Liver Immunology (eBook)

Principles and Practice

M. Eric Gershwin, Michael P. Manns, John M. Vierling (Herausgeber)

eBook Download: PDF

2008 | 2007
XV, 486 Seiten
Humana Press (Verlag)
978-1-59745-518-3 (ISBN)

Infos

Immunology is a broad branch of biomedical science that covers the study of all aspects of the immune system in all organisms. This volume is a must-read for novice and expert alike. In an easy-to-read and thorough format, it covers bacterial, parasitic and viral infections of the liver, autoimmune liver disease, alcoholic and nonalcoholic fatty liver diseases, and transplantation.

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Immunology is a broad branch of biomedical science that covers the study of all aspects of the immune system in all organisms. It deals with, among other things, the physiological functioning of the immune system in states of both health and disease; malfunctions of the immune system in immunological disorders (autoimmune diseases, hypersensitivities, immune deficiency, allograft rejection); the physical, chemical and physiological characteristics of the components of the immune system in vitro, in situ, and in vivo. Immunology has various applications in several disciplines of science, and as such is further divided.Liver Immunology: Principles and Practice covers bacterial, parasitic and viral infections of the liver, autoimmune liver disease, alcoholic and nonalcoholic fatty liver diseases, and transplantation in an easy-to-read and thorough format. Authors also address the key issues that have arisen in this field in recent years, including physiological roles of hepatocytes, sinusoidal lining cells, activated macrophages (Kupffer cells), cholangiocytes and stellate cells, and their modulation of T cells, natural killer (NK) cells and NKT cells. This volume will become a must-read for clinicians, investigators and students, novice and expert alike.

Inhalt

Preface 6
Contents 7
Contributors 10
Contemporary Liver Immunology and Immunopathology 13
A Short Primer on Fundamental Immunology 25
Role and Function of Liver Sinusoidal Endothelial Cells 35
Innate Immune Mechanisms in the Liver 50
Antigen Processing and Presentation in the Liver 58
Adaptive Immunity in the Liver 69
Hepatic NK, NKT, and T Cells 79
Cytokines in Liver Health and Disease 91
Prevalence and Significance of Autoantibodies in Acute and Chronic Liver Diseases and Hepatocellular Carcinoma 102
The Role of Inflammation and Immunity in the Pathogenesis of Liver Fibrosis 118
Clinical Use of Immunopathology Techniques in Liver Diseases 129
Tumor Immunology 143
Innate and Adaptive Immune Responses to Bacterial and Parasite Infections 157
Immune Response to Hepatitis A and E Viruses 167
Role of the Immune Response in Hepatitis B 182
Immune Responses in Acute and Chronic Hepatitis C 195
Immunopathogenesis of Extrahepatic Manifestations in HAV, HBV, and HCV Infections 211
Immunogenetics of Autoimmune Liver Disease 221
Primary Biliary Cirrhosis and Autoimmune Cholangitis 234
Sclerosing Cholangitis 247
Autoimmune Hepatitis 260
Unique Aspects of Autoimmune Hepatitis in Children 273
Overlap Syndromes of Autoimmune Hepatitis With Primary Biliary Cirrhosis and Primary Sclerosing Cholangitis 280
Animal Models of Autoimmune Liver Diseases 287
The Immune Response in the Pathogenesis 302
of Alcoholic Liver 302
Immunomodulation Therapy for Alcoholic Hepatitis 315
Role of Immune Response in Nonalcoholic Fatty Liver Disease 329
Mechanisms of Acute Liver Failure 339
Immune Mechanisms in Drug-Induced Hepatotoxicity 351
Acute and Chronic Liver Diseases Induced by Drugs or Xenobiotics 363
Clinical Use of Immunosuppressive Drugs to Control the Immune Response 378
Hepatic Complications of Hematopoietic Cell Transplantation 395
Acute and Chronic Rejection of the Liver Allograft 408
Immunological Tolerance in Allo- and Xenografts 417
Autoimmune Diseases in Transplanted Livers 434
Immunopathogenesis and Outcomes of Recurrent Hepatitis C 441
Index 453

Produkt-Details

• Erscheint lt. Verlag: 24.1.2008
• Zusatzinfo: XV, 486 p.
• Verlagsort: Totowa
• Sprache: englisch
• Themenwelt: Medizinische Fachgebiete ► Innere Medizin ► Hepatologie
• Themenwelt: Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
• Schlagworte: Antigen • autoimmune disease • Bacteria • Cytokine • Diseases • Genetics • Hepatitis • hepatology • immunology • Infection • Infections • Liver • liver disease • parasite • Pathology • Transplantation
• ISBN-10: 1-59745-518-0 / 1597455180
• ISBN-13: 978-1-59745-518-3 / 9781597455183