Lymphocyte Signal Transduction (eBook)

Constantine Tsoukas (Herausgeber)

eBook Download: PDF

2007 | 2006
XVII, 302 Seiten
Springer US (Verlag)
978-0-387-34132-3 (ISBN)

Infos

This is the third workshop on this topic that took place in Crete from May 27 to June 1, 2005. Similar to the two previous workshops, held in Santorini October 2000 and 2002 respectively, the purpose of this workshop is to bring together scientists from all over the world to discuss their latest findings on the various aspects of lymphocyte signal transduction. The participants represented academia, industry, foundation and governmental laboratories.

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Signal transduction through leukocyte receptors involves a variety of signaling molecules including kinases, phosphatases, adaptor proteins, small GTPases GTP exchange factors, membrane phospholipids as well as others. These signal transducers, regulated by inter- and intra-molecular interactions, as well as by various post-translational modifications, lead to the activation of transcription factors that mediate cellular differentiation and growth, effector cell functions, and apoptotic cell death. Several investigators from various parts of the world convened at the 3rd Lymphocyte Signal Transduction Workshop in Crete, Greece from May 27 to June 1, 2005 to discuss their most recent findings in leukocyte signaling. This volume represents a collection of topics discussed during the conference.

Inhalt

Foreword 6
Acknowledgments 9
Contents 10
List of Contributors 12
PROTEIN KINASE C-THETA (PKC.): NEW PERSPECTIVES ON ITS FUNCTIONS IN TCELL BIOLOGY 17
TRAVEL INFORMATIONS ON THE TEC KINASES DURING LYMPHOCYTE ACTIVATION 30
INDUCIBLETCELL TYROSINE KINASE (ITK): STRUCTURAL REQUIREMENTS AND ACTIN POLYMERIZATION 43
DIFFERENTIAL REQUIREMENTS OF PI3K SUBUNITS FOR BCR OR BCR/CD19-INDUCED ERK ACTIVATION 56
PROTEIN TYROSINE PHOSPHATASES IN HUMAN DISEASE 66
THE TCELL-SPECIFIC ADAPTER PROTEIN FUNCTIONS AS A REGULATOR OF PERIPHERAL BUT NOT CENTRAL IMMUNOLOGICAL TOLERANCE 86
PROXIMAL SIGNALS CONTROLLING B-CELL ANTIGEN RECEPTOR (BCR) MEDIATED NF-.B ACTIVATION 101
THE ADAPTER 3BP2: HOW IT PLUGS INTO LEUKOCYTE SIGNALING 119
CTLA-4 REGULATION OF TCELL FUNCTION VIA RAP-1-MEDIATED ADHESION 127
PROTEIN CROSSTALK IN LIPID RAFTS 139
ROLE OF LIPID RAFTS IN ACTIVATION INDUCED CELL DEATH : THE FAS PATHWAY IN AGING 149
T CELL RESPONSE IN AGING: INFLUENCE OF CELLULAR CHOLESTEROL MODULATION 168
LYMPHOCYTE SIGNALING AND THE TRANSLATABILITY OF MRNA 181
PROTEIN ARGININE METHYLATION: A NEW FRONTIER IN T CELL SIGNAL TRANSDUCTION 199
IMMUNE REGULATION BY UBIQUITIN CONJUGATION 217
CTIB (C-TERMINUS PROTEIN OF I.B-ß): A NOVEL FACTOR REQUIRED FOR ACIDIC ADAPTATION 228
HIV MAY DEPLETEMOST CD4 LYMPHOCYTES BY A MECHANISM INVOLVING SIGNALING THROUGH ITS RECEPTORS ON NON-PERMISSIVE RESTING LYMPHOCYTES 238
INTEGRATING TRADITIONAL AND POSTGENOMIC APPROACHES TO INVESTIGATE LYMPHOCYTE DEVELOPMENT AND FUNCTION 253
PHOSPHOPROTEOMIC ANALYSIS OF LYMPHOCYTE SIGNALING 285
Author Index 297
Index 298

Produkt-Details

• Erscheint lt. Verlag: 16.1.2007
• Zusatzinfo: XVII, 302 p.
• Verlagsort: New York
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Allgemeines / Lexika
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete
• Themenwelt: Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
• Themenwelt: Naturwissenschaften ► Biologie
• Themenwelt: Technik
• Schlagworte: Antigen • Cell • Cell Biology • HIV • Infectious Diseases • Lymphocytes • Polymer • Protein • proteins • T Cell
• ISBN-10: 0-387-34132-3 / 0387341323
• ISBN-13: 978-0-387-34132-3 / 9780387341323