Gene Therapy for Cancer (eBook)

Kelly K. Hunt, Stephan A. Vorburger, Stephen G. Swisher (Herausgeber)

eBook Download: PDF

2007 | 2007
XII, 469 Seiten
Humana Press (Verlag)
978-1-59745-222-9 (ISBN)

Infos

The three sections of this volume present currently available cancer gene therapy techniques. Part I describes the various aspects of gene delivery. In Part II, the contributors discuss strategies and targets for the treatment of cancer. Finally, in Part III, experts discuss the difficulties inherent in bringing gene therapy treatment for cancer to the clinic. This book will prove valuable as the volume of preclinical and clinical data continues to increase.

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The possibility of treating cancer, a disease defined by genetic defects, by introducing genes targeting these very alterations has led to an immense interest in gene therapy for cancer. Although incremental successes have been realized, enthusiasm for gene therapy has declined due to an increasing number of obstacles. These obstacles include vector systems that do not reach systemic metastases, therapeutic genes with redundant mec- nisms allowing for cellular resistance, and toxicities in clinical trials leading to premature closure of these studies. Different tactics to overcome or circumvent these obstacles have catalyzed the development of a wide range of gene therapy approaches. Thus far, almost two-thirds of gene therapy trials have focused on cancer. This reflects the concept that gene therapy approaches for the treatment of cancer do not necessarily require long-term expression of the gene as is necessary for the treatment of primary genetic defects like hemophilia or juvenile diabetes. Unlike the treatment of genetic defects, where expr- sion of the corrected gene needs to be strong, permanent and, sometimes regulated, tactics to treat tumors can be based on temporary and locally limited effects. In addition, cancer cells have different properties than normal cells and this allows for targeting gene therapy to specific cells, a major advantage over current antitumor therapies, which are also toxic to normal cells and tissues.

Inhalt

PREFACE 6
CONTENTS 8
CONTRIBUTORS 10
I VECTORS 13
Adenovector-Mediated Cancer Gene Therapy 14
Efficacy, Toxicity, and Immunogenicity of Adenoviral Vectors 34
Lentiviral and Retroviral Vector Systems 50
Vaccinia and Pox-Virus 83
Herpes Simplex Virus as a Therapy for Cancer 96
Alphavirus Vectors for Gene Therapy Applications 118
Vesicular Stomatitis Virus and RNA Viruses as Gene Therapy Vectors 129
Parvovirus Vectors 149
Nonviral Vector Systems 164
II GENE THERAPY APPROACHES 178
Oncogenes, Tumor Suppressor Genes and Apoptosis- Inducing Genes Utilized in Cancer Gene Therapy 179
Gene Silencing Therapy Against Cancer 191
Tumor Targeting–Retargeted Adenovirus 203
Oncolytic Herpes Simplex for Gene Therapy in Preclinical and Clinical Trials 219
Cytokine Gene Therapy for Genitourinary Cancer 229
Combination of Gene Therapy with Radiation 248
Gene Transfer for Chemoprotection and Enrichment of Hematopoietic Stem Cells 262
Nonviral Genetic Vaccines for Cancer 285
Gene Therapy Targeted at Angiogenesis and Lymphangiogenesis for Cancer Treatment 305
Tumor-Specific Replicating Adenoviruses 335
III CLINICAL APPLICATIONS 353
Problems, Side Effects, and Disappointments in Clinical Cancer Gene Therapy 354
Trials and Tribulations in Developing Clinical Trials of Gene Therapy 389
Phase I Clinical Experience with Intravenous Administration of PV701, an Oncolytic Virus 401
MDA-7/IL-24 as a Multi-Modality Therapy for Cancer 414
Development of Therapeutic Genes for Breast Cancer Treatment 435
Steps in a Translational Cancer Gene Therapy Trial 447
Index 461

Produkt-Details

• Erscheint lt. Verlag: 26.10.2007
• Reihe/Serie: Cancer Drug Discovery and Development
• Reihe/Serie: Cancer Drug Discovery and Development
• Zusatzinfo: XII, 469 p. 85 illus., 16 illus. in color.
• Verlagsort: Totowa
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Biomedizin
• Themenwelt: Medizinische Fachgebiete ► Innere Medizin ► Hämatologie
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
• Schlagworte: angiogenesis • Apoptosis • Cancer Treatment • clinical trial • gene therapy • gene transfer • hematopoietic stem cell • immune system • Metastasis • ovarian cancer • Stem Cells • Tumor
• ISBN-10: 1-59745-222-X / 159745222X
• ISBN-13: 978-1-59745-222-9 / 9781597452229