Methotrexate

Pharmacology, Clinical Uses & Adverse Effects

Valentina S Castillo, Laura A Moyano (Herausgeber)

Buch | Hardcover

266 Seiten

2012
Nova Science Publishers Inc (Verlag)
978-1-62100-596-4 (ISBN)

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Methotrexate (MTX) is an important component of therapy in several immune diseases (rheumatoid arthritis, psoriasis, and cancers such as acute lymphoblastic leukaemia, osteosarcoma, ovarian cancer and others). Despite its clinical success, treatment with MTX often causes toxicity, dose reduction or treatment cessation. In this book, the authors present topical research in the study of the pharmacology, clinical uses and adverse effects of methotrexate. Topics discussed include lipid alterations instigated by methotrexate; acute toxicity of high doses of methotrexate in the treatment of lymphoblastic leukaemia in children; pharmacogenetics update on MTHFR and methotrexate toxicity; animal models of cognitive impairment induced by methotrexate and damage, as well as the recovery of the bone and bone marrow following methotrexate chemotherapy.

Preface; Lipid Alterations Instigated by Methotrexate & Leucovorin in Female Reproductive Tract of Albino Rats; Acute Toxicity of High Doses of Methotrexate in the Treatment of Linfoblastic Leukemia in Children: A Case Report; Pharmacogenetics Update on MTHFR & Methotrexate Toxicity; Methotrexate: Pharmacology, Clinical Uses & Adverse Effects; Low Dose Methotrexate: Pharmacology, Clinical Uses & Adverse Effects; Methotrexate: Update on Pharmacology, Clinical Applications & Warnings; Factors Predicting Clinical Adverse Events during High-Dose Methotrexate Therapy; Animal Models of Cognitive Impairment Induced by Methotrexate; Damage & Recovery of the Bone & Bone Marrow Following Methotrexate Chemotherapy; The Effects of -glucan Isolated from Pleurotus otreatus on Methotrexate Treatment in Rats with Adjuvant Arthritis; Methotrexate: Pharmacology, Clinical Application & Adverse Effects; Molecular Mechanisms of Methotrexate Resistance; Index.

Verlagsort	New York
Sprache	englisch
Maße	180 x 260 mm
Gewicht	652 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
ISBN-10	1-62100-596-8 / 1621005968
ISBN-13	978-1-62100-596-4 / 9781621005964
Zustand	Neuware