Membranes and Cell Signaling (eBook)

Edward Bittar (Herausgeber)

eBook Download: PDF

1997 | 1. Auflage
637 Seiten
Elsevier Science (Verlag)
978-0-08-053611-8 (ISBN)

Infos

It should not come as too much of a surprise that biological membranes are considerably more complex than lipid bilayers. This has been made quite clear by the fluid-mosaic model which considers the cell membrane as a two-dimensional solution of a mosaic of integral membrane proteins and glycoproteins firmly embedded in a fluid lipid bilayer matrix. Such a model has several virtues, chief among which is that it allows membrane components to diffuse in the plane of the membrane and orient asymmetrically across the membrane. The model is also remarkable since it provokes the right sort of questions. Two such examples are: Does membrane fluidity influence enzyme activity? Does cholesterol regulate fluidity? However, it does not go far enough. As it turns out, there is now another version of this model, the so-called post-fluid mosaic model which incorporates two concepts, namely the existence in the membrane of discrete domains in which specific lipid-lipid, lipid-protein and protein-protein interactions occur and ordered regions that are in motion but remain separate from less ordered regions. We must admit that both are intriguing problems and of importance in guiding our thinking as to what the next model might be.
We have chosen not to include the subject of membrane transport in the present volume. This obviously represents a break with convention. However, the intention is to have the topic covered subsequent volumes relating to organ systems. It would be right to regard this as an attempt to strengthen the integrated approach to the teaching of medicine.

Inhalt

Cover 1
Contents 8
List of Contributors 12
Preface 18
Chapter 1. Model Membrane Systems 20
Chapter 2. Lipid-Bilayer Heterogeneity 38
Chapter 3. Lipid-Protein Interactions in Biological Membranes 58
Chapter 4. Lipid Modifications of Proteins and its Relevance to Protein Targeting 86
Chapter 5. The Influence of Dietary Fat on Membranes 112
Chapter 6. Membrane Fusion and Exocytosis 140
Chapter 7. Endocytosis 162
Chapter 8. Signal Peptides 190
Chapter 9. Proteolysis in Protein Import and Export 204
Chapter 10. Membrane Traffic and Sorting 224
Chapter 11. Molecular Genetics and Evolution of Voltage Gated Channels 248
Chapter 12. Molecular Biology of Voltage-Gated Ionic Channels: Structure Function Relationships 264
Chapter 13. Ligand-Gated lon Channels in Vertebrates 326
Chapter 14. Mechano-Sensitive Channels 360
Chapter 15. Patch Clamping Methods and Analysis of Ion Channels 374
Chapter 16. Functional Expression of Ionic Channels and Membrane Transporters in Xenopus Oocytes 396
Chapter 17. The Plasma Membrane as A Transducer and Amplifier 406
Chapter 18. G-Protein Coupled Receptors and Hormone Secretion 440
Chapter 19. The Role of ras in Signal Transduction 470
Chapter 20. The Polyphosphoinositide Signaling System 488
Chapter 21. Other Lipids as Second Messengers 506
Chapter 22. The Role of Intracellular Calcium as a Regulatory System 534
Chapter 23. The Role of Guanylyl Cyclases as Signal Transducing Enzymes 550
Chapter 24. Stimulus-Response Coupling in Secretory Cells 560
Chapter 25. Cell Interactions with Extracellular Matrices 592
Chapter 26. Intercellular Communication 628
Index 648

Produkt-Details

• Erscheint lt. Verlag: 12.5.1997
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Studium ► 1. Studienabschnitt (Vorklinik)
• Themenwelt: Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
• Themenwelt: Naturwissenschaften ► Biologie ► Humanbiologie
• Themenwelt: Naturwissenschaften ► Biologie ► Zellbiologie
• Themenwelt: Technik ► Umwelttechnik / Biotechnologie
• ISBN-10: 0-08-053611-5 / 0080536115
• ISBN-13: 978-0-08-053611-8 / 9780080536118