Melanoma Development (eBook)

Molecular Biology, Genetics and Clinical Application

Anja Bosserhoff (Herausgeber)

eBook Download: PDF

2011 | 2011
XI, 376 Seiten
Springer Wien (Verlag)
978-3-7091-0371-5 (ISBN)

Infos

The book provides comprehensive insights into molecular changes in malignant melanoma. The general mechanisms of melanoma growth and development are described, as well as new research findings. Our current knowledge on the molecules involved in cell transformation and tumor progression will soon lead to sophisticated, targeted therapies. Recent studies with targeted b-RAF inhibitors have given us grounds to hope that these therapies will be successful. Melanoma Development- Molecular Biology, Genetics and Clinical Application aims to contribute to this knowledge. Summarizing the newest data and presenting upcoming research areas in the field, the book will be of great interest to basic researchers and physicians working in the important fields of melanoma, cancer research, therapy and dermatology.

Anja Bosserhoff studied biology at the University of Bielefeld, Germany. She completed her PhD at the Department of Dermatology, University of Regensburg, Germany, in 1995. Between 1995 and 1998 she received her postdoctoral education at the Institute for Pathology, University of Regensburg. In 1998 and 1999 she served as assistant researcher at the Institute for Pathology in Regensburg and at the Rhine-Wesfalia-Technical -University (RWTH) in Aachen, Germany, respectively. In 2000 she became Professor in general and molecular pathology of the cell at the University of Aachen (Habilitation). Since 2002 Anja Bosserhoff has been Full Professor at the Institute for Pathology and Head of the Division of Molecular Pathology in Regensburg. She has published more than 150 papers in international renowned high impact journals, contributed to several book projects and written several review articles. She received various national and international research awards, among which the 'Deutscher Hautkrebspreis' in 2007.

Inhalt

1 Overview. 2 Melanocytes. 3 Epidemiology of Melanoma. 4 Melanoma Genetics and Genomics. 5 Transcriptional Regulation in Melanoma. 6 miRNAs in Malignant Melanoma. 7 Cell Signaling. 8 Proteases in Melanoma. 9 Cell-cell and cell-matrix Contacts in Melanoma and the Tumor Microenvironment. 10 Regulation of Apoptosis in Melanoma Cells – Targets for Therapeutic Strategies. 11 Senescence. 12 Melanoma Stem Cells. 13 Lessons from Embryogenesis. 14 The Influence of the Tumor Microenvironment. 15 Melanoma Model Systems. 16 New Therapeutic Approaches in Signalling . 17 New Therapeutic Approaches in Immunology

Produkt-Details

• Erscheint lt. Verlag: 24.6.2011
• Zusatzinfo: XI, 376 p.
• Verlagsort: Vienna
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
• Themenwelt: Medizin / Pharmazie ► Studium
• Schlagworte: melanoma • senescence • skin carcinoma • Stem Cells • tumor microenvironment
• ISBN-10: 3-7091-0371-1 / 3709103711
• ISBN-13: 978-3-7091-0371-5 / 9783709103715