Atlas of Hematologic Neoplasms (eBook)
XI, 525 Seiten
Springer US (Verlag)
978-0-387-89848-3 (ISBN)
Due to its rapid development in recent years, hematopathology has become a very complicated discipline. The current development is mainly in two aspects: the new classification of lymphomas and leukemias and the new techniques.
The Revised European-American Classification of Lymphoid Neoplasms (REAL classification) and the World Health Organization (WHO) classification of hematologic neoplasms require not only morphologic criteria but also immunophenotyping and molecular genetics for the diagnosis of hematologic tumors. Immunophenotyping is performed by either flow cytometry or immunohistochemistry. There are many new monoclonal antibodies and new equipments accumulated in recent years that make immunophenotyping more or more accurate and helpful. There are even more new techniques invented in recent years in the field of molecular genetics. In cytogenetics, the conventional karyotype is supplemented and partly replaced by the fluorescence in situ hybridization (FISH) technique. The current development of gene expression profiling is even more powerful in terms of subtyping the hematologic tumors, which may help guiding the treatment and predict the prognosis. In molecular biology, the tedious Southern blotting technique is largely replaced by polymerase chain reaction (PCR). The recent development in reverse-transcriptase PCR and quantitative PCR makes these techniques even more versatile.
Because of these new developments, hematopathology has become too complicated to handle by a general pathologist. Many hospitals have to hire a newly trained hematopathologist to oversee peripheral blood, bone marrow and lymph node examinations. These young hematopathologists are geared to the new techniques, but most of them are inexperienced in morphology. No matter how well-trained a hematopathologist is, he or she still needs to see enough cases so that they can recognize the morphology and use the new techniques to substantiate the diagnosis. In other words, morphology is still the basis for the diagnosis of lymphomas and leukemias.
Therefore, a good color atlas is the most helpful tool for these young hematopathologists and for the surgical pathologists who may encounter a few cases of hematologic tumors from time to time. In a busy daily practice, it is difficult to refer to a comprehensive hematologic textbook all the time. There are a few hematologic color atlases on the market to show the morphology of the normal blood cells and hematologic tumor cells. These books are helpful but not enough, because tumor cell morphology is variable from case to case and different kinds of tumor cells may look alike and need to be differentiated by other parameters.
The best way to learn morphology is through the format of clinical case study. This format is also consistent with the daily practice of hematopathologists and with the pattern in all the specialty board examinations. Therefore, it is a good learning tool for the pathology residents, hematology fellows as well as medical students.
This proposed book will present 83 clinical cases with clinical history, morphology of the original specimen and a list of differential diagnoses. This is followed by further testing with pictures to show the test results. At the end, a correct diagnosis is rendered with subsequent brief discussion on how the diagnosis is achieved. A few useful references will be cited and a table will be provided for differential diagnosis in some cases.
The major emphasis is the provision of 500 color photos of peripheral blood smears, bone marrow aspirates, core biopsy, lymph node biopsy and biopsies of other solid organs that are involved with lymphomas and leukemias. Pictures of other diagnostic parameters, such as flow cytometric histograms, immunohistochemical stains, cytogenetic karyotypes, fluorescence in situ hybridization and polymerase chain reaction, will also be included.
A comprehensive approach with consideration of clinical, morphologic, immunophenotypic and molecular genetic aspects is the best way to achieve a correct diagnosis. After reading this book, the reader will learn to make a diagnosis not only based on the morphology alone but also in conjunction with other parameters.
Due to its rapid development in recent years, hematopathology has become a very complicated discipline. The current development is mainly in two aspects: the new classification of lymphomas and leukemias and the new techniques.The Revised European-American Classification of Lymphoid Neoplasms (REAL classification) and the World Health Organization (WHO) classification of hematologic neoplasms require not only morphologic criteria but also immunophenotyping and molecular genetics for the diagnosis of hematologic tumors. Immunophenotyping is performed by either flow cytometry or immunohistochemistry. There are many new monoclonal antibodies and new equipments accumulated in recent years that make immunophenotyping more or more accurate and helpful. There are even more new techniques invented in recent years in the field of molecular genetics. In cytogenetics, the conventional karyotype is supplemented and partly replaced by the fluorescence in situ hybridization (FISH) technique. The current development of gene expression profiling is even more powerful in terms of subtyping the hematologic tumors, which may help guiding the treatment and predict the prognosis. In molecular biology, the tedious Southern blotting technique is largely replaced by polymerase chain reaction (PCR). The recent development in reverse-transcriptase PCR and quantitative PCR makes these techniques even more versatile. Because of these new developments, hematopathology has become too complicated to handle by a general pathologist. Many hospitals have to hire a newly trained hematopathologist to oversee peripheral blood, bone marrow and lymph node examinations. These young hematopathologists are geared to the new techniques, but most of them are inexperienced in morphology. No matter how well-trained a hematopathologist is, he or she still needs to see enough cases so that they can recognize the morphology and use the new techniques to substantiate the diagnosis. In other words, morphology is still the basis for the diagnosis of lymphomas and leukemias.Therefore, a good color atlas is the most helpful tool for these young hematopathologists and for the surgical pathologists who may encounter a few cases of hematologic tumors from time to time. In a busy daily practice, it is difficult to refer to a comprehensive hematologic textbook all the time. There are a few hematologic color atlases on the market to show the morphology of the normal blood cells and hematologic tumor cells. These books are helpful but not enough, because tumor cell morphology is variable from case to case and different kinds of tumor cells may look alike and need to be differentiated by other parameters. The best way to learn morphology is through the format of clinical case study. This format is also consistent with the daily practice of hematopathologists and with the pattern in all the specialty board examinations. Therefore, it is a good learning tool for the pathology residents, hematology fellows as well as medical students. This proposed book will present 83 clinical cases with clinical history, morphology of the original specimen and a list of differential diagnoses. This is followed by further testing with pictures to show the test results. At the end, a correct diagnosis is rendered with subsequent brief discussion on how the diagnosis is achieved. A few useful references will be cited and a table will be provided for differential diagnosis in some cases. The major emphasis is the provision of 500 color photos of peripheral blood smears, bone marrow aspirates, core biopsy, lymph node biopsy and biopsies of other solid organs that are involved with lymphomas and leukemias. Pictures of other diagnostic parameters, such as flow cytometric histograms, immunohistochemical stains, cytogenetic karyotypes, fluorescence in situ hybridization and polymerase chain reaction, will also be included.A comprehensive approach with consideration of clinical, morphologic, immunophenotypic and molecular genetic aspects is the best way to achieve a correct diagnosis. After reading this book, the reader will learn to make a diagnosis not only based on the morphology alone but also in conjunction with other parameters.
Preface 4
Acknowledgments 6
Contents 7
Part I 10
Introduction 11
Classification of Lymphoma and Leukemia 11
Morphology of Hematopoietic Cells 16
Comparison Between Flow Cytometry and Immunohistochemistry 30
Monoclonal Antibodies Used for Immunophenotyping 30
Cytogenetic Techniques for Hematologic Neoplasms 32
Molecular Biology Techniques for Hematologic Neoplasms 34
Diagnostic Procedures for Hematologic Neoplasms 35
References 38
Part II 40
Hematologic Neoplasms 41
Case 1 41
References 46
Case 2 47
References 50
Case 3 51
References 55
Case 4 56
References 62
Case 5 63
References 67
Case 6 68
References 73
Case 7 74
References 78
Case 8 79
References 85
Case 9 86
References 90
Case 10 91
References 96
Case 11 97
References 101
Case 12 102
References 105
Case 13 107
References 112
Case 14 113
References 117
Case 15 118
References 121
Case 16 122
References 125
Case 17 126
References 130
Case 18 131
References 134
Case 19 135
References 140
Case 20 141
References 146
Case 21 147
References 151
Case 22 152
References 157
Case 23 158
References 162
Case 24 163
References 166
Case 25 167
References 171
Case 26 172
References 177
Case 27 178
References 183
Case 28 184
References 189
Case 29 190
References 193
Case 30 194
References 199
Case 31 200
References 205
Case 32 206
References 209
Case 33 210
References 216
Case 34 217
References 223
Case 35 224
References 229
Case 36 230
References 233
Case 37 234
References 239
Case 38 240
References 246
Case 39 247
References 251
Case 40 252
References 257
Case 41 258
References 264
Case 42 265
References 272
Case 43 273
References 278
Case 44 279
References 284
Case 45 285
References 291
Case 46 292
References 295
Case 47 296
References 301
Case 48 302
References 306
Case 49 307
References 312
Case 50 313
References 319
Case 51 320
References 324
Case 52 325
References 328
Case 53 329
References 337
Case 54 338
References 344
Case 55 345
References 349
Case 56 350
References 353
Case 57 355
References 359
Case 58 360
References 366
Case 59 367
References 371
Case 60 372
References 375
Case 61 376
References 379
Case 62 381
References 386
Case 63 387
References 390
Case 64 391
References 398
Case 65 399
References 402
Case 66 403
References 407
Case 67 408
References 412
Case 68 413
References 420
Case 69 421
References 428
Case 70 429
References 435
Case 71 436
References 439
Case 72 440
References 444
Case 73 445
References 448
Case 74 449
References 456
Case 75 457
References 463
Case 76 464
References 470
DiseasesMimicking Hematologic Neoplasms 471
Case 77 472
References 476
Case 78 477
References 480
Case 79 481
References 485
Case 80 486
References 493
Case 81 494
References 498
Case 82 499
References 502
Case 83 503
References 506
Case 84 507
References 512
Case 85 513
References 518
Index 520
| Erscheint lt. Verlag | 12.6.2009 |
|---|---|
| Zusatzinfo | XI, 525 p. |
| Verlagsort | New York |
| Sprache | englisch |
| Themenwelt | Medizinische Fachgebiete ► Innere Medizin ► Hämatologie |
| Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie | |
| Studium ► 1. Studienabschnitt (Vorklinik) ► Biochemie / Molekularbiologie | |
| Studium ► 2. Studienabschnitt (Klinik) ► Pathologie | |
| Schlagworte | biopsy • Blood • Bone marrow • Cell • classification • cytogenetics • Differential Diagnosis • Genetics • Hematology • leukemia • Lymphoma • Molecular Biology • molecular genetics • Pathology • Tumor |
| ISBN-10 | 0-387-89848-4 / 0387898484 |
| ISBN-13 | 978-0-387-89848-3 / 9780387898483 |
| Haben Sie eine Frage zum Produkt? |
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