Cancer Metastasis and the Lymphovascular System: (eBook)

Basis for Rational Therapy

Stanley P. L. Leong (Herausgeber)

eBook Download: PDF

2007 | 2007
XVII, 309 Seiten
Springer US (Verlag)
978-0-387-69219-7 (ISBN)

Infos

This book details the anatomy and physiology of the lymphovascular system as well as describes the mechanisms of metastasis. It provides readers with an understanding of immune responses of draining lymph nodes against cancer. Coverage also explains the rationale of adopting molecular therapeutics against growth factor receptors, apoptotic factors, signaling pathways and angiogenesis.

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Sentinel lymph node (SLN) procedures have opened a window of opportunity for the study of micrometastasis. In eighty percent (80%) of metastasis there lies an orderly pattern of progression via the lymphatic network, while 20% of the time systemic metastasis occurs, bypassing the lymphatic system. During the past two decades, significant progress has been achieved in understanding the anatomical, functional, cellular and molecular aspects of the lymphovascular system and the metastasis process. Molecular imaging advances help to localize early cancers more precisely. Current status of the immune responses in the draining lymph nodes against cancer is summarized. New paradigms of early cancer growth, proliferation, overcoming apoptosis are exploited in the development of anticancer treatment. In this book, basic scientists and clinicians exchange ideas so that laboratory findings can be applied to clinical dilemmas, and clinical problems can be targeted for research in the laboratory.

Inhalt

CONTENTS 6
CONTRIBUTORS 9
FOREWORD 13
PREFACE 15
ACKNOWLEDGMENTS 16
1. LANDMARKS AND ADVANCES IN TRANSLATIONAL LYMPHOLOGY 17
2. EMBRYONIC DEVELOPMENT OF THE LYMPHOVASCULAR SYSTEM AND TUMOR LYMPHANGIOGENESIS 33
3. LYMPHATIC ORIGIN FROM EMBRYONIC STEM CELLS 41
4. LYMPHATIC MARKERS, TUMOUR LYMPHANGIOGENESIS AND LYMPH NODE METASTASIS 54
5. ANATOMY OF THE HUMAN LYMPHATIC SYSTEM 69
6. SPECTÒCT FUSION IMAGING RADIONUCLIDE LYMPHOSCINTIGRAPHY: POTENTIAL FOR LIMB LYMPHEDEMA ASSESSMENT AND SENTINEL NODE DETECTION IN BREAST CANCER 92
7. SENTINEL NODE IDENTIFICATION USING RADIONUCLIDES IN MELANOMA AND BREAST CANCER 98
8. TARGETED INTRODUCTION OF SUBSTANCES INTO THE LYMPH NODES FOR ENDOLYMPHATIC THERAPY 114
9. MECHANISMS OF METASTASIS: SEED AND SOIL 132
10. PRECLINICAL MODELS OF REGIONAL LYMPH NODE TUMOR METASTASIS 141
11. A NEW BREAST CANCER MODEL FOR LYMPHATIC METASTASIS 169
12. LYMPH NODE MICROMETASTASES IN LUNG CANCER 178
13. EFFECTS OF CHEMOKINES ON TUMOR METASTASIS 187
14. REGIONAL LYMPH NODE METASTASES, A SINGULAR MANIFESTATION OF THE PROCESS OF CLINICAL METASTASES IN CANCER: CONTEMPORARY ANIMAL RESEARCH AND CLINICAL REPORTS SUGGEST UNIFYING CONCEPTS 195
15. PATTERNS OF METASTASIS IN HEAD AND NECK CANCER 212
16. PATTERNS OF METASTASIS IN HUMAN SOLID CANCERS 217
17. SIGNIFICANCE OF REGIONAL DRAINING LYMPH NODES IN THE DEVELOPMENT OF TUMOR IMMUNITY: IMPLICATIONS FOR CANCER IMMUNOTHERAPY 230
18. TARGETING SMALL MOLECULES IN CANCER 245
19. UPDATE ON THE ROLE OF EGFR INHIBITORS IN CANCER THERAPEUTICS 262
20. NEW PROMISES IN THE ADJUVANT, AND PALLIATIVE TREATMENT OF MELANOMA 281
21. FUTURE PERSPECTIVES AND UNANSWERED QUESTIONS ON CANCER METASTASIS AND THE LYMPHOVASCULAR SYSTEM 297
INDEX 301

Produkt-Details

• Erscheint lt. Verlag: 5.9.2007
• Reihe/Serie: Cancer Treatment and Research
• Reihe/Serie: Cancer Treatment and Research
• Zusatzinfo: XVII, 309 p.
• Verlagsort: New York
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Chirurgie
• Themenwelt: Medizinische Fachgebiete ► Innere Medizin ► Hämatologie
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
• Schlagworte: angiogenesis • Apoptosis • Imaging • lymphovascular • Metastasis
• ISBN-10: 0-387-69219-3 / 0387692193
• ISBN-13: 978-0-387-69219-7 / 9780387692197