Osteoporosis in Older Persons (eBook)

Pathophysiology and Therapeutic Approach

Gustavo Duque, Douglas P. Kiel (Herausgeber)

eBook Download: PDF

2009 | 2008
XVIII, 186 Seiten
Springer London (Verlag)
978-1-84628-697-1 (ISBN)

Infos

The book summarizes recent advances in the elucidation of the mechanisms involved in senile osteoporosis as well as its potential treatment, bringing an integrated approach from the bench to the clinical practice. A unique aspect of this book is its emphasis on the application of translational research in the field of osteoporosis and falls. The book provides a complete review on the prevention as well as current and future treatments of osteoporosis.

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Although osteoporosis has been de? ned as "e;a metabolic bone disease characterized by low bone mass and microarchitectural deterioration of bone tissue leading to enhanced bone fragility and a consequent increase in fracture risk,"e; it is not clear that osteoporosis represents a single disease as much as a similar response of bone to different pathophysiologies. In the 1940s Fuller Albright and colleagues recognized "e;osteoporosis of old age"e; and distinguished it from osteoporosis associated with the postme- pausal state, as well as from osteoporosis from disuse, osteoporosis from malnutrition, and other forms of osteoporosis. He nevertheless pointed out that it was unclear how much of osteoporosis is due to old age per se, in view of the fact that "e;in many cases osteoporosis of disuse, of malnutrition, of the postmenopausal state and of senility are inseparably superimposed. "e; In this volume, Duque and Kiel have gathered an international panel of experts to highlight the unique features of senile osteoporosis and cons- eration of this disease spans the very basic through the clinical and the epidemiologic. As an organ which harbors stem cells, bone may clearly in? uence not only its own regeneration but also the regeneration of other tissues, notably the hematopoietic system.

Inhalt

Foreword 6
Preface 8
Acknowledgments 11
Contents 12
Contributors 14
1 Biology of Bone 16
2 Aging and Bone 34
3 Calciotropic Hormones 49
4 Sex Steroids and Aging Bone 62
5 Animal Models for Senile Osteoporosis 74
6 Senile Osteoporosis as a Geriatric Syndrome 86
7 Genetics of Osteoporosis in Older Age 97
8 Fracture Epidemiology Among Individuals 75+ 112
9 Falls as a Geriatric Syndrome: How to Prevent Them? How to Treat Them? 125
10 Non-Pharmacological Treatments for Falls and Fractures 141
11 Medical Treatment of Age-Related Osteoporosis: Present and Future 152
12 Treatment of Osteoporosis in Long-Term Care 168
13 Fracture Care in the Elderly 178
Index 196

Produkt-Details

• Erscheint lt. Verlag: 13.10.2009
• Zusatzinfo: XVIII, 186 p.
• Verlagsort: London
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Chirurgie
• Themenwelt: Medizinische Fachgebiete ► Innere Medizin ► Rheumatologie
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Orthopädie
• Schlagworte: aging • Fractures • Geriatrics • Osteoporosis • Sex • Steroids
• ISBN-10: 1-84628-697-2 / 1846286972
• ISBN-13: 978-1-84628-697-1 / 9781846286971