CD4+CD25+ Regulatory T Cells: Origin, Function and Therapeutic Potential (eBook)

B. Kyewski, Elisabeth Suri-Payer (Herausgeber)

eBook Download: PDF

2006 | 2005
XII, 332 Seiten
Springer Berlin (Verlag)
978-3-540-27702-6 (ISBN)

Infos

The vertebrate immune system defends the organism against invading pathogens while at the same time being self-tolerant to the body's own constituents thus preserving its integrity. Multiple mechanisms act in concert to ensure self-tolerance. Additional tolerance mechanisms, collectively referred to as dominant tolerance is by now firmly established. It will offer new conceptual insights and hopefully new tools for the sucessful treatment of autoimmune diseases, improved cancer immunotherapy and transplant survival.

Inhalt

Preface.- Selection of CD4+CD25+ Regulatory T Cells by Self-Peptides.- The Role of TCR Specificity in Naturally Arising CD25+ CD4+ Regulatory T Cell Biology.- Thymic Commitment of Regulatory T Cells Is a Pathway of TCR-Dependent Selection That 'Isolates' Repertoires Undergoing Positive or Negative Selection.- Selection and Behaviour of CD4+CD25+ T Cells in vivo: Lessons from T Cell Receptor Transgenic Models.- Migration Matters: Functional Properties of Naïve- and Effector/Memory-Like Regulatory T Cell Subsets.- Peripheral Generation and Function of CD4+CD25+ Regulatory T Cells.- Dendritic Cells, Key Cells for the Induction of Regulatory T Cells?.- Autoimmune Gastritis Is a Well-Defined Autoimmune Disease Model for the Study or CD4+CD25+ T Cell-Mediated Suppresion.- Regulatory T Cells in Experimental Colitis.- Autoimmune Ovarian Disease in Day 3-Thymectomized Mice: the Neonatal Time Window, Antigen Specificity of Disease Suppression, and Genetic Control.- Regulatory T Cells in Transplantation Tolerance. Infectious Tolerance.- CD4+CD25+ Regulatory T Cells in Hematopoietic Stem Cell Transplantation.- ……………...- Phenotypic and Functional Differences Between Human CD4+CD25+ and Type 1 Regulatory T Cells.- Subject Index.

Produkt-Details

• Erscheint lt. Verlag: 9.1.2006
• Reihe/Serie: Current Topics in Microbiology and Immunology
• Reihe/Serie: Current Topics in Microbiology and Immunology
• Zusatzinfo: XII, 332 p. 18 illus., 12 illus. in color.
• Verlagsort: Berlin
• Sprache: englisch
• Themenwelt: Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
• Schlagworte: Antigen • autoimmune disease • Autoimmune diseases • Cancer • Cancer Immunotherapy • Cell • Cell Biology • Dendritic cells • Diseases • Dominant Tolerance • hematopoietic stem cell transplantation • immune system • immunotherapy • Regulatory Cells • stem cell transplantation • Suppressor T Cells • T Cell • Transplantation • Transplant Survival • Tumor
• ISBN-10: 3-540-27702-1 / 3540277021
• ISBN-13: 978-3-540-27702-6 / 9783540277026