Molecular Imaging II (eBook)

Wolfhard Semmler, Markus Schwaiger (Herausgeber)

eBook Download: PDF

2008 | 2008
XXVII, 365 Seiten
Springer Berlin (Verlag)
978-3-540-77496-9 (ISBN)

Infos

The aim of this textbook of molecular imaging is to provide an up to date review of this rapidly growing field and to discuss basic methodological aspects necessary for the interpretation of experimental and clinical results. Emphasis is placed on the interplay of imaging technology and probe development, since the physical properties of the imaging approach need to be closely linked with the biologic application of the probe (i.e. nanoparticles and microbubbles). Various chemical strategies are discussed and related to the biologic applications. Reporter-gene imaging is beeing addressed not only in experimental protocols, but also first clinical applications are discussed. Finally, strategies of imaging to characterize apoptosis and angiogenesis are described and discussed in the context of possible clinical translation.

Inhalt

Foreword 5
Preface 7
Contents 10
Contents of Companion Volume 185/I 12
Contributors 14
Glossary 18
Amplification Strategies 27
Optical Methods 28
PET and SPECT 38
Environment-sensitive and Enzyme-sensitive MR Contrast Agents 61
Molecular Targets and Biomarkers for Imaging 82
Peptides, Multimers and Polymers 83
Small Molecule Receptors as Imaging Targets 115
Enzymes/Transporters 152
Phage Peptide Display 165
Applications: Experimental Imaging 184
Molecular Imaging: Reporter Gene Imaging 185
The Use of Ultrasound in Transfection and Transgene Expression 242
Magnetic Resonance of Mouse Models of Cardiac Disease 261
Translational Imaging: Imaging of Apoptosis 274
Molecular Imaging of PET Reporter Gene Expression 291
Noninvasive Cell Tracking 318
Noninvasive Tracer Techniques to Characterize Angiogenesis 335
Molecular Imaging-guided Gene Therapy of Gliomas 352
Index 371

Produkt-Details

• Erscheint lt. Verlag: 15.7.2008
• Reihe/Serie: Handbook of Experimental Pharmacology
• Reihe/Serie: Handbook of Experimental Pharmacology
• Zusatzinfo: XXVII, 365 p. 96 illus., 44 illus. in color.
• Verlagsort: Berlin
• Sprache: englisch
• Themenwelt: Medizinische Fachgebiete ► Radiologie / Bildgebende Verfahren ► Radiologie
• Themenwelt: Medizin / Pharmazie ► Pharmazie
• Themenwelt: Studium ► 1. Studienabschnitt (Vorklinik) ► Biochemie / Molekularbiologie
• Schlagworte: Cell • gene therapy • Imaging • Magnetic Resonance • Molecular Imaging • positron emission tomography (PET) • Radiaton Oncology • Research • SPECT • ultrasonography • Ultrasound
• ISBN-10: 3-540-77496-3 / 3540774963
• ISBN-13: 978-3-540-77496-9 / 9783540774969