Dermatopathology: The Basics (eBook)

Kim M. Hiatt, Bruce R. Smoller (Autoren)

eBook Download: PDF

2009 | 2009
XII, 156 Seiten
Springer US (Verlag)
978-1-4419-0024-1 (ISBN)

Infos

Dermatopathology: The Basics serves as an effective and efficient handbook for the student of dermatopathology, and as a practical bench reference for the practicing diagnostician who desires rapid access to criteria that are useful in differentiating histologically similar entities. The reader is able to focus upon a single histologic observation, i.e., inflammatory conditions without epidermal changes, and use this as a starting point from which to build a differential diagnosis based upon pattern recognition. As each entity is addressed, there is a concise discussion of the basic clinical findings and epidemiologic associations. This is followed by a histologic description, highlighting areas that serve to discriminate between the entity under discussion and similar ones. Any immunologic studies that might augment the diagnostic sensitivity or specificity are discussed.

Chapters are thematically based and consist of essential bullet points arranged in organized outlines allowing for easy access and direct comparison between entities. The salient histologic features are depicted with abundant high quality, full-color photomicrographs placed immediately adjacent to the appropriate histologic bullet points. This volume serves as an effective and efficient handbook for the student of dermatopathology, and as a practical bench reference for the practicing diagnostician who desires rapid access to criteria that are useful in differentiating histologically similar entities. The elaborate pictorial documentation serves as an atlas of the commonest dermatologic disorders.

 

Inhalt

Preface 5
Acknowledgements 7
Contents 8
1 Normal Cutaneous Histology 12
Basic Skin Anatomy 12
Epidermis 12
Keratinocytes 12
Stratum Corneum 13
Stratum Granulosum 14
Stratum Spinosum 14
Stratum Basalis 15
Melanocytes 16
Langerhans Cells 17
Merkel Cells 19
Epidermal Appendages 19
Hair Follicles 19
Hair Follicle Anatomy (Anagen Phase) 20
Sebaceous Glands 23
Eccrine Glands 24
Eccrine Ducts 25
Apocrine Glands 27
Basement Membrane Zone 27
Basal Keratinocyte 29
Lamina Lucida 29
Lamina Densa 30
Sub lamina Densa 30
Dermis 30
Vasculature 31
Collagens 33
Elastic Tissue 34
Nerves 35
Muscles 37
Dermal Dendrocytes 38
Lymphocytes 39
Mast Cells 39
Fibroblasts 40
Subcutaneous Fat 40
Skin of Special Sites 41
2 How to Maximize Information from a Skin Biopsy 47
Presumed Neoplastic Processes 48
What is the Differential Diagnosis? 48
Are the Margins Important? 49
Melanocytic Neoplasms 50
Keratinocytic Neoplasms 51
Adnexal Neoplasms 53
Dermal Neoplasms 56
Hematopoietic Neoplasms 59
Inflammatory Processes 60
Blistering Diseases 60
''Dermatitis'' and ''Rash'' 62
Infectious diseases 63
Connective Tissue Diseases 66
Direct Immunofluorescence 67
Vasculitis 67
Panniculitis 68
Alopecia 69
Miscellaneous Conditions 70
Presumed Connective Tissue Nevus, Anetoderma, Epidermal Nevus 70
Rules of Thumb 70
3 Special Stains in Dermatopathology 72
Histochemical Stains 72
Commonly Used Special Stains 72
Periodic Acid-Schiff (PAS) 72
PAS Uses 73
Alcian Blue 73
Alcian Blue/Colloidal Iron Uses 74
Elastic von Gieson 74
Von Gieson Uses 74
Brown and Brenn Stain 75
Acid Fast Stain (AFB) 75
Fite Stain 76
Giemsa 76
Giemsa Uses 76
Warthin-Starry 77
Massons Trichrome 77
Congo Red 78
Fontana Stain for Melanin 80
Chloroacetate Esterase 80
Perls 81
4 Immunopathology in Diagnostic*5ptDermatopathology 83
Tool Box: Antibody Panel 83
What Is a Tool Box? 83
Epithelial Markers 83
Mesenchymal Markers 86
Neuroectodermal Markers 87
Hematopoietic Markers 89
Miscellaneous Markers 91
Requirements for Interpretation 93
Pitfalls in Interpretation 93
Strategy for Immunopathology 94
Immunopathology 96
5 Differential Diagnosis of Normal Skin 100
Tinea Versicolor 101
Ichthyoses 103
Ichthyosis (X-Linked) 103
Ichthyosis (Lamellar) 104
Erythrasma 104
Ichthyosis Vulgaris 107
Pemphigus Foliaceus/Erythematosus 108
Vitiligo 109
Caf-Au-Lait Macule 111
Nevus Depigmentosus (Nevus Achromicus) 111
Connective Tissue Nevus 113
Cutis Laxa 115
Morphea 117
Anetoderma (Macular Atrophy, Focal Dermal Elastolysis) 120
Wrinkling due to Mid-dermal Elastolysis 121
Dermal Deposition Disorders 121
Amyloidosis 122
Localized Cutaneous Amyloidosis 122
Pretibial Myxedema 124
Sclerodema 126
Scleromyxedema 128
Nephrogenic Systemic Fibrosis 128
Conditions with Minimal Inflammation 131
Small Plaque (Guttate) Parapsoriasis (Digitate Dermatosis) 131
Urticaria 133
Urticaria Pigmentosa 133
Further Reading 1
Index 1

Produkt-Details

• Erscheint lt. Verlag: 10.6.2009
• Zusatzinfo: XII, 156 p. 190 illus., 155 illus. in color.
• Verlagsort: New York
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Dermatologie
• Themenwelt: Studium ► 2. Studienabschnitt (Klinik) ► Pathologie
• Schlagworte: biopsy • Differential Diagnosis • epidermal changes • histologic features • Histology • inflammation • Skin • skin disorders
• ISBN-10: 1-4419-0024-1 / 1441900241
• ISBN-13: 978-1-4419-0024-1 / 9781441900241