Advances in Clinical Chemistry (eBook)

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2010 | 1. Auflage
232 Seiten
Elsevier Science (Verlag)
978-0-12-380982-7 (ISBN)

Infos

Volume 47 in the internationally acclaimed Advances in Clinical Chemistry contains chapters submitted from leading experts from academia and clinical laboratory science. Authors are from a diverse field of clinical chemistry disciplines and diagnostics, ranging from basic biochemical exploration to cutting-edge microarray technology. - Leading experts from academia and clinical laboratory science - Volume emphasizes novel laboratory advances with application to clinical laboratory diagnostics and practical basic science studies

Inhalt

Front Cover 1
Advances in Clinical Chemistry 4
Copyright Page 5
Contents 6
Contributors 10
Preface 12
Chapter 1: Prothrombin Fragments in Cardiovascular Disease 14
1. Abstract 14
2. Introduction: Thrombosis and Cardiovascular Disease 15
3. The Blood Coagulation 16
4. Markers of Hemostatic Activation 18
5. F1+2 in Cardiovascular Disease 19
6. How Can Circulating Levels of F1+2 Be Modulated? 29
7. Pathophysiological Aspects of Other Prothrombin Fragments 29
8. Conclusions 29
Acknowledgments 30
References 30
Chapter 2: Carbamylated LDL 38
1. Abstract 39
2. Atherosclerosis in Kidney Disease 39
3. Chronic Uremia-Induced Atherosclerosis 39
4. Modified LDLs in Atherosclerosis 41
5. Uremic Toxins and Protein Carbamylation 42
6. Plasma Protein Carbamylation and Atherosclerosis 44
7. LDL Carbamylation: Initial Observations 44
8. Induction of Proliferation and Death of Cultured Endothelial Cells by cLDL 45
9. Acceleration of Monocyte Adhesion to Endothelial Cells by cLDL 45
10. Endothelial cLDL Receptors 46
11. Effects of cLDL on Cultured Smooth-Muscle Cells 48
12. In Vivo Properties of cLDL 48
13. cLDL Assays 49
14. Human Studies of cLDL 49
15. Autoantibody to cLDL and Other Modified LDLs 53
16. Double Modified LDLs 53
17. Perspectives of Anti-cLDL Therapy 54
18. Conclusion 55
References 55
Chapter 3: Cocaine in Acute Myocardial Infarction 66
1. Abstract 66
2. Structure and Metabolism of Cocaine 67
3. Epidemiology of Cocaine Abuse 68
4. Cocaine Testing 69
5. Toxicity of Cocaine Abuse 72
6. Cocaine and Chest Pain 73
7. Should Cocaine Use Be Screened in Patients with Acute Myocardial Infarctions? 76
8. Conclusions 80
References 80
Chapter 4: EGFR and KRAS in Colorectal Cancer 84
1. Abstract 85
2. Introduction 85
3. EGFR Signal Transduction 86
4. Monoclonal Antibodies Targeting EGFR 88
5. Landmark Clinical Trials in the Pre-KRAS Era 90
6. Predictive Value of EGFR 92
7. Biology of RAS 92
8. Prognostic Relevance of KRAS Mutations in Colorectal Cancer 94
9. Predictive Role of KRAS Status in Colorectal Cancer 95
10. Testing for KRAS Status 105
11. BRAF in Colorectal Cancer 108
12. Predictive Role of BRAF in Colorectal Cancer 109
13. Alternate Predictive Biomarkers for anti-EGFR Therapies in Colorectal Cancer 111
14. Future Therapeutic Strategies in Colorectal Cancer 119
15. Conclusion 124
References 125
Chapter 5: Prostaglandin EP Receptors and Their Roles in Mucosal Protection and Ulcer Healing in The Gastrointestinal Tract 134
1. Abstract 134
2. Introduction 135
3. Gastric Protection 136
4. Esophageal Protection 143
5. Duodenal Protection and HCO3- Stimulation 144
6. Intestinal Protection 147
7. Healing-Promoting Action 150
8. Summary and Future Prospects 151
Acknowledgments 154
References 154
Chapter 6: Advances in Pancreatic Cancer Detection 158
1. Abstract 158
2. Introduction 159
3. Conventional Markers 160
4. Candidates in Biomarker Discovery 161
5. Therapy-Related Biomarkers 172
6. Genomics/Transcriptomics/Proteomics 173
7. Conclusions 180
Acknowledgments 181
References 181
Chapter 7: Urine Peptidomics for Clinical Biomarker Discovery 194
1. Abstract 194
2. Introduction 195
3. Urine Peptidome is a Rich Source of Peptides of Diversified Protein Origins 195
4. Quantitative Urine Peptidomics for Biomarker Discovery 201
5. Urine Sample Handling and Storage 206
6. Do ``Housekeeping Peptides´´ Exist in Urine Peptidome? 211
7. To Pool or Not Pool, Practical Considerations of Benefits, Risks and Biases 213
8. Multiple Hypothesis Testing, False Discovery, and Bootstrapping Analysis 216
9. Exploration of Urine Peptide Biomarkers as Predictors of Drug Response 219
10. Urine Peptidome Proteolytic Degradation Patterns Reflecting Pathophysiology 221
Acknowledgments 223
References 223
Subject Index 228

Produkt-Details

• Erscheint lt. Verlag: 14.10.2010
• Mitarbeit: Herausgeber (Serie): Gregory S. Makowski
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Laboratoriumsmedizin
• Themenwelt: Studium ► 2. Studienabschnitt (Klinik) ► Anamnese / Körperliche Untersuchung
• Themenwelt: Naturwissenschaften ► Biologie ► Biochemie
• Themenwelt: Naturwissenschaften ► Chemie
• Themenwelt: Naturwissenschaften ► Physik / Astronomie ► Angewandte Physik
• Themenwelt: Technik
• ISBN-10: 0-12-380982-7 / 0123809827
• ISBN-13: 978-0-12-380982-7 / 9780123809827