Tumor Immunology and Cancer Vaccines (eBook)

Samir Khleif (Herausgeber)

eBook Download: PDF

2007 | 2005
X, 398 Seiten
Springer US (Verlag)
978-0-387-27545-1 (ISBN)

Infos

- Volume is divided into four sections, allowing easy navagation for researchers and practicing physicians

- Text includes clinical trials

- Written by leaders in the field

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It all started with an observation. Edward Jenner, an English physician, observed that milkmaids who contracted cowpox were rarely victims of smallpox epidemic, a disease that in?icted a heavy toll on humankind with an estimate of 500 million victimsworldwide.In1796,Jennerinoculatedtheextracted?uidfromblistersonthe handofamilkmaidwhowasinfectedwithcowpoxintothearman8yearoldpeasant boy. After the boy recovered from a mild illness caused by this inoculation, Jenner exposed him to smallpox and to his delight the boy did not develop the disease. He published his work in 1798 in three publications titled "e;Vaccination Against smallpox"e;, where the term vaccination is derived from the Latin word "e;vacca"e; meaning cow. Jenner was recognized to be the father of modern immunology, and hisworkmarkedthecommencementofanewdawninmedicinethatledtothe1979 declaration by the World Health Organization (WHO) of the global eradication of smallpox. By the beginning of the 20th century, vaccines for typhoid fever, rabies, polio, plaque and diphtherias were in use, and nowadays we are equipped with effectivevaccinesagainstmorethan20infectiousdiseasessuchasmeningitis,rubella, whooping cough, rabies, and hepatitis B among others.

Inhalt

CONTENTS 6
PREFACE 8
I. BASIC TUMOR IMMUNOLOGY 11
1. ANTIGEN PROCESSING AND PRESENTATION 12
2. ANTIGEN RECOGNITION AND T- CELL BIOLOGY 46
3. MECHANISMS OF TUMOR EVASION 69
4. TUMOR ANTIGENS AND TUMOR ANTIGEN DISCOVERY 97
II. CANCER VACCINE DEVELOPMENT 120
5. PEPTIDE VACCINES AGAINST CANCER 121
6. DNA VACCINATION IN IMMUNOTHERAPY OF CANCER 143
7. ANTIBODY INDUCING POLYVALENT CANCER VACCINES 161
8. DENDRITIC CELL-BASED VACCINES FOR CANCER THERAPY 185
9. UNDEFINED-ANTIGEN VACCINES 210
10. CANCER VACCINES IN COMBINATION WITH MULTIMODALITY THERAPY 229
III. VACCINE-ENHANCING STRATEGIES 248
11. CYTOKINE THERAPY FOR CANCER: ANTIGEN PRESENTATION 249
12. TINKERING WITH NATURE: THE TALE OF OPTIMIZING PEPTIDE BASED CANCER VACCINES 267
13. TUMOR IMMUNOLOGY AND CANCER VACCINES 284
IV. CLINICAL TRIALS DESIGN 328
14. CLINICAL TRIAL DESIGNS FOR THERAPEUTIC CANCER VACCINES 329
15. CLINICAL TRIAL DESIGN AND REGULATORY ISSUES FOR THERAPEUTIC CANCER VACCINES 341
16. IMMUNE MONITORING 359
INDEX 379

Produkt-Details

• Erscheint lt. Verlag: 16.7.2007
• Reihe/Serie: Cancer Treatment and Research
• Reihe/Serie: Cancer Treatment and Research
• Zusatzinfo: X, 398 p. 100 illus.
• Verlagsort: New York
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
• Themenwelt: Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
• Schlagworte: Antigen • Antigen presentation • Cancer • Cancer Therapy • Cell Biology • clinical trial • Cytokine • DNA • immunotherapy • Research • Tumor • Vaccine
• ISBN-10: 0-387-27545-2 / 0387275452
• ISBN-13: 978-0-387-27545-1 / 9780387275451