Neuroimmunology of the Skin (eBook)

Basic Science to Clinical Practice

Richard D. Granstein, Thomas A. Luger (Herausgeber)

eBook Download: PDF

2009 | 2009
XI, 251 Seiten
Springer Berlin (Verlag)
978-3-540-35989-0 (ISBN)

Infos

Much anecdotal information has suggested an influence of psychology and the nervous system on immunity within the skin and the expression of inflammatory skin disorders. Recent years have seen an explosion of knowledge providing a scientific basis for important regulatory interactions between the nervous system, the endocrine system and the immune system within the skin. The results of recent investigations have important implications, not only for an understanding of cutaneous immunity, but also for the development of novel treatments for diseases involving abnormal inflammation or immune reactivity within the skin. This book provides a comprehensive and interdisciplinary review of the molecular biology, cell biology, biochemistry and clinical aspects of nervous system-immune system interactions within the skin. It includes contributions from leading world experts in these areas. The contents are relevant to both investigators and clinicians interested in the skin, its functions and its disorders.

Inhalt

Editors 3
Preface 5
Contents 6
List of Contributors 8
Section I Basic Neuroimmunology of the Skin 11
Neuroanatomy of the Skin 12
Neuroreceptors and Mediators 22
Autonomic Effects on the Skin 32
Immune Circuits of the Skin 42
Modulation of Immune Cells 54
by Products of Nerves 54
Regulation of Immune Cells 63
by POMC Peptides 63
Regulation of Cutaneous 72
Immunity by Catecholamines 72
The Role of Neuropeptide 82
Endopeptidases in Cutaneous Immunity 82
Neuroinflammation 95
and Toll-Like Receptors in the Skin 95
Section II Stress and Cutaneous Immunity 109
Neuroendocrine Regulation 110
of Skin Immune Response 110
Effects of Psychological Stress 118
on Skin Immune Function: Implications for Immunoprotection Versus Immunopathology 118
Photoneuroimmunology: 129
Modulation of the Neuroimmune System by UV Radiation 129
Section III Neurobiology of Skin Appendages 141
Neurobiology of Hair 142
Neurobiology 161
of Sebaceous Glands 161
Neurobiology of Skin 169
Appendages: Eccrine, Apocrine, and Apoeccrine Sweat Glands 169
Section IV The Nervous System and the Pathophysiology of Skin Disorders 178
Neurophysiology of Itch 179
Neuroimmunologic Cascades 187
in the Pathogenesis of Psoriasis and Psoriatic Arthritis 187
Neuroimmunology 197
of Atopic Dermatitis 197
Stress and Urticaria 208
Acne Vulgaris and Rosacea 217
Wound Healing and Stress 231
Index 246

Produkt-Details

• Erscheint lt. Verlag: 8.2.2009
• Zusatzinfo: XI, 251 p.
• Verlagsort: Berlin
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Dermatologie
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Neurologie
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Psychiatrie / Psychotherapie
• Themenwelt: Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
• Schlagworte: anatomy • biochemistry • Catecholamines • Cell Biology • immune system • immunity • inflammation • Molecular Biology • nervous system • Neurobiology • Neuroendocrine Effects of Stress • Neurophysiology • pathophysiology • Photoneuroimmunology • Physiology • Psoriasis • Psychology • Skin • Stress
• ISBN-10: 3-540-35989-3 / 3540359893
• ISBN-13: 978-3-540-35989-0 / 9783540359890