Clinical Nephrotoxins (eBook)

Renal Injury from Drugs and Chemicals

Marc E. de Broe, George A. Porter (Herausgeber)

eBook Download: PDF

2008 | 3., Third Edition 2008
XVII, 987 Seiten
Springer US (Verlag)
978-0-387-84843-3 (ISBN)

Infos

Clinical Nephrotoxins: Renal Injury from Drugs and Chemicals, Third Edition is a comprehensive text on all aspects of adverse effects by drugs, chemical substances and radiation on the kidneys. The importance of the toxicity of drugs and other substances for the kidneys is increasingly recognized. The book consists of themes such as clinical relevance, renal handling and cellular mechanisms of nephrotoxicity, as well as animal and cell culture models. In addition, the volume highlights specific types of drugs, such as anti-infectious agents and anti-inflammatory, cardiovascular and anti-cancer drugs. The last section deals with prevention and focuses on urinary biomarkers, pharmacological aspects and drug dosage in renal failure. In this third and completely revised edition, several new topics were added and additional figures and tables will be included.

The book is of interest for the nephrologist, internist, general practitioner, toxicologist, pharmacologist, anesthesiologist, epidemiologist, public health official, pharmaceutical industry, and national drug safety committees, among others.

Inhalt

TABLE OF CONTENTS 5
Preface 8
LIST OF CONTRIBUTORS 9
GENERAL 16
Clinical relevance 17
Drug-associated acute kidney injury in the intensive care unit 43
Renal handling of drugs and xenobiotics 56
Pharmacological aspects of nephrotoxicity 85
Pharmacovigilance: from signal to action 96
Urinary biomarkers and nephrotoxicity 102
Toxin-induced immunological renal disease 142
Cellular mechanisms of nephrotoxicity 165
Animal models for the assessment of acute renal dysfunction and injury 181
Renal cell culture models: Contribution to the understanding of nephrotoxic mechanisms 230
Use of dialytic therapies for poisoning 257
SPECIFIC DRUGS 271
Aminoglycosides and vancomycin 272
Beta-lactam antibiotics 298
Amphotericin B 327
Sulfonamides, sulfadiazine, trimethoprim- sulfamethoxazole, pentamidine, pyrimethamine, dapsone, quinolones 357
Antiviral agents 386
Analgesics and 5-aminosalicylic acid 402
Non-steroidal anti-inflammatory drugs 421
Gold salts, D-penicillamine and allopurinol 460
Angiotensin I converting enzyme inhibitors and angiotensin II receptor antagonists 481
Diuretics and alcohol ingestion 495
Anticancer drugs 510
Anesthetic agents 535
Bisphosphonates and the kidney 545
Proton pump inhibitors: acute interstitial nephritis and other renal effects 565
Oral sodium phosphate bowel purgatives and acute phosphate nephropathy 576
Illicit drug abuse and renal disease 592
Nephrotoxicity of calcineurin and mTOR inhibitors 614
Immunomodulators: interleukins, interferons, and IV immunoglobulin 680
Imaging agents 696
Lithium-associated kidney effects 722
Oxalate 746
Herbal remedies containing aristolochic acid and mushroom nephrotoxicity 754
Environmental and Occupational Nephrotoxins 767
Lead nephropathy 768
Cadmium-induced renal effects 779
Mercury-induced renal effects 805
Organic solvents, silicon- containing compounds and pesticides 821
Balkan nephropathy 836
Nephrotoxins in Africa 852
Paraphenylene diamine hair dye poisoning 864
The Renal Failure Patient 873
Trace metal disturbances in end- stage renal failure patients 874
Smoking and the kidney 886
Star fruit 892
Drug dosage in renal failure 904
LIST OF ABBREVIATIONS 935
INDEX 941

Produkt-Details

• Erscheint lt. Verlag: 15.9.2008
• Mitarbeit: Anpassung von: William M. Bennett, Gilbert Deray
• Zusatzinfo: XVII, 987 p.
• Verlagsort: New York
• Sprache: englisch
• Themenwelt: Medizinische Fachgebiete ► Innere Medizin ► Nephrologie
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
• Schlagworte: Antibiotic • Intensive care • Interferon • Internist • kidney • nephrotoxins, renal injury, drugs, urinary biomarkers • prevention
• ISBN-10: 0-387-84843-6 / 0387848436
• ISBN-13: 978-0-387-84843-3 / 9780387848433