Photodynamic Therapy and Fluorescence Diagnosis in Dermatology (eBook)

P. Calzavara-Pinton, B. Ortel, R-M. Szeimies (Autoren)

eBook Download: PDF

2001 | 1. Auflage
392 Seiten
Elsevier Science (Verlag)
978-0-08-053884-6 (ISBN)

Infos

Photodynamic therapy has been widely investigated over the past two decades and is emerging as a promising therapeutic modality for skin cancers and several inflammatory diseases. This growing interest is based on the availability of a new simple, effective and safe regimen using the topical application of a pro-drug, 5-aminolevulinic acid, as well as on the development of new second generation photosensitizers, namely 5-aminolevulinic acid-esters, phthalocyanines, chlorins, porphycenes and hypericin. In contrast to hematoporphyrin derivatives, these compounds are characterized by short-lasting generalized skin photosensitivity. These dyes are available for either topical or systemic delivery and are well characterized.
The basic principles of PDT is more complex than chemotherapy or other pharmacological modalities. PDT involves not only a drug but an otherwise harmless compound that is activated by visible light. The interaction of these two treatment components is PDT. The variability of these both components results in a complexity of the treatment that may disorient the clinician who does not have specific experience in this field. This book aims to focus experimental and clinical findings on PDT in order to attract and direct the attention of a growing number of dermatologists.

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Photodynamic therapy has been widely investigated over the past two decades and is emerging as a promising therapeutic modality for skin cancers and several inflammatory diseases. This growing interest is based on the availability of a new simple, effective and safe regimen using the topical application of a pro-drug, 5-aminolevulinic acid, as well as on the development of new "e;second generation"e; photosensitizers, namely 5-aminolevulinic acid-esters, phthalocyanines, chlorins, porphycenes and hypericin. In contrast to hematoporphyrin derivatives, these compounds are characterized by short-lasting generalized skin photosensitivity. These dyes are available for either topical or systemic delivery and are well characterized. The basic principles of PDT is more complex than chemotherapy or other pharmacological modalities. PDT involves not only a drug but an otherwise harmless compound that is activated by visible light. The interaction of these two treatment components is PDT. The variability of these both components results in a complexity of the treatment that may disorient the clinician who does not have specific experience in this field. This book aims to focus experimental and clinical findings on PDT in order to attract and direct the attention of a growing number of dermatologists.

Inhalt

Front Cover 1
PHOTODYNAMIC THERAPY AND FLUORESCENCE DIAGNOSIS IN DERMATOLOGY 4
Copyright Page 5
TABLE OF CONTENTS 16
Part I: History and Basics 20
Chapter 1. History of photodynamic therapy in dermatology 22
Chapter 2. Primary processes in photosensitization mechanisms 36
Chapter 3. Mechanism of action- molecular effects 58
Chapter 4. Correlation of intracellular and intratumoral photosensitizer distribution with photodynamic effect 74
Chapter 5. Immunologic actions of PDT 86
Chapter 6. Light sources for photodynamic therapy and fluorescence diagnosis in dermatology 102
Part II: Photosensitizers 118
Chapter 7. Photosensitizers - systemic sensitization 120
Chapter 8. Basic principles of 5-aminolevulinic acid-based photodynamic therapy 134
Part III: Fluorescence Diagnosis 182
Chapter 9. Fluorescence diagnosis 184
Part IV: Systemic Photodynamic Therapy 194
Chapter 10. Systemic sensitization - oncologic indications in dermatology 196
Chapter 11. Systemic sensitization - non-oncologic indications in dermatology 206
Part V: Topical Photodynamic Therapy 216
Chapter 12. Topical sensitization - oncologic indications - actinic keratoses 218
Chapter 13. Topical sensitization - oncologic indications - Bowen's disease 236
Chapter 14. Photodynamic therapy of basal cell carcinoma 254
Chapter 15. Topical sensitization - oncologic indications - others (lymphoma) 268
Chapter 16. Topical photodynamic therapy for psoriasis 278
Chapter 17. Photodynamic therapy of pilosebaceous units 290
Chapter 18. Topical sensitization - non-oncologic indications - HPV-infections 302
Chapter 19. Topical sensitization - non-oncologic indications - others (scleroderma, sarcoidosis, eczema) 320
Part VI: Concluding Remarks 326
Chapter 20. Practical guidelines 328
Chapter 21. Cutaneous photosensitivity and photoprotection for photodynamic therapy patients 340
Chapter 22. Future directions - photosensitizer targeting and new disease indications 358
KEYWORD INDEX 386

Produkt-Details

• Erscheint lt. Verlag: 13.8.2001
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Dermatologie
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
• Themenwelt: Naturwissenschaften ► Biologie ► Biochemie
• Themenwelt: Naturwissenschaften ► Chemie ► Organische Chemie
• Themenwelt: Naturwissenschaften ► Chemie ► Physikalische Chemie
• Themenwelt: Naturwissenschaften ► Physik / Astronomie ► Angewandte Physik
• Themenwelt: Naturwissenschaften ► Physik / Astronomie ► Optik
• Themenwelt: Technik
• ISBN-10: 0-08-053884-3 / 0080538843
• ISBN-13: 978-0-08-053884-6 / 9780080538846