Antiangiogenic Agents in Cancer Therapy (eBook)

Beverly A. Teicher, Lee M. Ellis (Herausgeber)

eBook Download: PDF

2008 | 2nd ed. 2008
XVIII, 559 Seiten
Humana Press (Verlag)
978-1-59745-184-0 (ISBN)

Infos

This volume represents a compendium of scientific findings and approaches to the study of angiogenesis in cancer. The second edition of Antiangiogenic Agents in Cancer Therapy is intended to give a current perspective on the state-of-the-art of angiogenensis and therapy directed at this process.

Antiangiogenesis is a dynamic and evolving field in oncology. New therapeutic targets continue to emerge followed by the rapid development of new therapeutic agents to be investigated in clinical trials. Optimizing the therapeutic potential of antiangiogenic agents in combination with the other therapies in the armamentarium to fight cancer will be an on-going challenge.

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Antiangiogenesis remains a dynamic and evolving field in oncology. New therapeutic targets continue to emerge followed by the rapid development of new therapeutic agents to be investigated in clinical trials. Optimizing the therapeutic potential of antiangiogenic agents in combination with the other therapies in the armamentarium to fight cancer will be an on-going challenge. Antiangiogenic Agents in Cancer Therapy, Second Edition provides a current, up-dated perspective on the state of the art of angiogenesis and therapy with a compendium of scientific findings and approaches to the study of angiogenesis in cancer.  Leaders in the field present chapters on such topics as the environmental influences and the genetic and physiologic abnormalities that mediate angiogenesis and its role in the progression of malignant disease, working models of tumor angiogenesis, and the role of angiogenesis inhibition in the therapy of malignant disease in humans. Comprehensive and cutting-edge, Antiangiogenic Agents in Cancer Therapy, Second Edition is an ideal, valuable guide to the most recent advances in the field, and a collection that will be useful for many years to come.

Inhalt

Preface 6
Contents 7
Contributors 10
I Basic Biology of Angiogenesis 18
Vascular Endothelial Growth Factor Family and Its Receptors 19
The Cycle Between Angiogenesis, Perfusion, and Hypoxia in Tumors 43
The Role of Integrins in Tumor Angiogenesis 64
Tumor Endothelial Cell Abnormalities 87
The Extracellular Matrix and VEGF Processing 99
Endothelial Precursor Cells 112
Role of Pericytes in Angiogenesis 129
Newer Vascular Targets 145
Chemokines in Angiogenesis 166
Angiopoietin/Tie2 Signaling Regulates Tumor Angiogenesis 182
Imaging Angiogenesis 199
Tumor Blood Vessels 214
Lymphatic System in the Pathology of Cancer 234
II Translational Research in Tumor Angiogenesis 251
VEGF in the Adult 252
Normalization of Tumor Vasculature and Microenvironment 267
Metronomic Low-Dose Antiangiogenic Chemotherapy in Mice and Man 283
Small-Molecule Vascular Disrupting Agents in Cancer Therapy 303
Normalization of Tumor Vasculature and Improvement of Radiation Response by Antiangiogenic Agents 317
Challenges in Translating Antiangiogenic Therapy from the Bench to Bedside 328
Regulation of Angiogenesis in Cancer and Its Therapeutic Implications 336
III Antiangiogenic Therapy in the Clinical Trial Results and Future Directions 355
Angiogenesis and Angiogenesis Inhibition in Sarcomas 356
Antiangiogenesis Agents in Colorectal Cancer 373
Antiangiogenic Therapy for Primary CNS Tumors 413
Angiogenesis Inhibitors for the Treatment of Lung Cancer 437
Antiangiogenic Therapy of Renal Cell Carcinoma 455
Antiangiogenesis Therapies in Gynecologic Malignancies 468
Antiangiogenic Agents in Myeloid Malignancies 484
Angiogenesis in Malignant and Non- Malignant Pediatric Tumors 501
Prognostic and Predictive Significance of Surrogate Biomarkers of Angiogenesis 513
Endpoints for the Determination of Efficacy of Antiangiogenic Agents in Clinical Trials 535
The Role of Imaging in the Clinical Development of Antiangiogenic Agents 551
Index 563

Produkt-Details

• Erscheint lt. Verlag: 8.1.2008
• Reihe/Serie: Cancer Drug Discovery and Development
• Reihe/Serie: Cancer Drug Discovery and Development
• Zusatzinfo: XVIII, 559 p.
• Verlagsort: Totowa
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Chirurgie
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
• Themenwelt: Studium ► 2. Studienabschnitt (Klinik) ► Pathologie
• Schlagworte: angiogenesis • Cancer • Cancer Therapy • carcinoma • Cell • Chemokine • Chemotherapy • clinical trial • CNS • Imaging • Oncology • Pathology • radiotherapy • Research • surgical oncology • Tumor
• ISBN-10: 1-59745-184-3 / 1597451843
• ISBN-13: 978-1-59745-184-0 / 9781597451840