Regional Cancer Therapy (eBook)

Peter M. Schlag, Ulrike S. Stein (Herausgeber)

eBook Download: PDF

2007 | 2007
XIV, 455 Seiten
Humana Press (Verlag)
978-1-59745-225-0 (ISBN)

Infos

This volume provides a biological and pharmacological background for regional cancer therapy, strategies and techniques for regional therapies, and specific indications and results for different tumor entities. Clinical trial concepts and detailed treatment protocols are also presented. This book is essential reading for researchers and clinicians engaged in seeking advanced therapeutic options for cancer patients worldwide.

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Regional cancer therapies remain important options in the management of malignant disease, in spite of the venue of more targeted agents for systemic therapies. New te- nologies and better guidance systems for radiofrequency ablation and intrastitial laser therapies, highly selective intravascular approaches with improved catheters and gu- ance systems, improved agents for embolizations, and new vasoactive drugs for isolated limb and liver perfusions are just a few of the new developments in a field that is alive and progressing. Regional Cancer Therapy, so well put together by the editors Peter M. Schlag and Ulrike S. Stein, presents an overview of today's realities and tomorrow's possibilities. Regional cancer therapy models provide ways to make new discoveries about tumor biology and new agents that may be used regionally as well as systemically. This book should therefore be of interest to all clinicians and scientists with an interest in tumor biology as well as clinical advances. Alexander M. M. Eggermont, MD, PhD Professor and Head of Surgical Oncology Erasmus University MC-Daniel den Hoed Cancer Center Rotterdam, the Netherlands v PREFACE The treatment of malignant tumors has been substantially improved in recent years due to developments in clinical medicine and technology as well as by advances in mole- lar biological research. Modern molecular and genetic techniques allow the charact- ization of molecules that are decisive for tumor development and progression.

Inhalt

FOREWORD 6
PREFACE 7
CONTENTS 8
I BACKGROUND 14
Biological Background 15
Pharmacological Background 31
Isolated Limb and Organ Perfusion Laboratory Models 41
II TECHNIQUES AND PREREQUISITES FOR REGIONAL THERAPY 57
Interventional Radiotherapy 58
Surgical Strategies 70
Regional Thermotherapy 84
Radiofrequency Thermal Ablation 102
Cryoablation for Primary and Secondary Liver Tumors 112
A Personal History of Photodynamic Therapy 127
Ultrasound- Guided Therapy 143
Nanocarriers and Drug Delivery 173
Local Gene Therapy for Cancer 190
III INDICATIONS AND RESULTS FOR DIFFERENT TUMOR ENTITIES 206
Regional Chemotherapy of Primary and Metastatic Liver Tumors 207
Focal Liver Ablation Techniques in Primary and Secondary Liver Tumors 237
Regional Therapy for Peritoneal Surface Malignancy 276
Malignant Peritoneal Mesothelioma 290
Regional Therapy of Pancreatic Cancer 310
Regional Breast Cancer Treatment 320
Regional Therapy in Ovarian Cancer 336
Regional Therapy of Bladder Tumors 349
Regional Therapy of Rectal Cancer 360
Percutaneous Laser Ablation of Lung Metastases 371
Regional Therapy of Brain Tumors 382
Hyperthermic Intrapleural Chemotherapy in Pleural Malignancy 397
Isolated Limb Perfusion in Advanced Soft Tissue Sarcomas 408
Isolated Limb Perfusion for Melanoma In Transit Metastases 417
Outpatient Brachytherapy with Seeds 427
Index 445

Produkt-Details

• Erscheint lt. Verlag: 20.10.2007
• Reihe/Serie: Cancer Drug Discovery and Development
• Reihe/Serie: Cancer Drug Discovery and Development
• Vorwort: M.M. Eggermont
• Zusatzinfo: XIV, 455 p.
• Verlagsort: Totowa
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Chirurgie
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
• Themenwelt: Medizinische Fachgebiete ► Radiologie / Bildgebende Verfahren ► Radiologie
• Themenwelt: Medizin / Pharmazie ► Studium
• Schlagworte: gene therapy • Laboratory • Liver tumor • Positron Emission Tomography • Radiaton Oncology • surgical oncology • Tumor • Ultrasound
• ISBN-10: 1-59745-225-4 / 1597452254
• ISBN-13: 978-1-59745-225-0 / 9781597452250