Challenging Cases in Allergic and Immunologic Diseases of the Skin (eBook)

Massoud Mahmoudi (Herausgeber)

eBook Download: PDF

2010 | 2010
XIII, 347 Seiten
Springer New York (Verlag)
978-1-60761-296-4 (ISBN)

Infos

Challenging Cases in Allergic and Immunologic Diseases of the Skin offers clinicians a wide range of challenging cases that are certain to provide hours of thoughtful and instructive review. Using a case study format and including excellent quality color images, Challenging Cases in Allergic and Immunologic Diseases of the Skin consists of five parts and 20 chapters. The chapters cover such areas as allergic rhinitis, allergic diseases of the eye, drug-induced urticaria, cosmetic allergy, drug allergy, latex allergy, atopic dermatitis, vasculitis, and a range of other commonly seen disorders of the skin. Each chapter comprises at least two cases that are followed by a differential diagnosis, discussion, and five multiple choice questions for thoughtful stimulation and excellent value as a teaching tool. Comprehensive, concise, and well-designed in presentation, Challenging Cases in Allergic and Immunologic Diseases of the Skin is a one-of-a-kind resource that will become a standard resource for all clinicians who care for patients with allergic and immunologic diseases of the skin.

Inhalt

Challenging Cases inAllergic and ImmunologicDiseases of the Skin 3
Preface 7
Contents 9
Contributors 11
Part I Urticaria and Angioedema 15
Chapter 1: Urticaria 16
Case 1 16
With the Presented Data What Is Your Working Diagnosis? 18
Differential Diagnosis 18
Workup 18
What Is Your Diagnosis and Why? 19
Management and Follow-Up 19
Questions 19
Case 2 20
With the Presented Data What Is Your Working Diagnosis 22
Differential Diagnosis 23
Workup 23
What Is Your Diagnosis and Why? 24
Management and Follow-Up 24
Questions 24
Discussion 25
Definition 25
Brief History 25
Prevalence of Urticaria 26
Pathophysiology 26
Clinical Manifestations 27
Ordinary Urticaria 27
Physical Urticaria 28
Urticaria due to Mechanical Stimuli 28
Dermographism 28
Immediate Pressure Urticaria 28
Delayed Pressure Urticaria 29
Vibratory Angioedema 29
Temperature Change Urticaria 29
Heat Urticaria 29
Cold Urticaria 29
Exercise-Induced Anaphylaxis 30
Solar Urticaria 30
Aquagenic Urticaria 30
Contact Urticaria 30
Angioedema Without Wheals 31
Urticarial Vasculitis 31
Urticarial Syndromes 31
Muckle–Wells Syndrome 31
Schnitzler Syndrome 32
Autoimmune Progesterone Dermatitis 32
Diagnostic Procedures 32
History-Taking 32
Laboratory Test 33
Treatment 33
Conclusion 35
References 35
Chapter 2: Cold Urticaria 37
Case 1 37
With the Presented Data, What Is Your Working Diagnosis? 38
Differential Diagnosis 38
Work-Up 39
What Is Your Diagnosis and Why? 39
Follow-up 39
Case 2 40
With the Presented Data, What Is Your Working Diagnosis? 42
Differential Diagnosis 42
Work-Up 42
What Is Your Diagnosis and Why? 43
Discussion 43
Definition 43
Differential Diagnosis 44
Pathophysiology 46
Presentation 46
Work-Up 46
Treatment 52
Questions 54
References 55
Chapter 3: Contact Urticaria Syndrome 57
Introduction 57
Case 1 57
Chief Complaint 57
History of Present Illness 58
Past Medical History 58
Physical Examination 58
Differential Diagnosis 58
Impression and Follow-Up 58
Case 2 59
Chief Complaint 59
History of Present Illness 59
Family History 59
Review of Systems 59
Social History 59
Physical Examination 60
Differential Diagnosis 60
Impression and Follow-Up 60
Discussion 60
History 60
Prevalence 61
Pathophysiology 63
Clinical Presentation, Testing, and Diagnosis 65
Treatment 67
Questions 68
References 70
Chapter 4: Idiopathic Angioedema 71
Case 1 71
With the Presented Data, What is Your Working Diagnosis? 74
Workup 74
What is Your Diagnosis and Why? 75
Case 2 76
With Presented Data, What Is Your Working Diagnosis? 77
Workup 77
What Is Your Diagnosis and Why? 78
Discussion 79
Evaluation 80
Workup 80
Management 81
Questions 82
References 83
Chapter 5: Hereditary Angioedema 85
Case 1 85
With the Above Data, What Is Your Working Diagnosis? 87
Work-Up 88
What Is Your Diagnosis and Why? 89
Case 2 89
With These Presented Data What Is Your Working Diagnosis? 90
Work-Up 91
What Is Your Diagnosis and Why? 92
Discussion 92
Pathophysiology 95
Work-Up 95
Management and Treatment 96
Questions 98
References 100
Part IISkin Manifestation of Drug Allergy 101
Chapter 6: Stevens–Johnson Syndrome/Toxic Epidermal Necrolysis 102
Case 1 102
Data 103
Discussion 105
Case 2 108
Data 109
Discussion 110
Questions 111
Case 2 115
Case 3 117
References 119
Chapter 7: Serum Sickness and Serum Sickness-Like Reaction 121
Case 1 121
Diagnostic Testing (Results from 2005) 123
With the Presented Data, What Is Your Working Diagnosis? 123
Impression 123
Plan 123
Differential Diagnoses 123
Workup 124
What Is Your Diagnosis and Why? 124
Case 2 125
Data 126
With the Presented Data, What Is Your Working Diagnosis? 126
Workup 127
What Is Your Diagnosis and Why? 127
Discussion 129
Questions 131
References 133
Part IIIAllergic Contact Dermatitis 134
Chapter 8: Preservatives 135
Case 1 135
With the Presented Data, What Is Your Working Diagnosis? 136
Differential Diagnosis 136
Workup 136
What Is Your Diagnosis and Why? 136
Management and Follow-Up 136
Case 2 137
With the Presented Data, What Is Your Working Diagnosis? 137
Differential Diagnosis 137
Workup 137
What Is Your Diagnosis and Why? 137
Management and Follow-Up 138
Discussion 138
Definition 138
Brief History 138
Prevalence of AC.D and Types of Preservatives 139
Formaldehyde 139
Quaternium-15 141
Imidazolidinyl Urea 142
2,5-Diazolidinyl Urea 142
Methylchloroisothiazolinone/Methylisothiazolinone 143
Methyldibromoglutaronitrile (MDBNG)/phenoxyethanol 143
Parabens 143
Pathophysiology 144
Diagnostic Procedures 144
Conclusion 145
Questions 145
References 147
Chapter 9: Allergic Contact Dermatitis: Rubber Allergies 148
Case 1 148
History of Present Illness 148
Physical examination 149
Differential diagnosis 149
Working diagnosis 149
Impression and follow-up 149
Case 2 149
History of present illness 149
Physical examination 150
Differential 150
Working diagnosis 150
Impression and follow-up 150
Discussion 150
Historical Background 150
Prevalence of Rubber-Based Contact Dermatitis 151
Immunology and Pathophysiology of Rubber Allergic Contact Dermatitis 152
Clinical Manifestations of Rubber Allergic Contact Dermatitis 154
Diagnosis and Treatment 156
Questions 157
References 158
Chapter 10: Jewelry: Nickel and Metal-Based Allergic Contact Dermatitis 160
Case 1 160
History of Present Illness 160
Physical Examination 161
Differential Diagnosis 161
Working Diagnosis 161
Impression and Follow-Up 161
Case 2 161
History of Present Illness 161
Physical Examination 162
Differential Diagnosis 162
Working Diagnosis 162
Impression and Follow-Up 162
Discussion 163
Historical Background 163
Prevalence of Metal-Based Contact Dermatitis 163
Impact of Patient Factors on Contact Allergy with Nickel and other Metals 164
Immunology and Pathophysiology of Metal ACD 165
Allergenicity of Gold, Cobalt, and Palladium 167
Gold 167
Cobalt 167
Palladium 168
Clinical Presentation of Metal Allergy 168
Diagnosis and Treatment 169
Questions 172
References 174
Chapter 11: Allergic Contact Dermatitis to Fragrances 176
Case 1 176
With the Presented Data, What Is Your Working Diagnosis? 177
Differential Diagnosis 177
Work-Up 177
What Is Your Diagnosis and Why? 177
Management and Follow-Up 177
Case 2 178
With the Presented Data, What Is Your Working Diagnosis? 178
Differential Diagnosis 178
Work-Up 178
What Is Your Diagnosis and Why? 178
Management and Follow-Up 179
Case 3 179
With the Presented Data, What Is Your Working Diagnosis? 179
Differential Diagnosis 179
Work-Up 179
What Is Your Diagnosis and Why? 180
Management and Follow-Up 180
Discussion 180
Definition 180
History and Prevalence 180
Pathophysiology 181
Clinical Presentation, Testing, and Diagnosis 181
Conclusion 184
Questions 184
References 187
Part IVOther Allergies Affecting Skinand Mucous Membranes 188
Chapter 12: Atopic Dermatitis 189
Case 1 189
With the Presented Data, What is Your Working Diagnosis? 191
Workup 192
Data 192
What is Your Diagnosis and Why? 192
Management and Follow-Up 192
Case 2 193
With the Presented Data, What is Your Working Diagnosis? 193
Workup 194
Data 195
What is Your Diagnosis and Why? 196
Management and Follow-Up 196
Discussion 198
Prevalence 198
Typical Presentation 198
Histology 199
Genetics 199
Immunology 200
Diagnosis 201
Treatment 201
Questions 204
References 206
Chapter 13: Allergic Reactions Affecting Mucosal Surfaces 207
Case 1 207
Laboratory Data 208
Initial Impression 208
Differential Diagnosis 208
Clinical Evaluation 209
Identification and Confirmation of Relevant Seminal Plasma Sensitizing Proteins 209
Gel Filtration Chromatography 209
IgE-Specific Enzyme-Linked Immunosorbent Assay and ELISA Inhibition 210
Sodium dodecyl sulfate – polyacrylamide gel electrophoresis and Western Immunoblotting of SP 211
With the Presented Data, What Is Your Diagnosis? 211
Discussion 211
Questions 213
Case 2 214
Laboratory Data 214
Initial Impression 214
Differential Diagnosis 215
Clinical Evaluation 215
IgE Measurement and C. albicans Immunocap Testing 215
With the Presented Data, What Is Your Diagnosis? 215
Discussion 215
Questions 218
References 219
Part VImmunologic Diseases of the Skin 221
Chapter 14: Vasculitis 222
Case 1 222
Data 223
Imaging Studies 223
Discussion 223
Case 2 228
Data 228
Imaging Studies 229
Discussion 229
Questions 231
Case 1 231
Case 2 233
Case 3 236
Answers 239
Questions 239
References 239
Chapter 15: Cutaneous Mastocytosis 241
Case 1 241
With the Presented Data, What is Your Working Diagnosis? 243
Differential Diagnosis 243
Workup 243
What is Your Diagnosis and Why? 244
Case 2 244
With the Presented Data, What is Your Working Diagnosis? 245
Differential Diagnosis 245
Workup 245
What is Your Diagnosis and Why? 246
Discussion 247
Questions 252
References 254
Chapter 16: Cutaneous Lupus 255
Case 1 255
Data 257
With the Presented Data, What Is Your Working Diagnosis? 257
Workup 258
Skin Biopsy 258
What is Your Diagnosis and Why? 258
Discussion 258
Questions 261
Case 2 262
With the Presented Data, What Is Your Working Diagnosis? 264
Workup 264
What is Your Diagnosis and Why? 264
Discussion 266
Questions 268
References 269
Chapter 17: Psoriasis 270
Clinical Presentation 270
Case 1 270
What Is Your Working Diagnosis? 271
Differential Diagnosis 271
Workup 271
What Is Your Diagnosis and Why? 271
Management and Treatment 272
Case 2 272
What Is Your Working Diagnosis? 272
Differential Diagnosis 273
Workup 273
What Is Your Diagnosis and Why? 273
Management and Follow-Up 273
Discussion 274
Background 274
Pathophysiology 274
Brief History 274
Molecular Pathogenesis 274
Genetics 275
Clinical Manifestations 276
Plaque Psoriasis 276
Erythrodermic Psoriasis 277
Guttate Psoriasis 277
Pustular Psoriasis 278
Inverse Psoriasis 279
Psoriatic Arthritis 279
Other Clinical Findings 279
Psoriasis and Other Comorbidities 279
Differential Diagnosis 280
Management 281
History 281
Diagnostic Procedures 281
Treatment 283
Conclusion 284
Questions 285
References 287
Chapter 18: Scleroderma 289
Case 1 289
What Is Your Initial Impression About This Patient? 291
Differential Diagnosis 292
With the Presented Data, What Is Your Diagnosis and Why? 294
Discussion 294
Questions 296
Case 2 297
With the Presented Data, What Is Your Working Diagnosis? 298
Differential Diagnosis 299
Workup 299
What Is Your Diagnosis and Why? 300
Discussion 300
Questions 302
References 303
Chapter 19: Autoimmune Blistering Diseases of the Skin and Mucous Membranes 305
Case 1 305
What Is the Differential Diagnosis? 306
What Is the Appropriate Workup in This Patient? 307
Test Results 308
Based on the Histology and Immunofluorescence Findings, What Is the Best Diagnosis in This Patient? 308
What Is the Appropriate Treatment for This Patient? 308
What Is the Significance of Lichenoid Dermatitisin a Patient With Pemphigus? 309
With the Consideration of Paraneoplastic Pemphigus, What Should the Next Step Be in the Workup of the Patient? 310
Discussion 312
Case 2 313
What Is the Differential Diagnosis? 314
What Is the Next Step in the Workup of the Patient? 315
With These Clinical and Pathologic Findings, What Is Your Best Diagnosis? 316
Is There Any Test That Can Be Performed to Differentiate Between MMP and EBA? 318
With MMP as the Most Likely Diagnosis, How Shouldthe Management of This Patient Proceed? 318
Given That Conservative Treatment Measures Have Failed, What Is the Next Step? 319
With These New Ocular Findings, How Does This Change Therapy? 319
Discussion 320
Questions 321
References 323
Chapter 20: Alopecia Areata* 324
Case 1 324
Case Presentation 324
With the Presented Data What Is Your Working Diagnosis? 325
Differential Diagnosis 325
Work-Up 326
What Is Your Diagnosis and Why? 326
Case 2 327
Case Presentation 327
Data 328
With the Presented Data What Is Your Working Diagnosis? 328
Differential Diagnosis 328
Work-Up 329
What Is Your Diagnosis and Why? 329
Discussion 330
Definition/Epidemiology 330
Presentation 330
Pathophysiology/Genetics 332
Work-Up 333
Management/Prognosis 333
Questions 337
References 338
Index 340

Produkt-Details

• Erscheint lt. Verlag: 8.9.2010
• Zusatzinfo: XIII, 347 p.
• Verlagsort: New York
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Gesundheitswesen
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Allgemeinmedizin
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Dermatologie
• Schlagworte: AIDS related skin lesions • Allergic • Allergie • Angioedema • Atopic D • Atopic dermatitis • Chemical-induced Allergies • contact dermatitis • Cosmetic Allergy • Cutaneous Lupus • Cutaneous Mastocytosis • Dermatologic • Immunologic • Immunologic Diseases of the Skin • Immunot • Interactions of skin and enviromental allergens • Physical Urticaria • Poison Ivy • Rhinitis • skin diseases • urticaria
• ISBN-10: 1-60761-296-8 / 1607612968
• ISBN-13: 978-1-60761-296-4 / 9781607612964