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Small Molecules in Oncology -

Small Molecules in Oncology

Uwe M. Martens (Herausgeber)

Buch | Softcover
XVI, 238 Seiten
2012 | 2010
Springer Berlin (Verlag)
978-3-642-26145-9 (ISBN)
CHF 164,70 inkl. MwSt
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Written by acknowledged experts, this text provides a broad overview of the small molecules currently used for the treatment of malignant diseases, and discusses interesting novel compounds that are in the process of clinical development to combat cancer.

Extensive research into the molecular mechanisms of cancer disease has heralded a new age of targeted therapy. In malignant cells, key proteins that are crucial to tumor growth and survival are now being targeted directly with rationally designed inhibitors. Apart from monoclonal antibodies, small molecule therapeutics such as oncogenic protein kinase inhibitors are attracting a vast amount of investigational attention. This textbook, written by acknowledged experts, provides a broad overview of the small molecules currently used for the treatment of malignant diseases and discusses interesting novel compounds that are in the process of clinical development to combat cancer.

Protein kinase inhibitors.- Imatinib Mesylate.- Erlotinib.- Axitinib (AG-013736).- Lapatinib.- Sorafenib.- Sunitinib.- Dasatinib.- Nilotinib.- Bosutinib.- Epigenetic modifiers.- Decitabine.- 5-Azacytidine/Azacitidine.- Cell cycle inhibitors.- Bortezomib.- Temsirolimus.- Danusertib (formerly PHA-739358) - A Novel Combined Pan-Aurora Kinases and Third Generation Bcr-Abl Tyrosine Kinase Inhibitor.- BI_2536 - Targeting the Mitotic Kinase Polo-Like Kinase 1 (Plk1).- Other novel agents.- Imetelstat (GRN163L) - Telomerase-Based Cancer Therapy.- GDC-0449 - Targeting the Hedgehog Signaling Pathway.

Erscheint lt. Verlag 4.5.2012
Reihe/Serie Recent Results in Cancer Research
Zusatzinfo XVI, 238 p.
Verlagsort Berlin
Sprache englisch
Maße 155 x 235 mm
Gewicht 392 g
Themenwelt Medizinische Fachgebiete Innere Medizin Hämatologie
Medizin / Pharmazie Medizinische Fachgebiete Onkologie
Schlagworte Molecular mechanisms of cancer • Oncogenic protein kinase inhibitors • targeted therapy • Treatment of malignant diseases • tumor growth
ISBN-10 3-642-26145-0 / 3642261450
ISBN-13 978-3-642-26145-9 / 9783642261459
Zustand Neuware
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