Autoimmune Diseases (eBook)

M. Eric Gershwin, George C. Tsokos (Herausgeber)

eBook Download: EPUB

2006 | 4. Auflage
1160 Seiten
Elsevier Science (Verlag)
978-0-08-045474-0 (ISBN)

Infos

Since publication of the Third Edition in 1998, the understanding of the immune mechanisms underlying autoimmunity and autoimmune disease has significantly deepened and broadened. This Fourth Edition incorporates new material and combines common themes underlying inductive and effector mechanisms and therapies that relate generally to the autoimmune disorders. It discusses the biological basis of disease at genetic, molecular, cellular, and epidemiologic levels.New to This Edition:* Tissue-specific interventions to arrest or 'cure' autoimmune disease* Bone marrow eradication and replacement* Both basic science and clinical medicine is covered* Boxed points to emphasize key features of each chapter

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Since publication of the Third Edition in 1998, the understanding of the immune mechanisms underlying autoimmunity and autoimmune disease has significantly deepened and broadened. This Fourth Edition incorporates new material and combines common themes underlying inductive and effector mechanisms and therapies that relate generally to the autoimmune disorders. It discusses the biological basis of disease at genetic, molecular, cellular, and epidemiologic levels.New to This Edition:* Tissue-specific interventions to arrest or "e;cure"e; autoimmune disease* Bone marrow eradication and replacement* Both basic science and clinical medicine is covered* Boxed points to emphasize key features of each chapter

Inhalt

front cover 1
copyright 5
table of contents 6
front matter 11
Editorial Advisory Board 11
Contributors 12
Reviewers 16
Acknowledgments 18
Prospectus: The Road to Autoimmune Disease 20
body 28
Section I Immunologic Basis of Autoimmunity 28
1: Autoimmunity: A History of the Early Struggle for Recognition 30
2: Structural and Functional Aspects of the Innate and Adaptive Systems of Immunity 38
3: General Features of Autoimmune Disease 52
4: Antigen Presentation, Dendritic Cells, and Autoimmunity 64
5: Major Histocompatibility Complex and Autoimmunity 74
6: T Cells and Autoimmunity 86
7: Role of Th1 and Th2 Cells in Autoimmunity 110
8: Tolerance and Autoimmunity: T Cells 130
9: Regulatory T Cells 146
10: Peptide-Based Instruction of Suppressor Commitment in Naïve T Cells 160
11: B Cells and Autoimmunity 166
12: Memory B-Cell Development 184
13: Tolerance and Autoimmunity: B Cells 194
14: Generation of T-cell Antigenic Determinants in Autoimmunity and Their Recognition 206
15: Apoptotic Cells as a Source of Autoantigens 220
16: Effector Mechanisms of Autoimmunity: Antibodies and Immune Complexes 230
17: Functional Effects of Autoantibodies 244
18: Adhesion Molecules and Chemoattractants in the Pathogenesis and Treatment of Autoimmune Diseases 264
19: Signaling Pathways in T and B Lymphocytes 276
20: Genetics and Autoimmunity: HLA and MHC Genes 288
21: Genetics and Autoimmunity: Non-MHC Genes 300
22: Infections, Immunity, and Autoimmunity 316
23: Noninfectious Environmental Agents and Autoimmunity 324
24: Vaccines and Autoimmunity 336
25: Sex, Pregnancy, and Autoimmunity 344
26: Animal Models of Autoimmune Disease 356
Section II Autoimmune Diseases - Multisystem Diseases 376
71: Cameos 1022
70: Apoptosis and Autoimmunity: Lymphoproliferative Syndromes 1014
69: Lymphoma and Autoimmune Disease 998
68: Paraneoplastic Neurologic Diseases: Autoimmune Responses to Tumor Antigens 984
67: Idiopathic Bronchiolitis Obliterans, Idiopathic Pulmonary Fibrosis, and Autoimmune Disorders of the Lung 962
66: Large and Medium Vessel Vasculitides 948
65: Necrotizing Arteritis and Small Vessel Vasculitis 926
64: Atherosclerosis: Autoimmunity to Heat-Shock Proteins 916
63: Myocarditis and Dilated Cardiomyopathy 902
62: Rheumatic Heart Disease 890
61: Oophoritis 876
60: Orchitis and Male Infertility 868
59: Kidney Disease: Goodpasture’s Disease, Lupus Nephritis, ANCA-Associated Glomerulonephritis 848
58: Non-Bullous Skin Diseases: Alopecia, Vitiligo Psoriasis, and Urticaria 834
57: Bullous Skin Diseases: Pemphigus Pemphigoid 816
56: Pancreatitis 806
55: Primary Sclerosing Cholangitis 794
54: Primary Biliary Cirrhosis 776
53: Chronic Hepatitis 756
52: Inflammatory Bowel Diseases: Ulcerative Colitis and Crohn’s Disease 740
51: Celiac Disease 720
50: Inner Ear Disease 708
49: Ocular Disease 696
48: Myasthenia Gravis and other Antibody-Associated Neurological Diseases 680
47: Peripheral Neuropathy 660
46: Multiple Sclerosis 642
45: Clotting Disorders 628
44: Aplastic Anemia 618
43: Neutropenia 612
42: Thrombocytopenic Purpura 602
41: Hemolytic Anemia 584
40: Hypophysitis 574
39: Gastritis and Pernicious Anemia 554
38: Polyendocrine Syndromes 542
37: Adrenalitis 528
36: Type 1 Diabetes 510
35: Thyroid Disease 494
34: Polymyositis and Dermatomyositis 480
33: Spondyloarthritis and Chronic Idiopathic Arthropathies 464
32: Rheumatoid Arthritis 444
31: Sjögren Syndrome 428
30: Antiphospholipid Syndrome 408
29: Systemic Sclerosis, Scleroderma 396
28: Systemic Lupus Erythematosus: Immunologic Features 384
27: Systemic Lupus Erythematosus and Related Diseases: Clinical Features 378
Section III Diagnosis, Prevention, and Therapy 1036
72: Autoantibody Assays, Testing, and Standardization 1038
73: T Cell Assays 1050
74: Prediction of Autoimmune Disease 1058
75: Prevention of Autoimmune Disease: Type 1 Diabetes as a Paradigm 1072
76: Emerging Therapies for Autoimmune Diseases 1090
Section IV Epilogue 1110
77: Advocatus Diaboli: What is not known about Autoimmune Disease 1112
index 1122

Produkt-Details

• Erscheint lt. Verlag: 15.5.2006
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Allgemeines / Lexika
• Themenwelt: Medizinische Fachgebiete ► Innere Medizin ► Rheumatologie
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Urologie
• Themenwelt: Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
• ISBN-10: 0-08-045474-7 / 0080454747
• ISBN-13: 978-0-08-045474-0 / 9780080454740