Breast Cancer and its Precursor Lesions (eBook)

Making Sense and Making It Early

Patricia A. Thomas (Herausgeber)

eBook Download: PDF

2010 | 2011
X, 80 Seiten
Humana Press (Verlag)
978-1-60327-154-7 (ISBN)

Infos

Rather than an exhaustive review of all the pathologic conditions of the female breast, Breast Cancer and its Precursor Lesions focuses on the current knowledge, understanding and issues related to breast cancer and its benign lesions that are associated with an increased risk for the subsequent development of cancer. This book targets the language, diagnostic terms and critical communication that must take place between primary care physicians, breast surgeons, oncologists, and general surgical pathologists interested in the pathologist's perspective on these important diseases. The volume also reviews the current terminology and how to read or write meaningful pathology reports on these entities, the foils and nuances of the pathology and implications for management, and up to date issues in genomics and proteomics of these conditions. The text is succinct, fully informative, and written in 'plain language'. All chapters are presented in a uniform fashion, and supplemented by high-quality illustrations and tables. Breast Cancer and its Precursor Lesions will be of great value to pathologists as well as primary care physicians, breast surgeons, and oncologists for understanding breast pathology and its implications for management.

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Rather than an exhaustive review of all the pathologic conditions of the female breast, Breast Cancer and its Precursor Lesions focuses on the current knowledge, understanding and issues related to breast cancer and its benign lesions that are associated with an increased risk for the subsequent development of cancer. This book targets the language, diagnostic terms and critical communication that must take place between primary care physicians, breast surgeons, oncologists, and general surgical pathologists interested in the pathologist's perspective on these important diseases. The volume also reviews the current terminology and how to read or write meaningful pathology reports on these entities, the foils and nuances of the pathology and implications for management, and up to date issues in genomics and proteomics of these conditions. The text is succinct, fully informative, and written in "e;plain language"e;. All chapters are presented in a uniform fashion, and supplemented by high-quality illustrations and tables. Breast Cancer and its Precursor Lesions will be of great value to pathologists as well as primary care physicians, breast surgeons, and oncologists for understanding breast pathology and its implications for management.

Inhalt

Preface 6
Contents 8
Contributors 10
Chapter 1: Overview 11
Introduction 11
Incidence and Epidemiology 12
Risk Factors 12
Race/Ethnicity and Culture 13
Prognostic and Predictive Factors 14
References 16
Chapter 2: Common Benign Conditions of Low Concern 17
Benign Conditions Associated with No Risk 18
Reactive and inflammatory lesions 19
Nonproliferative fibrocystic changes 21
Deciphering the Pathology Report 21
References 22
Chapter 3: Benign Conditions Associated with a Risk for the Subsequent Development of Cancer 23
Proliferative Breast Disease Without Atypia 24
Usual Ductal Hyperplasia 24
Deciphering the Pathology Report 26
Sclerosing Adenosis 26
Deciphering the Pathology Report 27
Complex Sclerosing Lesion (Radial Scar) 27
Deciphering the Pathology Report 28
Papilloma 28
Deciphering the Pathology Report 30
Atypical Ductal Hyperplasia 30
Deciphering the Pathology Report 33
Lobular Hyperplasia with Atypia 33
Deciphering the Pathology Report 33
Flat Epithelial Atypia 33
Deciphering the Pathology Report 34
References 35
Chapter 4: Precursor Lesions and Noninvasive Cancers 36
Lobular Neoplasia 36
Clinical Presentation 39
Risk Factors and Diagnosis 40
Implications and Relationship to Malignancy 41
Implications for Management 41
Deciphering the Pathology Report 43
Ductal Carcinoma In Situ 43
Clinical Presentation 44
Risk Factors and Diagnosis 44
Deciphering the Pathology Report 44
References 46
Chapter 5: Breast Cancer 49
Invasive Ductal Carcinoma 49
Clinical Presentation 51
Risk Factors and Diagnosis 51
Deciphering the Pathology Report 53
Invasive Lobular Carcinoma 54
Clinical Presentation 55
Risk Factors and Diagnosis 56
Deciphering the Pathology Report 56
Breast Cancer: The Special Types 56
Terminology, Clinical Presentation and Implications for Management 56
Deciphering the Pathology Report 59
References 59
Chapter 6: Things Pathologists Must Always Consider 60
Mimics of Malignancy 60
Fibromatosis 60
Fat Necrosis 61
Granulomatous Mastitis 62
Radial Scar 62
Granular Cell Tumor 64
What Should Always Be in Any Pathology Report? 65
The Pathology Report 65
What Are the Limitations of Biopsy Techniques? 67
Core Needle Biopsy 67
What Are the Limitations of Fine Needle Aspiration Biopsy? 68
References 68
Chapter 7: Nuances and Details of the Pathology Report 70
Equivocal or Non-committal Diagnoses 70
In Situ vs. Microinvasive vs. Invasive Breast Carcinoma 71
Lobular Extension/Pagetoid Spread 71
Prognostic Information That Can Be Obtained from the Pathology Report 72
Tumor Size 72
Histologic Grade 73
Lymph Node Status 74
Lymphovascular Invasion 74
Perineural Invasion 74
Tumor Margins 74
Extent of Ductal Carcinoma In Situ 75
Involvement of Skin and Nipple 75
Molecular Markers in Breast Cancer 76
Molecular Subtypes of Invasive Breast Cancer 78
Clinical and Pathologic Stage 80
Neoadjuvant vs. Adjuvant Therapy and Pathologists’ Role 80
References 81
Index 83

Produkt-Details

• Erscheint lt. Verlag: 20.10.2010
• Reihe/Serie: Current Clinical Pathology
• Reihe/Serie: Current Clinical Pathology
• Zusatzinfo: X, 80 p. 46 illus., 41 illus. in color.
• Verlagsort: Totowa
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
• Themenwelt: Studium ► 2. Studienabschnitt (Klinik) ► Pathologie
• ISBN-10: 1-60327-154-6 / 1603271546
• ISBN-13: 978-1-60327-154-7 / 9781603271547