Immunoglobulins (eBook)

Structure and Function

Roald Nezlin (Autor)

eBook Download: PDF

1998 | 1. Auflage
269 Seiten
Elsevier Science (Verlag)
978-0-08-053452-7 (ISBN)

Infos

This book provides comprehensive up-to-date information on the structure and function of immunoglobulins. It describes the basic features of these molecules, which assists the reader in understanding how they function as an integral part of the immune system. The Immunoglobulins describes the localization and structure of different binding sites of immunoglobulin molecules, including the antigen-binding site, on the basis of latest x-ray crystallography studies. It discusses recently developed biotechnological methods that allow scientists to obtain fully active antibody molecules in vitro even without immunization and to construct new variants of immunoglobulins and their fragments by fusing with various other active molecules. A survey of recent knowledge on immunoglobulin-binding molecules other than antigens and on flexibility of immunoglobulin molecules concludes the discussion of functional aspects of the problem.

Key Features
* Describes recent reviews on the structure and function of immunoglobulin molecules of various species
* Summarizes in detail recent findings on the fine structure of the antigen-combining site
* Presents comparative data on the antigen-recognizing sites of other molecules such as MHC proteins and T-cell receptors
* Summarizes growing data on immunoglobulin binding sites responsible for the reaction of immunoglobulins with molecules other than antigens
* Explores the rapid advance of recent biotechnological methods used for the construction of antibody molecules and their fragments with new properties
* Presents extensive references and is lavishly illustrated

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This book provides comprehensive up-to-date information on the structure and function of immunoglobulins. It describes the basic features of these molecules, which assists the reader in understanding how they function as an integral part of the immune system. The Immunoglobulins describes the localization and structure of different binding sites of immunoglobulin molecules, including the antigen-binding site, on the basis of latest x-ray crystallography studies. It discusses recently developed biotechnological methods that allow scientists to obtain fully active antibody molecules in vitro even without immunization and to construct new variants of immunoglobulins and their fragments by fusing with various other active molecules. A survey of recent knowledge on immunoglobulin-binding molecules other than antigens and on flexibility of immunoglobulin molecules concludes the discussion of functional aspects of the problem. - Describes recent reviews on the structure and function of immunoglobulin molecules of various species- Summarizes in detail recent findings on the fine structure of the antigen-combining site- Presents comparative data on the antigen-recognizing sites of other molecules such as MHC proteins and T-cell receptors- Summarizes growing data on immunoglobulin binding sites responsible for the reaction of immunoglobulins with molecules other than antigens- Explores the rapid advance of recent biotechnological methods used for the construction of antibody molecules and their fragments with new properties- Presents extensive references and is lavishly illustrated

Inhalt

Front Cover 1
The Immunoglobulins: Structure and Function 4
Copyright Page 5
Contents 6
Preface 12
Part I :Structural Aspects 16
Chapter 1. General Characteristics of Immunoglobulin Molecules 18
I. Immunoglobulin Classes 19
II. Heterogeneity of Immunoglobulins 25
III. Detection and Isolation of Immunoglobulins 26
IV. Proteolytic and Chemical Fragments of Immunoglobulins 28
V. Immunoglobulin Peptide Chains 32
VI. Additional Peptide Chains 43
VII. Immunoglobulin Fold (Domain) 51
VIII. Fab Portion 57
IX. Fc Portion 58
X. Immunoglobulin Molecules 58
XI. Carbohydrate Components of Immunoglobulins 67
References 77
Chapter 2. Animal and Human Immunoglobulins 90
I. Low Vertebrates 91
II. Birds 96
III. Mammals 99
IV. Human Immunoglobulins 110
V. Origin of Antibody Diversity in Mice and Humans 115
VI. Evolutionary Aspects 120
References 128
Chapter 3. Engineering Antibody Molecules 138
I. Problems of Serum Immunotherapy 138
II. Chimeric Antibody Molecules and Humanization 140
III. Minimal Antibody Fragment (Fv) 142
IV. Production of Human Monoclonal Antibodies 145
V. Engineering of Immunoglobulins with Novel Properties 149
VI. Polymerization of IgG Molecules and Their Fragments 152
VII. Bispecific Antibodies 154
References 157
Part II: Functional Aspects 164
Chapter 4. Antigen-Combining Site 166
I. General Characteristics 166
II. Conformational Changes Linked with Antigen Binding 184
III. Complex of VH Domain of Camelid Heavy Chain Antibodies with Antigen 188
IV. Interaction of an Autoantibody (Rheumatoid Factor) with Fc? 188
V. Structural Aspects of Antibody Specificity 189
VI. Modeling Antibody-Combining Sites 198
VII. Structural Aspects of Catalytic Antibody Activity 204
References 210
Chapter 5. Antigen-Recognizing Molecules Other Than Antibodies 220
I. T-Cell Antigen Receptor 220
II. Proteins of Major Histocompatibility Complex 222
III. Complexes of T-Cell Receptor and Peptide–MHC 226
IV. CD1 Molecules 227
V. Natural Killer Cell Inhibitory Receptors 228
VI. Comparison of Antigen Binding by Various Antigen-Recognizing Molecules 230
References 231
Chapter 6. Interactions Outside the Antigen-Combining Site 234
I. Fc Receptor-Binding Sites 236
II. Complement-Binding Sites 245
III. Proteins Reacting with the Fc Portion 250
IV. Proteins Reacting with the Fab Portion 252
V. Lectins 254
VI. Molecular Chaperones 256
VII. Bacterial Immunoglobulin-Binding Proteins 258
References 262
Chapter 7. Segmental Movements of Immunoglobulin Molecules 270
I. General Aspects 270
II. Functional Aspects of Segmental Flexibility 274
References 276
Index 278
Color Plates Section 286

Produkt-Details

• Erscheint lt. Verlag: 6.5.1998
• Sprache: englisch
• Themenwelt: Medizinische Fachgebiete ► Innere Medizin ► Hämatologie
• Themenwelt: Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
• Themenwelt: Naturwissenschaften ► Biologie ► Biochemie
• Themenwelt: Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
• Themenwelt: Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
• Themenwelt: Naturwissenschaften ► Physik / Astronomie ► Angewandte Physik
• Themenwelt: Technik
• ISBN-10: 0-08-053452-X / 008053452X
• ISBN-13: 978-0-08-053452-7 / 9780080534527