Advances in Molecular and Cellular Endocrinology (eBook)

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1997 | 1. Auflage
269 Seiten
Elsevier Science (Verlag)
978-0-08-052638-6 (ISBN)

Historically the field of endocrine research has always been at the forefront of scientific endeavors. The investigators of these important breakthroughs in research have been rewarded by numerous Nobel awards. In the field of diabetes alone, Nobel prizes have been awarded to researchers who discovered insulin, characterized the protein and invented radioimmunoassays using insulin as a paradigm. Not surprisingly, biomedical researchers have always been attracted by the endocrine system and other similar systems of intercellular communication.
Over the past two decades, endocrine research has developed rapidly and adapted modern molecular and cellular biology techniques for its specific use. These changes have allowed researchers in the field to maintain their edge. Thus, endocrine disease-related genes have been characterized and mutations in these genes have helped explain common and
less common endocrine disorders. Our understanding of the regulation of gene expression has been greatly enhanced by molecular techniques.
In an attempt to bring investigators up to date with the recent advances in this exploding field we have decided to publish a series entitled Advances in Molecular and Cellular Endocrinology. Internationally famous investigators have agreed to participate and their contributions are appreciated.
Volume 1 has focused on aspects of the hypothalamic-pituitary axis including GnRH and GH gene regulation, molecular aspects of insulin, insulin-like growth factors and glucagon. In addition, reviews on the recently cloned calcium receptor and steroid receptor interactions with DNA are presented.

Historically the field of endocrine research has always been at the forefront of scientific endeavors. The investigators of these important breakthroughs in research have been rewarded by numerous Nobel awards. In the field of diabetes alone, Nobel prizes have been awarded to researchers who discovered insulin, characterized the protein and invented radioimmunoassays using insulin as a paradigm. Not surprisingly, biomedical researchers have always been attracted by the endocrine system and other similar systems of intercellular communication.Over the past two decades, endocrine research has developed rapidly and adapted modern molecular and cellular biology techniques for its specific use. These changes have allowed researchers in the field to maintain their edge. Thus, endocrine disease-related genes have been characterized and mutations in these genes have helped explain common and less common endocrine disorders. Our understanding of the regulation of gene expression has been greatly enhanced by molecular techniques. In an attempt to bring investigators up to date with the recent advances in this exploding field we have decided to publish a series entitled Advances in Molecular and Cellular Endocrinology. Internationally famous investigators have agreed to participate and their contributions are appreciated. Volume 1 has focused on aspects of the hypothalamic-pituitary axis including GnRH and GH gene regulation, molecular aspects of insulin, insulin-like growth factors and glucagon. In addition, reviews on the recently cloned calcium receptor and steroid receptor interactions with DNA are presented.

Cover 1
Copyright Page 5
Contents 6
List of Contributors 8
Preface 12
Chapter 1. Molecular Aspects of GnRH Gene Expression 14
Chapter 2. Molecular Aspects of Hormone Deficiency Caused By PIT-1 Gene Mutations 44
Chapter 3. Regulation of Growth Hormone Gene 64
Chapter 4. Molecular Aspects of the Insulin-Like Growth Factor (IGF) Genes 96
Chapter 5. Molecular Aspects of Insulin-Like Growth Factor Binding Proteins 136
Chapter 6. Molecular Basis of Insulin Action 174
Chapter 7. Molecular Aspects of the Glucagon Gene 216
Chapter 8. Molecular Aspects of Familial Hypocalciuric Hypercalcemia 242
Chapter 9. Molecular Aspects of Steroid Receptor/Dna Binding 254
Index 278

Erscheint lt. Verlag	25.3.1997
Sprache	englisch
Themenwelt	Medizinische Fachgebiete ► Innere Medizin ► Endokrinologie
	Medizinische Fachgebiete ► Innere Medizin ► Kardiologie / Angiologie
	Studium ► 1. Studienabschnitt (Vorklinik) ► Biochemie / Molekularbiologie
	Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
	Naturwissenschaften ► Biologie ► Zoologie
	Technik
ISBN-10	0-08-052638-1 / 0080526381
ISBN-13	978-0-08-052638-6 / 9780080526386

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