Advances in Clinical Chemistry (eBook)

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2009 | 1. Auflage
200 Seiten
Elsevier Science (Verlag)
978-0-08-095100-3 (ISBN)

Infos

Volume 49 in the internationally acclaimed Advances in Clinical Chemistry contains chapters submitted from leading experts from academia and clinical laboratory science. Authors are from a diverse field of clinical chemistry disciplines and diagnostics ranging from basic biochemical exploration to cutting-edge microarray technology. - Leading experts from academia and clinical laboratory science - Volume emphasizes novel laboratory advances with application to clinical laboratory diagnostics and practical basic science studies

Inhalt

Front Cover 1
Advances in Clinical Chemistry 4
Copyright Page 5
Contents 6
Contributors 10
Preface 12
Chapter 1: High-Sensitivity Troponin: A New Tool for Pathophysiological Investigation and Clinical Practice 14
2. Background and Aim 15
3. Introduction: Troponin Framework Within Myocardial Cells and Release Kinetics After Myocardial Damage 17
4. Impact of the New Definition of Myocardial Infarction on Laboratory Practice and Instrumentation: The Need for High-Sensitivity cTnI and cTnT Methods 18
5. The Impact of High-Sensitivity cTnI and cTnT Methods on Clinical Practice 22
6. High-Sensitivity cTnI and cTnT Methods: A Powerful Tool for Monitoring Physiological Renewal and Pathological Remodeling of the Myocardial Tissue? 32
7. Use of High-Sensitivity cTnI and cTnT Methods in a Multimarker Approach for Early Screening: An Increase in Diagnostic and Prognostic Efficiency? 35
8. Conclusion 36
References 37
Chapter 2: Biochemical Biomarkers of Oxidative Collagen Damage 44
2. The Collagen Family: Structure and Biochemistry 45
3. Chemical Nature and Reactivity of Oxygen 46
4. In Vivo Production of RNOS 48
5. RNOS Biological Activity 50
6. In Vivo Markers of Oxidant Stress 52
7. Oxidant-Induced Changes in Collagens 53
8. Biomarkers of Collagen Oxidative Damage 56
9. Critical Comments and Concluding Remarks 61
References 62
Chapter 3: Biochemical Basis of Fabry Disease with Emphasis on Mitochondrial Function and Protein Trafficking 70
2. Introduction 71
3. Inheritance 71
4. Clinical Picture 72
5. Diagnosis 72
6. Treatment 73
7. Biochemical Basis 75
References 81
Chapter 4: Urinary Biomarkers for the Detection of Renal Injury 86
2. Introduction 87
3. Biomarker Development for Kidney Diseases 88
4. Biomarkers for AKI 94
5. Biomarker Development and Implementation 103
6. Summary 104
References 105
Chapter 5: Biomarkers of Bone and Mineral Metabolism Following Bone Marrow Transplantation 112
2. Introduction 113
3. Clinical Features of BMT-Related Bone Loss 113
4. Changes in Bone-Turnover Markers After BMT 115
5. Calcium, Parathyroid Hormone (PTH), and Vitamin D 122
6. Sex Hormones 123
7. RANKL and Osteoprotegerin 125
8. Cytokines and Growth Factors 127
9. Conclusion 128
References 129
Chapter 6: Factor V Leiden and Activated Protein C Resistance 134
2. Introduction 135
3. The Protein C System 136
4. APC Resistance and FV Leiden 143
5. Conclusions and Perspectives 156
Acknowlegement 157
References 157
Chapter 7: Self-Assembled Tethered Bimolecular Lipid Membranes 172
2. Introduction 173
3. Assembly of tBLMs from Telechelics and Reconstitution of Proteins 175
4. The Peptide-Tethered Lipid Bilayer Membrane (peptBLM) 178
5. Protein-Tethered Bilayer Lipid Membrane (protBLM) 183
6. Conclusions 187
Acknowledgments 190
References 190
Index 194
Color Plates 200

Produkt-Details

• Erscheint lt. Verlag: 3.11.2009
• Mitarbeit: Herausgeber (Serie): Gregory S. Makowski
• Sprache: englisch
• Themenwelt: Sachbuch/Ratgeber
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete
• Themenwelt: Studium ► 2. Studienabschnitt (Klinik) ► Anamnese / Körperliche Untersuchung
• Themenwelt: Naturwissenschaften ► Biologie ► Biochemie
• Themenwelt: Naturwissenschaften ► Chemie
• Themenwelt: Naturwissenschaften ► Physik / Astronomie ► Angewandte Physik
• Themenwelt: Technik
• ISBN-10: 0-08-095100-7 / 0080951007
• ISBN-13: 978-0-08-095100-3 / 9780080951003