Herpes Simplex Virus Epithelial Keratitis (eBook)

In Vivo Morphology in the Human Cornea

Helena M. Tabery (Autor)

eBook Download: PDF

2009 | 2010
XIV, 58 Seiten
Springer Berlin (Verlag)
978-3-642-01012-5 (ISBN)

Infos

As a young ophthalmologist, I found corneal epithelial diseases a subject diffcult to grasp. One day, it occurred to me that the reason might be a lack of images showing the nature of the components of the changes visible with the slit lamp. With the slit lamp, the inevitable eye movements that blur the image limited the magnifcation level, but perhaps photography might be the answer. It was not a short journey, but in the end the idea proved right. By trial and error, the quality of the images improved, and after some time, I found that the resolution allowed reasonable comparisons with available images of histological preparations. Such comparisons allowed better und- standing of the substructures of epithelial in vivo lesions and, in conjunction with their in vivo dynamic features, eventually an understanding of at least some mechanisms behind them. This book, originating from over 20 years of experience with observations of ocular surface changes at high magnifcation level, covers several aspects of corneal epithelial lesions caused in humans by herpes simplex virus: various shapes of the lesions, their substructure and mechanisms behind them; morphological features of the healing p- cess, sequelae, complications, and some accompanying signs; and some rare cases. For those less familiar with the slit lamp image, I have added explanatory drawings to facilitate comprehension.

Inhalt

Herpes Simplex Virus Epithelial Keratitis 1
The Morphology of Herpes Simplex Virus Epithelial Keratitis 10
Anchor 3 10
HSV Cytopathic Effect: Early Changes 11
Comment 12
HSV Cytopathic Effect: Advanced Changes 13
Comment 14
Early HSV In Vivo Lesions: Surface Elevation and Disruption 15
An Advanced HSV In Vivo Lesion: Loss of Substance 16
HSV Lesions: Surface Elevation, Depression, and Fluid Diffusion 17
HSV Lesions: Epithelial and Stromal Fluid Diffusion 18
Optical Section Through the Cornea 18
Rose Bengal Dye Staining of HSV Lesions 19
Comment 20
An HSV Dendritic Figure 21
Comment 22
An HSV Dendritic Figure (Continued) 23
The Origin of HSV Dendritic Figures 25
Various Shapes of HSV Dendritic Figures 26
Some Other Shapes of HSV Lesions 27
Comment 27
Comment 27
Precursors of HSV Geographic Lesions 29
HSV Geographic Lesions 30
Comment 30
A Case of Primary HSV Keratitis 31
Case Report 31
Addendum: HSV Conjunctival Lesions 32
Comment 32
Healing of Herpes Simplex Virus Epithelial Keratitis Treated with Acyclovir Ointment and Short-Term Sequelae of the Infection 33
Anchor 3 33
Healing of HSV Epithelial Keratitis with Acyclovir Ointment 34
Case Report 35
Healing of HSV Epithelial Keratitis with Acyclovir Ointment 36
Healing of HSV Epithelial Keratitis with Acyclovir Ointment 37
Case Report 37
Healing of HSV Epithelial Keratitis with Acyclovir Ointment 38
Healing of HSV Epithelial Keratitis with Acyclovir Ointment 40
Case Report 40
Healing of HSV Epithelial Keratitis with Acyclovir Ointment: A Treatment Failure 41
Case Report 41
Side Effects of Acyclovir Ointment 42
Comment 42
Complications, Accompanying Signs, Recurrences, and Long-Term Sequelae of Herpes Simplex Virus Epithelial Keratitis 43
Anchor 3 43
Case 1. HSV Epithelial Keratitis: A Fresh and an Older Lesion 44
Case Report 44
Comment 45
Healing Followed by Epithelial Breakdown and a New Repair (Case 1, cont.) 46
Case 2. Healing of HSV Epithelial Keratitis, Accompanying Signs, and Sequelae 48
Case ReportA 72-year-old woman with severe visual impairment in her right eye (caused by macular degeneration) presented with 48
Healing of HSV Epithelial Keratitis, Accompanying Signs, and Sequelae (Case 2, cont.) 52
Healing of HSV Epithelial Keratitis, Accompanying Signs, and Sequelae (Case 2, cont.) 54
Healing of HSV Epithelial Keratitis, Accompanying Signs, and Sequelae (Case 2, cont.) 56
Addendum 56
Case 3. HSV Epithelial Keratitis and Stromal Infiltrates 57
Case Report 57
Case 4. HSV Epithelial Keratitis Preceded by Anterior Uveitis and Disciform Keratitis 58
Case Report 58
Addendum 58
HSV Epithelial Keratitis and Dry Eye (Case 4, cont.) 59
Case 5. Recurrent HSV Epithelial Keratitis in a Patient with Dry Eye 60
Case Report 60
Bibliography 62
Index 63

Produkt-Details

• Erscheint lt. Verlag: 20.10.2009
• Zusatzinfo: XIV, 58 p. 72 illus. in color.
• Verlagsort: Berlin
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Allgemeines / Lexika
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete
• Schlagworte: cornea • Herpes simplex virus • HSV • Human • Infection • Infectious Diseases • In Vivo photomicrography • Virus
• ISBN-10: 3-642-01012-1 / 3642010121
• ISBN-13: 978-3-642-01012-5 / 9783642010125