The excitement in this ?eld is especially well illustrated by the discovery of new innate means of resisting viral replication, such as the work on APOBEC3G, TRIM5a, and BST-2/ tetherin presented in this volume.

Preface.- Host restriction of HIV-1 by APOBEC3 and viral evasion through Vif.- Interactions of viral protein U (Vpu) with cellular factors.- TRIM5alpha.- Human Immunodeficiency virus type-1 Gag and host vesicular trafficking pathways.- The roles of tetraspanins in HIV-1 replication.- Imaging of HIV/host protein interactions.- Virological and cellular roles of the transcriptional coactivator LEDGF/p75.- Implications of Nef host cell interactions in viral persistences and progression to AIDS.- Vpr and its interactions with cellular proteins.- Subject index.

Erscheint lt. Verlag	1.3.2012
Reihe/Serie	Current Topics in Microbiology and Immunology
Zusatzinfo	X, 204 p. 26 illus., 20 illus. in color.
Verlagsort	Berlin
Sprache	englisch
Maße	155 x 235 mm
Gewicht	334 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Mikrobiologie / Infektologie / Reisemedizin
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
	Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
Schlagworte	AIDS • cellular vesicular trafficking • HIV • HIV-1 replication • Imaging • Retroviral Replication • tetherin • tetraspanins • transcriptional coactivator • Vaccine • viral immune evasion • viral infectivity factor (Vif) • Virus
ISBN-10	3-642-26182-5 / 3642261825
ISBN-13	978-3-642-26182-4 / 9783642261824
Zustand	Neuware