Advances in Clinical Chemistry (eBook)

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2011 | 1. Auflage
200 Seiten
Elsevier Science (Verlag)
978-0-12-385856-6 (ISBN)

Infos

Volume 53 in the internationally acclaimed Advances in Clinical Chemistry contains chapters submitted from leading experts from academia and clinical laboratory science. Authors are from a diverse field of clinical chemistry disciplines and diagnostics, ranging from basic biochemical exploration to cutting-edge microarray technology.

• Leading experts from academia and clinical laboratory science
• Volume emphasizes novel laboratory advances with application to clinical laboratory diagnostics and practical basic science studies

Inhalt

Front Cover 1
Advances in Clinical Chemistry 4
Copyright Page 5
Contents 6
Contributors 10
Preface 14
Chapter 1: Use of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry for multiplex genotyping 16
2. Introduction 17
3. Genotyping Using Mass Spectrometry 18
4. MALDI-TOF-MS 18
5. Multiplex Genotyping by MALDI-TOF-MS 23
6. Conclusions 34
References 35
Chapter 2: Rheumatic heart disease: Mediation by complex immune events 46
2. Rheumatic Heart Disease 47
3. Epidemiology 47
4. Genetic Susceptibility 47
5. Immune Mechanisms Involved in RHD 54
6. Rheumatic Heart Disease Lesions 57
7. Conclusions 61
Acknowledgments 62
References 62
Chapter 3: Dipeptidyl peptidase in autoimmune pathophysiology 66
2. Introduction 67
3. Molecular Aspects of CD26/DPPIV Role in Immunity 68
4. Cellular Aspects of CD26/DPPIV Role in Immunity 75
5. Clinical Aspects of CD26 Role in Immune Disorders 78
6. Summary and Perspective 86
Acknowledgments 86
References 87
Chapter 4: Biochemistry of HELLP Syndrome 100
2. Introduction 101
3. Pathogenesis of HELLP and Preeclampsia: The Role of Placenta 104
4. Inflammatory Response in HELLP Syndrome 107
5. HELLP Syndrome, Complement Pathway, and the Coagulation System 110
6. Conclusion 113
References 113
Chapter 5: Homocysteine in Pregnancy 120
2. Introduction 121
3. Homocysteine Metabolism 121
4. Prophylactic Folic Acid, Folate Status, and Homocysteine 123
5. Choline and Homocysteine 124
6. Nonnutritional Factors Associated with tHcy 125
7. Health Benefits of tHcy Lowering 125
8. Pregnancy 126
Acknowledgments 144
References 144
Chapter 6: Diabetes and tuberculosis: Analysis of a Paradox 154
2. Introduction 155
3. Definition of the Problem 155
4. Analysis of Previous Experimental Results to Solve the Paradox 157
5. Probable Difference in Glycation Patterns of Macrophage Proteins and Its Precursors 157
6. In Silico Analysis of the Possibility of Glycation-Induced Inhibition of NADPH Oxidase 158
7. Solving the Paradox 161
Acknowledgment 165
References 165
Chapter 7: EGCG, green tea polyphenols and their synthetic analogs and prodrugs for human cancer prevention and treatment 170
2. Introduction 1
3. The Role of Tea Polyphenols in Carcinogenesis 172
4. In Vitro and In Vivo Preclinical Studies on Tea Polyphenols 173
5. Tea Polyphenols and Their Molecular Targets in Cancer Cells 177
6. Tea Polyphenol Derivatives in Cancer Studies 181
7. Conclusions 184
Acknowledgments 185
References 185
Index 194

Produkt-Details

• Erscheint lt. Verlag: 10.3.2011
• Mitarbeit: Herausgeber (Serie): Gregory S. Makowski
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Laboratoriumsmedizin
• Themenwelt: Studium ► 2. Studienabschnitt (Klinik) ► Anamnese / Körperliche Untersuchung
• Themenwelt: Naturwissenschaften ► Biologie ► Biochemie
• Themenwelt: Naturwissenschaften ► Chemie
• Themenwelt: Naturwissenschaften ► Physik / Astronomie ► Angewandte Physik
• Themenwelt: Technik
• ISBN-10: 0-12-385856-9 / 0123858569
• ISBN-13: 978-0-12-385856-6 / 9780123858566